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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping Fat Mass and Obesity-Associated Antibodies (125) and Fat Mass and Obesity-Associated Proteins (11) and many more products for this protein.
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data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to laparoscopic sleeve gastrectomy to help clinicians predicting the weight loss for severely obese patients in short-term follow-up.
The A-allele frequencies (95% CI) of FTO polymorphisms rs8050136 and rs9939609 were 39% (34-44%); 38% (33-43%) and 40% (35-45%); 41% (36-46%), respectively.
The effects of exercise combined with dietary intervention on obesity were associated with the FTO rs9939609 polymorphism in Chinese adolescents and children.
Individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers. [Review, Meta-analysis]
data suggest that FTO SNPs make differential contributions to obesity risk and support the hypothesis that gender differences in the mechanisms involving these variants may contribute to disease development
There is a different evolution of weight loss in obese carriers of the FTO gene variant rs9939609 after bariatric surgery...evident at only 2 y postbariatric surgery, inducing a lower proportion of surgery success and a greater and earlier weight regain.
The young Polish population is characterized by two disparate haplotypes of common FTO gene variants: TCGA (a risk SNP haplotype), and CTAT (a protective haplotype) in terms of body fat distribution.
FTO rs9939609 associated with aortic valve stenosis in German men. Heterozygotes had a significantly lower chance to develop AVS. This was independent of BMI and other variables such as diabetes mellitus.
Presurgery vitamin D levels influence the size of genotype effects of FTO rs9939609 on RYGB surgery-induced weight loss in obese patients.
PPARgamma2 (show PPARG ELISA Kits) (rs1801282) and FTO (rs9939609) are associated with T2D susceptibility.
FTO-dependent N6-methyladenosine demethylation may be affected by betaine.
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL ELISA Kits)-induced transcription.
FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.
FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L ELISA Kits).
FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.
data suggest that IRX3 (show IRX3 ELISA Kits) is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition
FTO silencing did not modify PPARgamma2 (show PPARG ELISA Kits) mRNA levels. Partial reduction of FTO did not influence the first step of 3T3-L1 adipocyte differentiation.
Downregulation was seen only with essential amino-acid deficiency and not with non-essential amino acids. These data suggest that FTO might have a role in the sensing of essential amino-acid availability.
Data suggest that Fto-deficient white adipocytes exhibit some metabolic functions similar to brown adipocytes; expression of Ucp1 (uncoupling protein-1 (show UCP1 ELISA Kits)) is up-regulated and mitochondrial uncoupling is increased in Fto-deficient adipocytes.
Inactivation of the Fto gene impairs dopamine receptor types 2 & 3 control of neuronal activity & behavioral responses. FTO regulates the demethylation of specific mRNAs in vivo, and this activity relates to the control of DA transmission.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 ELISA Kits) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso