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SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Antibodies (102) and SIAH1 Proteins (9) and many more products for this protein.
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Results showed that SIAH1 and PTP4A1 (show PTP4A1 ELISA Kits) expression was regulated by mir (show MLXIP ELISA Kits)-944 in breast cancer cells. miR (show MLXIP ELISA Kits)-944 binds directly the 3 UTR (show UTS2R ELISA Kits) of their promotor region.
Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (show WNT2 ELISA Kits)-induced Axin (show AXIN1 ELISA Kits) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 ELISA Kits) through interacting with a VxP motif in the GSK3 (show GSK3b ELISA Kits)-binding domain of Axin (show AXIN1 ELISA Kits), and this function of SIAH is counteracted by GSK3 (show GSK3b ELISA Kits) binding to Axin (show AXIN1 ELISA Kits).
results suggest that CacyBP/SIP (show CACYBP ELISA Kits) is involved in regulation of the Hsp90 chaperone (show HSP90 ELISA Kits) machinery
PINK1 disease mutants failed to recruit synphilin-1 (show SNCAIP ELISA Kits) and did not activate mitophagy, indicating that PINK1-synphilin-1 (show SNCAIP ELISA Kits)-SIAH-1 represents a new parkin (show PARK2 ELISA Kits)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.
Results suggest that activated STAT3 (show STAT3 ELISA Kits) regulates active beta-catenin (show CTNNB1 ELISA Kits) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (show CTNNB1 ELISA Kits) in HEK293T cells.
Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .
SIAH1 is associated with a tumor promoting role in breast cancer.
In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.
Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.
Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
E3 ubiquitin-protein ligase Siah1
, E3 ubiquitin-protein ligase SIAH1
, seven in absentia homolog 1
, seven in absentia 1A
, seven in absentia-like protein 1