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Eomesodermin Proteins (EOMES)

EOMES encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. Additionally we are shipping EOMES Antibodies (91) and EOMES Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EOMES 8320 O95936
Rat EOMES EOMES 316052  
EOMES 13813 O54839
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Top EOMES Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

EOMES Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Eomesodermin (EOMES) Interaction Partners

Zebrafish Eomesodermin (EOMES) interaction partners

  1. Smad2 (show SMAD2 Proteins) and Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa forms a general component of the Smad2 (show SMAD2 Proteins) signalling complex in zebrafish.

  2. Eomesa has a strictly maternal role in the initiation of epiboly, and is required for normal expression of the endoderm markers sox32, bon and og9x (show SEBOX Proteins); however it is not essential for endoderm formation.

  3. Eomes is a Nodal-transducing factor that acts, directly and indirectly, in concert with FoxH1 (show FOXH1 Proteins) to carry out all Nodal-dependent processes during early mesendoderm specification.

  4. Eomes plays a role in specifying the embryonic organizer.

  5. regulates the expression of a zygotic homeobox (show PRRX1 Proteins) transcription factor mtx2 (show MTX2 Proteins)

  6. Results suggest that eomesodermin promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcriptional activating complex on the casanova promoter.

  7. These results suggest that both Eomes genes are involved in the zebrafish immune response, particularly in lymphocyte function as has been found in mammals.

Human Eomesodermin (EOMES) interaction partners

  1. EOMES expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56 (show NCAM1 Proteins)+ cell dysregulation.

  2. we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib.

  3. Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis.

  4. the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects.

  5. This study showed that EOMES (rs2724509; flanking) associated with Alzheimer disease.

  6. This study supports the concept that poor human viral-specific CD8 (show CD8A Proteins)(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes

  7. Report a global loss of 5hmC identified three new genes (ECM1 (show ECM1 Proteins), ATF5 (show ATF5 Proteins), and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression.

  8. HHEX (show HHEX Proteins) promotes hepatic specification by repressing EOMES expression.

  9. CD127 (show IL7R Proteins) is downregulated at a transcriptional level in memory CD8 (show CD8A Proteins) T cells in association with upregulation of Eomes expression in HIV infected patients.

  10. The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease.

Cow (Bovine) Eomesodermin (EOMES) interaction partners

  1. as conceptuses attach to the uterine epithelium, IFNT gene transcription is down-regulated by an increase in EOMES expression and EOMES-CREBBP (show CREBBP Proteins) binding in the attached trophoblast cells.

Mouse (Murine) Eomesodermin (EOMES) interaction partners

  1. Demonstrate by using the T-box brain-2(Cre) mouse line that progenitor cells derived cells contribute 67.5% of glutamatergic but not GABAergic or astrocytic cells to all cortical layers including the earliest generated subplate zone.

  2. a critical role for IRF4 (show IRF4 Proteins) in regulating protective anti-viral CD8 (show CD8A Proteins)+ T cell responses by ensuring a balanced ratio of T-bet to Eomes

  3. Eomes expression is a key determinant of conventional NK versus Type 1 helper Innate Lymphoid Cell maturation following lineage specification.

  4. T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset experimental autoimmune encephalomyelitis.

  5. find that while stimulation of CD27 (show CD27 Proteins) in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8 (show CD8A Proteins)(+) T-cell responses to OVA immunization

  6. The data identify a novel role for Eomes in CD4 (show CD4 Proteins)+ T cells and indicate that Eomes expression may act by limiting Foxp3 (show FOXP3 Proteins) induction, which may contribute to the association of EOMES to susceptibility to multiple sclerosis.

  7. type I interferon (show IFNA Proteins) signalling in CD8 (show CD8A Proteins)(+) T cells drives Eomes expression.

  8. TGF-beta (show TGFB1 Proteins)/tbr2 receptor signaling pathway may be required for prevention of beta cell death after initial cell proliferation following pancreatectomy.

  9. Interleukin-4 (show IL4 Proteins) regulates eomesodermin in CD8 (show CD8A Proteins)+ T cell development and differentiation

  10. Transgenic overexpression of Wnt7b (show WNT7B Proteins) decreased expression of Tbr2 in both progenitor cells and post-mitotic neurons.

EOMES Protein Profile

Protein Summary

This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.

Gene names and symbols associated with Eomesodermin Proteins (EOMES)

  • eomesodermin homolog (Xenopus laevis) (EOMES)
  • eomesodermin (eomes)
  • eomesodermin homolog a (eomesa)
  • eomesodermin homolog (LOC100470077)
  • eomesodermin (EOMES)
  • eomesodermin homolog (LOC100545637)
  • eomesodermin homolog (LOC100602343)
  • eomesodermin homolog (LOC100622125)
  • eomesodermin (Eomes)
  • eomesodermin homolog (Xenopus laevis) (Eomes)
  • C77258 protein
  • eom protein
  • eomes protein
  • TBR-2 protein
  • Tbr2 protein
  • xeomes protein

Protein level used designations for Eomesodermin Proteins (EOMES)

eomesodermin homolog (Xenopus laevis) , eomesodermin , eom-a , eomes1 , eomesodermin homolog , tbr2 , tbr2a , T-box brain protein 2 , T-brain-2

428443 Gallus gallus
470774 Pan troglodytes
100038065 Xenopus (Silurana) tropicalis
100051187 Equus caballus
100431463 Pongo abelii
100532741 Salmo salar
64603 Danio rerio
100470077 Ailuropoda melanoleuca
100524218 Sus scrofa
100545637 Meleagris gallopavo
100602343 Nomascus leucogenys
100622125 Sus scrofa
8320 Homo sapiens
485636 Canis lupus familiaris
316052 Rattus norvegicus
511947 Bos taurus
398065 Xenopus laevis
13813 Mus musculus
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