Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) ELISA Kits

The protein encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. Additionally we are shipping ERAP1 Antibodies (61) and ERAP1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ERAP1 51752 Q9NZ08
ERAP1 80898 Q9EQH2
ERAP1 80897 Q9JJ22
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Top ERAP1 ELISA Kits at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for ERAP1 Interaction Partners

Human Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. Our results suggest that normal levels of ERAP1 reduce the accumulation of aberrant and disulfide-linked forms of HLA-B27 in monocytes, and thus help to maintain the integrity of cell surface HLA-B27 complexes.

  2. The alterations in the nature and affinity of HLA-B*51.peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with Behcet's disease.

  3. One ERAP1 protein allotype with five non-ancestral amino acids was recessively associated with Behcet's disease. The ERAP1 association was absent in individuals who lacked HLA-B*51. Individuals who carry HLA-B*51 and who are also homozygous for the haplotype had an increased disease odds compared with those with neither risk factor.

  4. Electrostatic interactions between domains II and IV in ERAP1 are crucial for driving a conformational change that regulates the structural integrity of the catalytic site.

  5. analysis of genotype and haplotype frequencies of four coding, nonsynonymous ERAP1 SNPs, rs26653G > C, rs26618T > C, rs30187C > T, and rs27044C > G, in non-small cell lung carcinoma occurring in two genetically distant populations, Chinese and Poles

  6. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease

  7. The ERAP1 rs27044/rs30187 haplotype C/T is associated with lower risk of extraspinal disease and systemic inflammation in Nordic AS patients but has no impact on IL-6 (show IL6 ELISA Kits) or TNF (show TNF ELISA Kits) levels.

  8. The ERAP1 polymorphisms are associated with the development of ankylosing spondylitis in Europeans and East Asians. [review & meta-analysis]

  9. ERAP1 gene rs27434 and rs7711564 polymorphisms may increase the risk of ankylosing spondylitis (AS).

  10. Suggest ERAP1 rs27434 SNP is associated with ankylosing spontylitis in Zhejiang Han Chinese population.

Mouse (Murine) Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. we have shown that the loss of ERAAP leads to shifts in the nature and lengths of peptides presented by MHC I molecules on the cell surface

  2. results suggest that several aminopeptidases play important roles in the maximum synthesis of NO in activated macrophages in a substrate peptide-dependent manner and ERAP1 is one of the aminopeptidases involved in the NO synthesis

  3. Data show that endoplasmic reticulum protein 44 (ERp44 (show ERP44 ELISA Kits)) forms a mixed disulfide bond with aminopeptidase (show ANPEP ELISA Kits) ERAP1 and controls the release of ERAP1 in a redox-dependent manner to control blood pressure.

  4. This study clarifies ERAP1's role in shaping immunodominance through creation and destruction of peptides in vivo and demonstrates the functional significance of ERAP1 in modulating T-cell killing based upon this role.

  5. These results suggest that secretion of ERAP1 is mediated by toll (show TLR4 ELISA Kits)-like receptors via induction of intermediate cytokines

  6. ERAP1 directly alters peptide binding and presentation by HLA-B27, thus demonstrating a potential pathogenic mechanism in ankylosing spondylitis.

  7. Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. ERAAP defined the characteristic amino termini of canonical MHC I peptides.

  8. MHC class Ib-restricted cytolytic effector cells specifically eliminated ERAAP-deficient cells in vitro and in vivo.

  9. endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma (show IFNG ELISA Kits)

  10. ERAAP silencing results in MHC-I peptide-loading defects eliciting rejection of the murine T-cell lymphoma RMA in syngeneic mice

ERAP1 Antigen Profile

Antigen Summary

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with ERAP1

  • endoplasmic reticulum aminopeptidase 1 (ERAP1) antibody
  • endoplasmic reticulum aminopeptidase 1 (erap1) antibody
  • zgc:56194 (zgc:56194) antibody
  • type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (ARTS-1) antibody
  • type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (LOC100352256) antibody
  • endoplasmic reticulum aminopeptidase 1 (Erap1) antibody
  • A-LAP antibody
  • ALAP antibody
  • Appils antibody
  • ARTS-1 antibody
  • Arts1 antibody
  • DKFZp469C044 antibody
  • ERAAP antibody
  • ERAAP1 antibody
  • MGC166160 antibody
  • PILS-AP antibody
  • PILSA antibody
  • PILSAP antibody

Protein level used designations for ERAP1

endoplasmic reticulum aminopeptidase 1 , endoplasmic reticulum aminopeptidase 1-like , type 1 tumor necrosis factor receptor shedding aminopeptidase regulator , adipocyte-derived leucine aminopeptidase , aminopeptidase PILS , aminopeptidase regulator of TNFR1 shedding , endoplasmic reticulum aminopeptidase associated with antigen processing , puromycin-insensitive leucyl-specific aminopeptidase , A-LAP , ARTS-1 , PILS-AP , VEGF-induced aminopeptidase , ER-aminopeptidase 1 , leucyl-specific aminopeptidase PILS

GENE ID SPECIES
427122 Gallus gallus
488898 Canis lupus familiaris
514617 Bos taurus
100010465 Monodelphis domestica
100173512 Pongo abelii
100391536 Callithrix jacchus
100477111 Ailuropoda melanoleuca
100496768 Xenopus (Silurana) tropicalis
100565356 Anolis carolinensis
100602026 Nomascus leucogenys
393175 Danio rerio
471835 Pan troglodytes
699996 Macaca mulatta
100352256 Oryctolagus cuniculus
51752 Homo sapiens
80898 Mus musculus
80897 Rattus norvegicus
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