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The protein encoded by FLG is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. Additionally we are shipping Filaggrin Antibodies (50) and Filaggrin Kits (17) and many more products for this protein.
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FGFR1OP2 (show FGFR1OP2 Proteins)-FGFR1 (show FGFR1 Proteins) fusion in hematopoietic stem cells induced myeloid leukemia (show BCL11A Proteins) and T-cell lymphoma in a mouse model.
MiR (show MLXIP Proteins)-214 was up-regulated in mesenchymal stem cells of osteoporotic mice and down-regulated during osteoblast differentiation of mesenchymal stem cells. FGFR1 (show FGFR1 Proteins) is a direct target of miR (show MLXIP Proteins)-214.
demonstrated that Id1 (show ID1 Proteins) and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions
FGF receptor 1-mediated anosmin-1 (show KAL1 Proteins) activity plays a crucial role in the continuous remodelling of the adult olfactory bulb.
Fgfr1 (show FGFR1 Proteins) and Fgfr2 (show FGFR2 Proteins) in the palatal and mandibular mesenchyme have roles in regulating shelf medial wall protrusion and growth of the mandible to coordinate the craniofacial tissue movements that are required for palatal shelf elevation
Data suggest that signal transduction via Fgf23 (show FGF23 Proteins)/Fgfr1 (show FGFR1 Proteins) and calcitriol/calcitriol receptor have opposite roles in innate immunity; Fgf23 (show FGF23 Proteins) suppresses arginase-1 (show ARG1 Proteins) expression in macrophages; calcitriol stimulates arginase-1 (show ARG1 Proteins) expression in macrophages.
FGFR1 (show FGFR1 Proteins) has dual functions to directly regulate proximal and distal tubule phosphate and calcium reabsorption, indicating a physiological role of FGFR1 (show FGFR1 Proteins) signaling in both phosphate and calcium homeostasis.
Data demonstrate an essential role for FGFR1 (show FGFR1 Proteins) and FGFR2 (show FGFR2 Proteins) in endothelial cells for cardiac functional recovery and vascular remodeling following in vivo cardiac ischemia-reperfusion injury, without affecting the cardiac hypertrophic response.
Activation of FGFR1 (show FGFR1 Proteins) is essential for the high levels of FGF23 (show FGF23 Proteins) in acute and chronic experimental uremia.
Studied the protein expression of BCL2 (show BCL2 Proteins), FGF-R1, and HSP70 (show HSP70 Proteins) after short-time magnetic thermoablative tumor treatment using immunohistochemistry in a human BT474 breast cancer mouse xenograft model.
The study revealed 66 FLG (show FGFR1 Proteins) mutation carriers and demonstrated an association between c.2282del4 deletion and atopic dermatitis development in Russians and Tatars of Volga-Ural region of Russia.
The levels of filaggrin, inflammatory T helper 2 polarizing cytokines (thymic stromal lymphopoietin (TSLP (show TSLP Proteins)) and interleukin 33 (IL-33 (show IL33 Proteins))) and chemokine (C-C motif) ligand 27 (CCL27 (show CCL27 Proteins)), histological severity markers, T and dendritic cell counts in biopsies from lesional skin of severe atopic dermatitis patients with and without filaggrin mutation and healthy skin were quantified. No significant differences were found.
The imbalance between Th1 (show TH1L Proteins) and Th2 polarized immune response seems to extend to Filaggrin homeostasis, through the network of Filaggrin processing enzymes.
Levels of FLG (show FGFR1 Proteins), FLG2 and SPRR3 (show SPRR3 Proteins) mRNAs and proteins were reduced in AD skin.
Data suggest that the c.1360A>G (p.T454A) and c.10363G>T (p.D3455Y) mutations of the filaggrin (FLG) gene may lead to alteration of the structure and function of the FLG (show FGFR1 Proteins) protein and cause ichthyosis (show LBR Proteins) vulgaris in the two families.
Results show a strong association of FLG (show FGFR1 Proteins) loss-of-function mutations was found with doctor-diagnosed CD and to a lesser extent also with self-reported CD, but not with respiratory symptoms or atopy.
Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination.
FLG (show FGFR1 Proteins) has been, and still remains the major susceptibility gene in patients with AD.
Letter: Knockdown of either filaggrin or loricrin (show LOR Proteins) increases the productions of interleukin (IL)-1alpha, IL-8 (show IL8 Proteins), IL-18 (show IL18 Proteins) and granulocyte macrophage colony-stimulating factor (show CSF2 Proteins) in stratified human keratinocytes.
Supplementation with the PPARalpha (show PPARA Proteins) agonist WY14643 improved the homeostasis and barrier function of filaggrin deficient skin models by normalization of the free fatty acid profile.
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, basic fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, epidermal filaggrin
, Filaggrin (profilaggrin)
, keratin intermediate filament-associated protein