Ets Variant 6 (ETV6) ELISA Kits

ETV6 encodes an ETS family transcription factor. Additionally we are shipping ETV6 Antibodies (110) and ETV6 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ETV6 2120 P41212
ETV6 312777  
ETV6 14011 P97360
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More ELISA Kits for ETV6 Interaction Partners

Zebrafish Ets Variant 6 (ETV6) interaction partners

  1. Dominant-negative truncated ETV6 with deletions of the ETS (show ETS1 ELISA Kits) domain or the PNT (show ETS2 ELISA Kits) domain interfered with repression by full-length ETV6 and affected expression of early hematopoietic and erythroid markers in embryos.

  2. the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system

Human Ets Variant 6 (ETV6) interaction partners

  1. Data suggest that, for ETV6 (which harbors only a single DNA contact interface for both specific and nonspecific interactions), intersegmental jumping represents a major molecular event that significantly modifies the thermodynamics and kinetics of DNA target search; site-specific DNA binding by ETV6 involves a kinetic intermediate at the cognate sequence.

  2. Our findings suggest ETV6-RUNX1 (show RUNX1 ELISA Kits) is associated with space-time clustering of childhood leukemia (CL) and are consistent with an infection interacting with that oncogene (show RAB1A ELISA Kits) in early life leading to clinical leukemia.

  3. EGFR (show EGFR ELISA Kits) activation leads to the induction of miR (show MLXIP ELISA Kits)-96 expression and suppression of ETV6, which contributes to prostate cancer progression.

  4. we demonstrate the expression of the ETV6-NTRK3 fusion (show NTRK3 ELISA Kits) oncogene (show RAB1A ELISA Kits) in a small subset of inflammatory myofibroblastic tumors

  5. ETV6-NTRK3 (show NTRK3 ELISA Kits) translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly.

  6. We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 (show NTRK3 ELISA Kits) gene fusion

  7. ETV6-ABL1 (show ABL1 ELISA Kits) fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble BCR (show BCR ELISA Kits)-ABL1 (show ABL1 ELISA Kits)-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias. The poor outcome suggests that treatment with tyrosine kinase (show TXK ELISA Kits) inhibitors should be considered for patients with this fusion.

  8. ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions are identified in Spitz tumours and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cgamma1 pathways in melanocytes.

  9. A subset of ALK (show ALK ELISA Kits)-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1 (show ROS1 ELISA Kits), ETV6 or NTRK3 (show NTRK3 ELISA Kits) as a possible oncogenic mechanism.

  10. loss of ETV6 leads to significant overexpression of CLIC5 (show CLIC5 ELISA Kits), which in turn leads to decreased lysosome-mediated apoptosis. Our data suggest that heightened CLIC5 (show CLIC5 ELISA Kits) activity could promote a permissive environment for oxidative stress-induced (show SQSTM1 ELISA Kits) DNA damage accumulation, and thereby contribute to leukemogenesis.

Mouse (Murine) Ets Variant 6 (ETV6) interaction partners

  1. Together with similar observations made in human PAX5 (show PAX5 ELISA Kits)-ETV6(+) B-ALLs, these data identified PAX5 (show PAX5 ELISA Kits)-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development.

  2. ETV6 DNA binding inhibition is established by the stability of its inhibitory helix

  3. Studied the combination of Etv6-RUNX1 (show RUNX1 ELISA Kits) and Pax5 (show PAX5 ELISA Kits)(+/-) alleles, they generated a transplantable B220 (show PTPRC ELISA Kits) + CD19 (show CD19 ELISA Kits)+ B-ALL with a significant disease incidence; RNA-seq analysis showed a gene expression pattern consistent with arrest at the pre-B stage.

  4. In murine models of B-cell progenitors, evidence found that ETV6- RUNX1 (show RUNX1 ELISA Kits) alters the expression of cytoskeletal regulatory genes, resulting in a block of the CDC42 (show CDC42 ELISA Kits) signaling pathway, and compromises the chemotactic response to CXCL12 (show CXCL12 ELISA Kits).

  5. ETV6-SAM (show TTN ELISA Kits) domain interface mutations block ETV6-NTRK3 (show NTRK3 ELISA Kits)-induced cellular transformation

  6. the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS (show ETS1 ELISA Kits) domain

  7. find that both IRS1 (show IRS1 ELISA Kits) and kinase active IGF1R (show IGF1R ELISA Kits) are required for ETV6-NTRK3 (show NTRK3 ELISA Kits) transformation, that tyrosine phosphorylated IRS1 (show IRS1 ELISA Kits) is present in high molecular weight complexes with EN and IGF1R (show IGF1R ELISA Kits), and that EN colocalizes with IGF1R (show IGF1R ELISA Kits) at the plasma membrane

  8. Cytogenetic study of 33 children with ETV6-RUNX1 (show RUNX1 ELISA Kits) positive acute lymphoblastic leukemia predict long term survival.

  9. TEL binding to IRF-8 (show IRF8 ELISA Kits) for recruitment of HDAC3 (show HDAC3 ELISA Kits) is regulated by gamma-interferon (show IFNG ELISA Kits)

  10. the ability of TEL to repress transcription and suppress growth is regulated by sumoylation and nuclear export

ETV6 Antigen Profile

Antigen Summary

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

Gene names and symbols associated with Ets Variant 6 (ETV6) ELISA Kits

  • ets variant gene 6 (TEL oncogene) (etv6) antibody
  • ets variant 6 (ETV6) antibody
  • ets variant 6 (etv6) antibody
  • ets variant 6 (LOC100352251) antibody
  • ets variant 6 (Etv6) antibody
  • ets variant gene 6 (TEL oncogene) (Etv6) antibody
  • ets variant gene 6 (TEL oncogene) (ETV6) antibody
  • AW123102 antibody
  • AW557856 antibody
  • etv-6 antibody
  • id:ibd2308 antibody
  • Tel antibody
  • TEL/ABL antibody

Protein level used designations for Ets Variant 6 (ETV6) ELISA Kits

transcription factor ETV6 , ztel , ets variant gene 6 (TEL oncogene) , TEL oncogene , ets variant 6 , ETS translocation variant 6 , ETS-related protein Tel1 , TEL1 oncogene , translocation-ets-leukemia , ets domain protein

114444 Danio rerio
473366 Pan troglodytes
486685 Canis lupus familiaris
549634 Xenopus (Silurana) tropicalis
100063341 Equus caballus
100352251 Oryctolagus cuniculus
2120 Homo sapiens
312777 Rattus norvegicus
504512 Bos taurus
14011 Mus musculus
395750 Gallus gallus
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