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The protein encoded by FLG is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. Additionally we are shipping Filaggrin Antibodies (48) and Filaggrin Kits (24) and many more products for this protein.
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demonstrated that Id1 (show ID1 Proteins) and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions
FGF receptor 1-mediated anosmin-1 (show KAL1 Proteins) activity plays a crucial role in the continuous remodelling of the adult olfactory bulb.
Fgfr1 (show FGFR1 Proteins) and Fgfr2 (show FGFR2 Proteins) in the palatal and mandibular mesenchyme have roles in regulating shelf medial wall protrusion and growth of the mandible to coordinate the craniofacial tissue movements that are required for palatal shelf elevation
Data suggest that signal transduction via Fgf23 (show FGF23 Proteins)/Fgfr1 (show FGFR1 Proteins) and calcitriol/calcitriol receptor have opposite roles in innate immunity; Fgf23 (show FGF23 Proteins) suppresses arginase-1 (show ARG1 Proteins) expression in macrophages; calcitriol stimulates arginase-1 (show ARG1 Proteins) expression in macrophages.
FGFR1 (show FGFR1 Proteins) has dual functions to directly regulate proximal and distal tubule phosphate and calcium reabsorption, indicating a physiological role of FGFR1 (show FGFR1 Proteins) signaling in both phosphate and calcium homeostasis.
Data demonstrate an essential role for FGFR1 (show FGFR1 Proteins) and FGFR2 (show FGFR2 Proteins) in endothelial cells for cardiac functional recovery and vascular remodeling following in vivo cardiac ischemia-reperfusion injury, without affecting the cardiac hypertrophic response.
Activation of FGFR1 (show FGFR1 Proteins) is essential for the high levels of FGF23 (show FGF23 Proteins) in acute and chronic experimental uremia.
Studied the protein expression of BCL2 (show BCL2 Proteins), FGF-R1, and HSP70 (show HSP70 Proteins) after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.
The results of this study concluded that since the OPC response was not altered in Fgfr1 (show FGFR1 Proteins)/Fgfr2 (show FGFR2 Proteins) dKO mice either after initial demyelination or after chronic demyelination.
a transplantable Wnt1 (show WNT1 Proteins)/inducible fibroblast Arowth factor receptor (FGFR) 1 (show FGFR1 Proteins) mouse mammary tumor model.
FLG (show FGFR1 Proteins) has been, and still remains the major susceptibility gene in patients with AD.
Letter: Knockdown of either filaggrin or loricrin (show LOR Proteins) increases the productions of interleukin (IL)-1alpha, IL-8 (show IL8 Proteins), IL-18 (show IL18 Proteins) and granulocyte macrophage colony-stimulating factor (show CSF2 Proteins) in stratified human keratinocytes.
Supplementation with the PPARalpha (show PPARA Proteins) agonist WY14643 improved the homeostasis and barrier function of filaggrin deficient skin models by normalization of the free fatty acid profile.
Filaggrin genotype does not determine the skin's threshold to UV-induced erythema.
In Iranian patients, this study demonstrated that there was no significant association between polymorphisms of FLG (show FGFR1 Proteins) gene variants and AD.
Filaggrin expression was present in healthy skin
Our findings indicate an association between xerosis and asthma in men independent of atopic dermatitis and FLG (show FGFR1 Proteins) mutations.
Results show that among participants aged over 60 years at baseline, we found statistically significant lower risks of all cancers and NMSC among FLG (show FGFR1 Proteins) mutation carriers.
Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis
Filaggrin polymorphism Pro478Ser Is associated with increased disease severity and staphylococcus aureus colonization in atopic dermatitis patients.
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, basic fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, epidermal filaggrin
, Filaggrin (profilaggrin)
, keratin intermediate filament-associated protein