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The product of DSTN belongs to the actin-binding proteins ADF family. Additionally we are shipping Destrin Antibodies (78) and Destrin Kits (10) and many more products for this protein.
Showing 10 out of 11 products:
Human Destrin Protein expressed in Escherichia coli (E. coli) - ABIN1098314
Kanamori, Hayakawa, Suzuki, Titani: Identification of two 17-kDa rat parotid gland phosphoproteins, subjects for dephosphorylation upon beta-adrenergic stimulation, as destrin- and cofilin-like proteins. in The Journal of biological chemistry 1995
Show all 2 references for ABIN1098314
Dstncorn1 mice are homozygous for a spontaneous null actin depolymerizing factor destrin (DSTN) allele, which results in an increase in serum response factor (Srf) expression.This study performs identification of functional pathways associated with the conditional ablation of serum response factor in Dstn corn1 mice.
Actin depolymerizing factor/cofilin (show CFL1 Proteins) double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
SRF binding is significantly decreased in the destrin (corn1) mutant cornea.
A single QTL is responsible for modification of neovascularization in the Dstn null mutation mouse.
findings identify actin-depolymerizing factor (ADF) as a key signaling molecule in the regulation of BBB integrity and suggest that ADF (show TXN Proteins) might be used as a target to modulate diseases accompanied by ox-LDL-induced BBB compromise.
n-cofilin can compensate for the loss of ADF in excitatory synapses. ADF and n-cofilin cooperate in controlling synaptic actin content
Results indicate that ADF (show TXN Proteins) activity, provided by either cofilin1 or destrin, is essential in UB epithelial cells for normal growth and branching.
Findings show that ADF (show TXN Proteins)/n-cofilin (show CFL1 Proteins)-null MKs (show MKKS Proteins) develop significantly fewer proplatelets.
Developmentally regulated actin filament depolymerizing factor expression in the cochlea suggests a temporally restricted function in the stereocilia and a hitherto undescribed role of ADF (show TXN Proteins).
Destrin deletion has differential effects on spontaneous hem- and lymphangiogenesis in the normally avascular cornea.
analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover
Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness
The ADF (show GSN Proteins)/cofilin1-dependent severing of actin filaments exposes and promotes the activation of SPCA1 (show ATP2C1 Proteins), which pumps Ca(2 (show CA2 Proteins)+) into the lumen of the TGN (show TG Proteins) for the sorting of the class of secretory cargo that binds Ca(2 (show CA2 Proteins)+).
Changes in the expression of cytoskeletal regulatory proteins such as LIMK (show LIMK1 Proteins) and cofilin (show CFL1 Proteins) may play a role in weakening thoracic aortic medial tissue, as a precondition to thoracic aortic dissection.
The results of this study suggested that temporally regulated ADF/cofilin (show CFL1 Proteins) activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity.
differences in actin binding by human ADF (show GSN Proteins) and cofilin (show CFL1 Proteins)
Important sequence differences between actin-depolymerizing factor/cofilin (show CFL1 Proteins) were correlated with unique structural determinants in the F-actin-binding site to account for differences in biochemical activities of the two proteins.
In the absence of any crystal structures of ADF or cofilin in complex with actin, these studies provide further information about the binding sites on F-actin for these important actin regulatory proteins.
destrin is a significant regulator of various processes important for invasive phenotype of human colon cancer Isreco1 cells whereas cofilin-1 (show CFL1 Proteins) may be involved in only a subset of them
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.
, destrin (actin depolymerizing factor)
, putative destrin
, actin-depolymerizing factor
, corneal disease 1
, sid 23
, bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))
, actin depolymerizing factor