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Dystrophin Proteins (DMD)

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. Additionally we are shipping Dystrophin Antibodies (103) and Dystrophin Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DMD 1756 P11532
Rat DMD DMD 24907  
DMD 13405 P11531
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Top Dystrophin Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DMD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Dystrophin (DMD) Interaction Partners

Xenopus laevis Dystrophin (DMD) interaction partners

  1. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.

Zebrafish Dystrophin (DMD) interaction partners

  1. Forced expression of embryonic dystrophin in zebrafish using an exon-skipping approach severely impairs the mobility and muscle architecture.

  2. Spatio-temporal differences in dystrophin dynamics at mRNA and protein levels have been revealed using a novel reporter system.

  3. Data indicate that ataluren (0.1-1 muM, 3-5 dpf) improved contractile function (~60% improvement of force at 0.5 muM) and dystrophin expression.

  4. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.

  5. early expression of the short carboxyl-terminal dystrophin transcript, with expression of the full length muscle transcript occurring during myogenesis.

  6. Data suggest that dystrophin functions in regulation of calcium signaling during early stages of slow muscle cell differentiation; calcium signaling in these cells coincide with first spontaneous contractions of embryonic trunk.

  7. analysis of the dystrophin associated protein complex in zebrafish

  8. Data suggest that the progressive muscle degeneration phenotype of dystrophin mutant zebrafish embryos is caused by the failure of embryonic muscle end attachments.

  9. Dystrophin family gene expression in zebrafish is reported.

  10. reduction of dystrophin, dystroglycan and sarcoglycan (show SGCD Proteins) at translational level in embryos with overexpressed myostatin2

Fruit Fly (Drosophila melanogaster) Dystrophin (DMD) interaction partners

  1. Dys protein regulates tarsal joint formation in response to Notch (show NOTCH1 Proteins) activity during Drosophila leg development.

  2. The findings suggest that the signaling functions of Dystrophin protein are able to ameliorate dilated cardiomyopathy, and thus might help to improve heart muscle function in micro-Dystrophin-based gene therapy approaches.

  3. Nrk, mbl, capt and Cam genetically interact with dystrophin and/or dystroglycan in the process of axon path-finding in the eye.

  4. only dystroglycan, but not dystrophin deficiency causes myodegeneration induced by energetic stress suggesting that dystroglycan might be a component of the low-energy pathway and act as a transducer of energetic stress in normal and dystrophic muscles

  5. Dystrophin and the Rho GTPase (show RACGAP1 Proteins) crossveinless-c signaling pathway likely interact at the postsynaptic side of the NMJ to maintain synaptic homeostasis.

  6. Lack of the large dystrophin isoforms in the postsynaptic muscle cell leads to elevated evoked neurotransmitter release from presynaptic terminals.

  7. Our results indicate the existence of at least two possibly separate roles of dystrophin in muscle, maintaining synaptic homeostasis and preserving the structural stability of the muscle.

  8. The det locus encodes Drosophila dys, which acts with other components of the DAPC to influence intercellular signalling in developing wing veins.

  9. Possibility that Dp186 modulates other non-Gbb/Wit-dependent retrograde signaling pathways required to maintain normal synaptic physiology.

Human Dystrophin (DMD) interaction partners

  1. Detected are the expression of endogenous exons 44-56 connected mRNA transcript of the DMD using total RNAs derived from human normal skeletal muscle by reverse transcription polymerase chain reaction and identified are a total of eight types of multiple exon skipping products around the mutation hotspot.

  2. Thus using NGS we have identified a pathogenic DMD mutation from degraded DNA and low-level somatic mosaicism, which would have been overlooked using Sanger sequencing.

  3. Four nonsense, one frameshift and two splice site mutations as well as two missense variants have been found in dystrophin gene in Iranian Duchenne and Becker muscular dystrophy patients.

  4. Four missense mutations (p.Arg2937Gln, p.Asp882Gly, p.Lys2366Gln, and p.Arg1745His) that are known multiple-polymorphic sites were found in the coding region of the DMD gene. A hemizygous splicing mutation IVS44ds +1G-A (c.6438 +1G>A) was located in intron 44.

  5. Results provide evidence for recursive splicing in the dystrophin transcript and that the order at which introns are removed is not consecutive.

  6. DMD mutations affecting different DMD isoforms associate with characteristically abnormal scotopic ERGs and severe neurodevelopmental problems in Duchenne muscular dystrophy patients.

  7. DMD gene mutations may be suspected in girls child with persistently elevated levels of creatine kinase and scoliosis, calf hypertrophy, or myopathic pattern at electromyography.

  8. the deletion patterns and distribution characteristics of the dystrophin gene in a Chinese population of patients with Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy, are reported.

  9. Males with mutations at the 3' end of the DMD gene affecting all protein isoforms have higher rates of intellectual disability and clusters of neurodevelopmental, emotional, and behavioural symptoms in Duchenne muscular dystrophy.

  10. Study determined the frequency of dystrophin gene alterations in Iranian Duchenne and Becker muscular dystrophies patients using two new proposed sets of primer pairs of M-PCR to facilitate further mutation detection in patients and their families

Pig (Porcine) Dystrophin (DMD) interaction partners

  1. Data indicate that skeletal muscles from with a missense mutation in the dystrophin gene is associated with muscle histophatology.

