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Enolase 1, (Alpha) Proteins (ENO1)

ENO1 encodes alpha-enolase, one of three enolase isoenzymes found in mammals.

list all proteins Gene Name GeneID UniProt
Human ENO1 ENO1 2023 P06733
Rat ENO1 ENO1 24333 P04764
Mouse ENO1 ENO1 13806 P17182
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More Proteins for Enolase 1, (Alpha) (ENO1) Interaction Partners

Human Enolase 1, (Alpha) (ENO1) interaction partners

  1. An immune-modulatory role has been proposed for surface alpha-enolase and our findings of decreased expression suggest that deficits in surface alpha-enolase merit investigation in the context of immune dysfunction during ageing and vascular disease

  2. Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase

  3. ENO1 was demonstrated to be up-regulated by HIF-1alpha in retinal pigment epithelial cells in response to hypoxia, without influencing VEGF secretion.

  4. In this study, ENO1 silencing significantly reduced cell glycolysis, proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo by modulating p85 suppression.

  5. alpha-Enolase increases after injury and may activate pulmonary endothelial cells and prime PMNs through plasmin (show PLG Proteins) activity and PAR-2 (show F2RL1 Proteins) activation

  6. High ENO1 expression is associated with invasiveness of pancreatic cancer.

  7. tRK1 (show NTRK1 Proteins) forms a complex with human enolases and interacts with tRK1 (show NTRK1 Proteins) and human pre-lysyl-tRNA synthetase (show KARS Proteins) (preKARS2)

  8. The association of ENO1 and GPI (show GNPDA1 Proteins) with postthaw sperm viability and motility was confirmed using Pearson's linear correlation. ENO1 and GPI (show GNPDA1 Proteins) can be used as markers of human sperm freezability before starting the cryopreservation procedure.

  9. This study showed that ENO1 is responsible for non-small cell lung cancer proliferation and metastasis

  10. ENO1 induces gene expression, lactate production, cell proliferation and migration and can be negatively regulated by FBXW7 (show FBXW7 Proteins) at the posttranslational level.

Cow (Bovine) Enolase 1, (Alpha) (ENO1) interaction partners

  1. ENO1, VDAC2 (show VDAC2 Proteins), and UQCRC2 (show UQCRC2 Proteins) were significantly correlated with individual fertility in bulls.

Mouse (Murine) Enolase 1, (Alpha) (ENO1) interaction partners

  1. Pre-immunization with ENO1 or its immunodominant peptide pEP1 (show CNDP2 Proteins) reduces CIA (show NCOA5 Proteins) severity at the clinical, immunological and histological levels

  2. a Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-driven functional role of ENO1 and PDIA3 (show PDIA3 Proteins) in alveolar epithelial cell plasticity in lung injury and repair, is reported.

  3. Enolase is a new target of liver X receptors.

  4. Alpha-enolase is upregulated on the cell surface and responds to plasminogen (show PLG Proteins) activation in mice expressing a 133p53alpha mimic

  5. MBP1 inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 to reduce Ab pathology and improve behavioral performance.

  6. These data show a multiantibody composition in lupus nephritis, where IgG2 autoantibodies against alpha-enolase and annexin AI predominate in the glomerulus and can be detected in serum.

  7. These results demonstrate the novel requirement of alpha-enolase for restoring homeostasis of injured muscle tissue, by controlling the pericellular localization of plasmin (show PLG Proteins) activity.

  8. ENO1-positive monocytes and macrophages are found in arthritic ankle tissues of mice with collagen-induced arthritis.

  9. enolase 1 and calreticulin (show CALR Proteins) are important proteins in regulating the differentiation and functions of bone marrow mast cells

  10. By concentrating and enhancing plasmin (show PLG Proteins) generation on the cell surface, alpha-enolase-type plasminogen (show PLG Proteins) receptor is an important component of skeletal myogenesis.

Enolase 1, (Alpha) (ENO1) Protein Profile

Protein Summary

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.

Gene names and symbols associated with Enolase 1, (Alpha) Proteins (ENO1)

  • enolase1 (eno1)
  • enolase 1, (alpha) (ENO1)
  • Alpha-enolase (enoa)
  • enolase 1 (Eno1)
  • alpha-enolase (LOC100499608)
  • enolase 1, (alpha) (eno1-b)
  • enolase 1, (alpha) (Eno1)
  • enolase 1, alpha non-neuron (Eno1)
  • enolase 1a, (alpha) (eno1a)
  • 0610008I15 protein
  • AL022784 protein
  • Eno-1 protein
  • eno1 protein
  • eno1b protein
  • eno1l1 protein
  • MBP-1 protein
  • mpb1 protein
  • Nne protein
  • pENO1 protein
  • Pgh1 protein
  • pph protein
  • wu:fi32b03 protein
  • wu:fk58e02 protein
  • zgc:73152 protein

Protein level used designations for Enolase 1, (Alpha) Proteins (ENO1)

2-phospho-D-glycerate hydro-lyase 1 , 2-phosphoglycerate dehydratase 1 , enolase , enolase 1 , alpha-enolase , 2-phospho-D-glycerate hydro-lyase , NNE , non-neural enolase , Alpha-enolase , MYC promoter-binding protein 1 , alpha enolase like 1 , enolase-alpha , phosphopyruvate hydratase , plasminogen-binding protein , tau-crystallin , 2-phosphoglycerate dehydratase , enolase 1 b (alpha) , HAP47 , alpha enolase , enolase 1, alpha non-neuron , 2-phospho-D-glycerate hydrolase , c-Myc promoter binding protein , enolase 1, (alpha)

732811 Zea mays
457913 Pan troglodytes
100173448 Pongo abelii
100194865 Salmo salar
100306968 Cavia porcellus
100499608 Oncorhynchus mykiss
709378 Macaca mulatta
2023 Homo sapiens
380298 Xenopus laevis
396017 Gallus gallus
479597 Canis lupus familiaris
281141 Bos taurus
24333 Rattus norvegicus
406872 Sus scrofa
13806 Mus musculus
334116 Danio rerio
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