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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (143) and FTO Proteins (10) and many more products for this protein.
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This study demonstrated that the rs9939609 (FTO) polymorphism showed a relationship with obesity in the population studied and an interaction with cardiorespiratory fitness (CRF (show CRH ELISA Kits)). Students with low levels of CRF (show CRH ELISA Kits) and the AA genotype have a higher risk of being overweight/obese.
Data show that the splicing effects of alpha-ketoglutarate dependent dioxygenase FTO are dependent on the catalytic activity in vivo and are mediated by N6-methyladenosine (m6A (show GPM6A ELISA Kits)).
FTO variants not only were associated with T2DM, but also some variants had a strong association with apelin (show APLN ELISA Kits) and androgenic hormones profile.
FTO and near MC4R (show MC4R ELISA Kits) variants are associated with obesity measures in Sri (show SRI ELISA Kits) Lankan populations...
Results suggest that the hypomorphic FTO p.A134T variant is associated with thiopurine-induced leukopenia in South Korean patients with inflammatory bowel disease.
The FTO gene polymorphism, rs9939609, was found to be associated with insulin resistance, insulin, triglyceride and adiponectin levels in obese patients with TT variant
Polymorphisms rs9939609 (FTO gene) and rs1424233 (MAF (show MAF ELISA Kits) gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study; these polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model.
analyses revealed strong association of FTO intronic variants (block 8) with overweight in group of men only. We have also identified association of the IRX region with overweight and/or obesity in Polish individuals
The present study shows that FTO gene rs9939609 is a genetic risk factor for metabolic syndrome in the Egyptian population
Increased triglycerides, having one or two minor A alleles for FTO single nucleotide polymorphism rs8050136 and being a smoker were associated with increased risk of alcohol dependence, while increased low-density lipoprotein cholesterol was associated with decreased risk.
The involvement of mTOR (show FRAP1 ELISA Kits)-PGC-1alpha (show PPARGC1A ELISA Kits) pathway in the connection between FTO and muscle differentiation is displayed.
In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (show RPGRIP1L ELISA Kits), and possibly other genes.
FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis
Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.
Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.
Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG ELISA Kits) and PI3K/Akt (show AKT1 ELISA Kits) signaling.
These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 ELISA Kits).
FTO-dependent N6-methyladenosine demethylation may be affected by betaine.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 ELISA Kits) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso