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Probably involved in mitochondrial protein import. Additionally we are shipping DnaJ (Hsp40) Homolog, Subfamily B, Member 1 Kits (44) and DnaJ (Hsp40) Homolog, Subfamily B, Member 1 Proteins (19) and many more products for this protein.
Showing 10 out of 324 products:
Human Polyclonal DNAJB1 Primary Antibody for IHC (p), WB - ABIN1882092
Ohtsuka, Hata: Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. in Cell stress & chaperones 2001
Show all 4 Pubmed References
Human Monoclonal DNAJB1 Primary Antibody for FACS, IF - ABIN2454060
Ramdzan, Polling, Chia, Ng, Ormsby, Croft, Purcell, Bogoyevitch, Ng, Gleeson, Hatters: Tracking protein aggregation and mislocalization in cells with flow cytometry. in Nature methods 2012
Human Polyclonal DNAJB1 Primary Antibody for ICC, IF - ABIN361670
Hattori, Liu, Tohnai, Ueda, Kaneda, Kobayashi, Tanabe, Ohtsuka: Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells. in Cell structure and function 1992
Show all 8 Pubmed References
These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins.
DNAJB1-PRKACA (show PRKACA Antibodies) was evaluated as a key driver of fibrolamellar carcinoma and as a candidate therapeutic target
siRNA experiments confirmed that a reduction in Hsp27 (show HSPB1 Antibodies) or Hsp40 rescued CFTR (show CFTR Antibodies) in the DeltaF508 mutant, but the rescue was not additive or synergistic with C4 + 18 treatment, indicating these correctors shared a common pathway for rescue
study provides a new molecular mechanism to regulate EGFR (show EGFR Antibodies) signaling through modulation of MIG6 (show ERRFI1 Antibodies) by DNAJB1 as a negative regulator.
Whole exome sequencing followed by immunohistochemistry of fibrolamellar hepatocellular carcinoma cell lines and tumors showed two structural variants resulting in fusion transcripts: DNAJB1-PRKCA (show PKCa Antibodies) and CLPTM1L (show CLPTM1L Antibodies)-GLIS3 (show GLIS3 Antibodies).
In this cohort of fibrolamellar hepatocellular carcinoma, almost 80% contained the DNAJB1-PRKACA (show PRKACA Antibodies) fusion transcript.
Authors identified DNAJB1 as a negative regulator of PDCD5 (show PDCD5 Antibodies)-mediated apoptosis and found that the apoptosis network of PDCD5 (show PDCD5 Antibodies) regulates cancer cell death.
We also found that, despite an initial report to the contrary, the human homolog of Sis1, Hdj1, is capable of [PSI+] prion (show PRNP Antibodies) propagation in place of Sis1
HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells.
Studies with specific phosphoantibodies indicate that MK5 (show MAPKAPK5 Antibodies) phosphorylates Hsp40/DnaJB1 in vivo at Ser (show SIGLEC1 Antibodies)-149 or/and Ser (show SIGLEC1 Antibodies)-151 and Ser (show SIGLEC1 Antibodies)-171 in the C-terminal domain of Hsp40/DnaJB1.
our data indicate that the MLF/DnaJ-1-dependent increase in Lz level allows the repression of Notch (show NOTCH1 Antibodies) expression and signaling to prevent aberrant blood cell development. Thus our findings establish a functional link between MLF and the co-chaperone DnaJ-1 to control RUNX transcription factor activity and Notch (show NOTCH1 Antibodies) signaling during blood cell development in vivo.
Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 (show ATXN3 Antibodies) has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3 (show ATXN3 Antibodies)-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S
Through DnaJ-1, our data connect ataxin-3 (show ATXN3 Antibodies) and Rad23 to protective processes involved with protein folding rather than increased turnover of toxic polyQ species.
Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A (show CACNA1A Antibodies)
HSP40 and HSP110 (show HSPH1 Antibodies) function together in protein homeostasis control.
A high positive correlation was found between the levels of Hsp40 expression and scores of basal and induced thermotolerance, implying a significant contribution of Hsp40 gene in thermoadaptation.
Overexpression of DNAJB1 relieves TDP-43 (show TARDBP Antibodies) mediated toxicity in primary rodent cortical neurons.
a biochemical link between Hsp40 expression and Abeta (show APP Antibodies)(42) proteostasis that is cell specific
Hsc70 (show HSPA8 PLURAL_@19415@), Hdj1 and Hdj2 (show DNAJA1 PLURAL_@19415@) interact with soluble and fibrillar alpha-synuclein (show SNCA PLURAL_@19415@)
Hsp40, which was constitutively expressed in postmeiotic spermatogenic cells in testis, was integrated into spermatozoa as two components, that is, sperm head and tail of rodent spermatozoa.
HSP-40 expression was detected after 2 h of heat stress
a role for Hsp40 crosstalk with CSPalpha in neuroprotection.
This is a paper that uses purification techiques to find the following: Hsc40 (show DNAJB5 Antibodies), a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 (show HSPA8 Antibodies) in mammalian cells.
Probably involved in mitochondrial protein import. Is also required for efficient translocation of pre-pro-alpha-factor. Involved in heme regulation of HAP1, as a component of the high- molecular-weight (HMC) complex.
, dnaJ like1
, Hsp40 protein
, DnaJ protein
, heat shock protein 40
, DnaJ (Hsp40) homolog, subfmaily B, member 1
, dnaJ homolog subfamily B member 1
, dnaJ protein homolog 1
, heat shock 40 kDa protein 1
, heat shock 40kD protein 1
, human DnaJ protein 1
, radial spoke 16 homolog B