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ELANE Proteins

(Elastase, Neutrophil Expressed (ELANE))
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
ELANE Protein (AA 168-267) (GST tag) ELANE Protein (AA 168-267) (GST tag) ELANE Protein (AA 168-267) (GST tag) (ABIN1352646)

ELANE Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

ELANE Protein (AA 30-267) (His tag) ELANE Protein (AA 30-267) (His tag) ELANE Protein (AA 30-267) (His tag) (ABIN3079274)

Crystallography grade ELANE Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

ELANE Protein (AA 27-265) (His tag) ELANE Protein (AA 27-265) (His tag) ELANE Protein (AA 27-265) (His tag) (ABIN3122112)

Crystallography grade ELANE Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

ELANE Proteins by Grade

Find ELANE Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

ELANE Proteins by Origin

Find ELANE Proteins for a variety of species such as anti-Human ELANE, anti-Mouse ELANE, anti-Dog ELANE. The species listed below are among those available. Click on a link to go to the corresponding products.

ELANE Proteins by Source

Here you will find ELANE Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ELANE Proteins by Protein Type

Here you can find ELANE Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

ELANE Proteins by Application

Find ELANE Proteins validated for a specific application such as SDS, WB, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

ELANE Proteins by Biological Activity

Find ELANE Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular ELANE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352646
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079274
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3122112
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source
Validations
Cat. No. ABIN1048116
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389194
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424920
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389191
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389200
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human
Validations
Cat. No. ABIN7507609
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389197
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709463
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713426
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6238750
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6122495
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6122499
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ELANE Proteins

Bolatchiev, Baturin, Bazikov, Maltsev, Kunitsina: "Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo." in: Fundamental & clinical pharmacology, Vol. 34, Issue 1, pp. 102-108, (2020) (PubMed).

Luyendyk, Shaw, Green, Maddox, Ganey, Roth: "Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine." in: The Journal of pharmacology and experimental therapeutics, Vol. 314, Issue 3, pp. 1023-31, (2005) (PubMed).

Aliases for ELANE Proteins

elastase, neutrophil expressed (ELANE) Proteins
elastase, neutrophil expressed (Elane) Proteins
proteinase 3 (prtn3) Proteins
ELA2 Proteins
Ela2 Proteins
ela2 Proteins
ELANE Proteins
F430011M15Rik Proteins
GE Proteins
HLE Proteins
HNE Proteins
NE Proteins
PMN-E Proteins
SCN1 Proteins
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