Mouse (Murine) Dystrophin (DMD) interaction partners

  1. Dp71Delta78-79 dystrophin mutant stimulates neurite outgrowth in cultured neuronal cells via upregulation and phosphorylation of HspB1 (show HSPB1 Proteins).

  2. this study provided evidence that the Dystrophin Dp71, a membrane-associated cytoskeletal protein and the main DMD gene product in the retina, regulates astrocyte morphology and density and is associated with subsequent normal blood vessel development

  3. The novel dystrophin reporter mouse provides a valuable tool for direct visualization of dystrophin expression and will allow the study of dystrophin expression in vivo and in vitro in various tissues by live cell imaging.

  4. Dystrophin-based therapy improves fragility of the dystrophic skeletal muscle by preventing reduction in muscle excitability.

  5. absence of dystrophin in an ApoE (show APOE Proteins)-null background results in attenuated atherosclerotic plaque development, accompanied by an increased proportion of differentiated SMCs and decreased proportion of T cells in plaques of an inflammatory phenotype.

  6. Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.

  7. We observed a significant increase in the proportion of dystrophin-positive SMFs in group of mdx mice radiation chimera 5 Gy and 3 Gy which was additionally exposed in Ca(2 (show CA2 Proteins)+)-MF in comparison with the control mdx mice

  8. The full-length brain dystrophin appears to play a role during acquisition of associative learning and general processes involved in memory consolidation, but no overt involvement in working memory and/or executive functions.

  9. These data define the dystrophin restoration levels required to slow down or prevent disease progression and improve overall muscle function once a dystrophic environment has been established in the mdx mouse model

  10. This detailed evaluation of the SMT C1100 drug series strongly endorses the therapeutic potential of utrophin modulation as a disease modifying therapeutic strategy for all Duchenne muscular dystrophy patients irrespective of their dystrophin mutation.

Dystrophin (DMD) Protein Profile

Protein Summary

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix.

Gene names and symbols associated with Dystrophin Proteins (DMD)

  • dystrophin (DMD)
  • dystrophin (Dmd)
  • dystrophin (dmd)
  • Dystrophin (Dys)
  • dystrophin, muscular dystrophy (Dmd)
  • BMD protein
  • cb664 protein
  • CG7240 protein
  • CG7243 protein
  • CG7344 protein
  • CG17750 protein
  • CG31175 protein
  • CG34157 protein
  • CMD3B protein
  • det protein
  • DKFZp459C1629 protein
  • DKFZp468A1620 protein
  • DLP protein
  • DLP1 protein
  • DLP2 protein
  • DLP3 protein
  • DLP186 protein
  • dmd protein
  • dmDLP protein
  • dmDp186 protein
  • dmDys protein
  • Dmel\\CG34157 protein
  • DNADMD1 protein
  • Dp71 protein
  • Dp117 protein
  • Dp186 protein
  • Dp205 protein
  • Dp427 protein
  • DXS142 protein
  • DXS164 protein
  • DXS206 protein
  • DXS230 protein
  • DXS239 protein
  • DXS268 protein
  • DXS269 protein
  • DXS270 protein
  • DXS272 protein
  • DXSmh7 protein
  • DXSmh9 protein
  • dys protein
  • GI3046716 protein
  • IDLP protein
  • im:6911785 protein
  • mdx protein
  • MGC79631 protein
  • MGC83347 protein
  • pke protein
  • RATDMD protein
  • zfDYS protein
  • zgc:110165 protein

Protein level used designations for Dystrophin Proteins (DMD)

dystrophin , Duchenne muscular dystrophy , dystrophin isoform Dp116 , sap , sapje , CG34157-PA , CG34157-PB , CG34157-PC , CG34157-PD , CG34157-PE , CG34157-PF , CG34157-PG , CG34157-PH , CG34157-PI , CG34157-PJ , CG34157-PK , CG34157-PL , Dys-PA , Dys-PB , Dys-PC , Dys-PD , Dys-PE , Dys-PF , Dys-PG , Dys-PH , Dys-PI , Dys-PJ , Dys-PK , Dys-PL , Dystrophin-like protein 1 , Dystrophin-like protein 186 , Dystrophin-like protein 2 , Dystrophin-like protein 3 , detached , dystrophin Dp186 , dystrophin (muscular dystrophy, Duchenne and Becker types) , dystrophin Dp71 isoform , RNDNADMD1 , apodystrophin-3 , apodystrophin-I , dystrophin transcript variant Dp71e , dystrophin, muscular dystrophy , X-linked muscular dystrophy

100051515 Equus caballus
708073 Macaca mulatta
399334 Xenopus laevis
100172693 Pongo abelii
465557 Pan troglodytes
493417 Xenopus (Silurana) tropicalis
100174396 Pongo abelii
100329118 Xenopus (Silurana) tropicalis
449606 Pan troglodytes
445738 Ciona intestinalis
83773 Danio rerio
42327 Drosophila melanogaster
100406331 Callithrix jacchus
1756 Homo sapiens
606758 Canis lupus familiaris
24907 Rattus norvegicus
396236 Gallus gallus
100727002 Cavia porcellus
497636 Sus scrofa
540755 Bos taurus
101119444 Ovis aries
13405 Mus musculus
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