FANCD2/FANCI-Associated Nuclease 1 (FAN1) ELISA Kits

FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. Additionally we are shipping FAN1 Antibodies (34) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FAN1 22909 Q9Y2M0
FAN1 330554 Q69ZT1
Anti-Rat FAN1 FAN1 309256  
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More ELISA Kits for FAN1 Interaction Partners

Human FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. show that DNA repair genes (fan1 (show FSCN1 ELISA Kits) and pms2 (show PMS2 ELISA Kits)) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats

  2. FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.

  3. EXO1 (show EXO1 ELISA Kits) and FEN1 (show FEN1 ELISA Kits) cleaved the substrate at the boundary between the single-stranded 5' flap (show ALOX5AP ELISA Kits) and the duplex, whereas FAN1 (show FSCN1 ELISA Kits) incised it three to four nucleotides in the double-stranded region.

  4. Detected FAN1 (show FSCN1 ELISA Kits) mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.

  5. The crystal structures of human FAN1 (show FSCN1 ELISA Kits) in complex with a 5' flap (show ALOX5AP ELISA Kits) DNA substrate show that two FAN1 (show FSCN1 ELISA Kits) molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap (show ALOX5AP ELISA Kits) for subsequent incision.

  6. In this work, FAN1 (show FSCN1 ELISA Kits)-DNA crystal structures and biochemical data reveal that human FAN1 (show FSCN1 ELISA Kits) cleaves DNA successively at every third nucleotide

  7. Results show that FAN1 (show FSCN1 ELISA Kits) utilizes its nuclease (show DCLRE1C ELISA Kits) activity-in cooperation with the BLM-FANCD2 (show FANCD2 ELISA Kits) complex-to promote replication fork restart and simultaneous suppression of new origin firing.

  8. FAN1 (show FSCN1 ELISA Kits) encodes a DNA repair enzyme (show LIG4 ELISA Kits), thus implicating abnormalities in DNA repair in the susceptibility to schizophrenia or autism

  9. FAN1 (show FSCN1 ELISA Kits) might be a new mitotic substrate of APC (show APC ELISA Kits)/CCdh1 that plays a key role during mitotic exit.

  10. By exome sequencing, we identified mutations in FAN1 (show FSCN1 ELISA Kits) as a cause of karyomegalic interstitial nephritis, a disorder that serves as a model for renal fibrosis.

Mouse (Murine) FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease

  2. Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy

  3. ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.

  4. Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.

FAN1 Antigen Profile

Antigen Summary

This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with FAN1

  • FANCD2/FANCI-associated nuclease 1 (FAN1) antibody
  • FANCD2/FANCI-associated nuclease 1 (Fan1) antibody
  • FANCD2/FANCI-associated nuclease 1 (fan1) antibody
  • 6030441H18Rik antibody
  • fi39f01 antibody
  • KIAA1018 antibody
  • KMIN antibody
  • mtmr15 antibody
  • RGD1566323 antibody
  • si:ch211-163b1.2 antibody
  • si:ch211-201b11.2 antibody
  • wu:fd06a07 antibody
  • wu:fi39f01 antibody

Protein level used designations for FAN1

coiled-coil domain-containing protein MTMR15 , fanconi anemia associated nuclease 1 , fanconi-associated nuclease 1 , myotubularin-related protein 15 , myotubularin related protein 15 , Fanconi-associated nuclease 1

22909 Homo sapiens
330554 Mus musculus
565458 Danio rerio
100481860 Ailuropoda melanoleuca
415383 Gallus gallus
479017 Canis lupus familiaris
100154519 Sus scrofa
508171 Bos taurus
309256 Rattus norvegicus
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