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Flotillin 2 Proteins (FLOT2)

The enzyme encoded by FLOT2 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Flotillin 2 Antibodies (82) and Flotillin 2 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FLOT2 2319 Q14254
FLOT2 14252 Q60634
Rat FLOT2 FLOT2 83764 Q9Z2S9
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Top Flotillin 2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast REACT_Crucian Carp His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

FLOT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Flotillin 2 (FLOT2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Flotillin 2 (FLOT2) interaction partners

  1. Flotillin-2 and constitutively active Src42A are also sufficient, when overexpressed at high levels, to inhibit wound-induced transcription in epidermal cells.

Human Flotillin 2 (FLOT2) interaction partners

  1. genetic association study in population of women in Brazil: Data suggest an SNP in promoter of PON1 (show PON1 Proteins) [T(-107)C, rs705379] is associated with variations in serum PON1 (show PON1 Proteins) activity; PON1 (show PON1 Proteins) is higher with CC genotype; high-fat diet down-regulates PON1 (show PON1 Proteins) activity.

  2. No evidence that the Q192R and L55M polymorphisms of PON1 (show PON1 Proteins) impacted on the probability of reaching extreme ages was found although this cannot be completely ruled out.

  3. The AA genotype of the rs854560 SNPs of the PON1 (show PON1 Proteins) gene is associated with increased mortality in patients after myocardial infarction in the subpopulation of patients with lowered glomerular filtration rate.

  4. There was a strong association between polymorphisms of flotillin-2 gene and CAD in the Chinese Han population

  5. toxicogenetics/genetic association study in population in Turkey: Data suggest SNP in PON1 (show PON1 Proteins) (192Q/R) is associated with susceptibility to organophosphate poisoning; plasma ACHE activities of exposed workers vary w/ PON1 (show PON1 Proteins) genotype: 192RR>192QR>192QQ.

  6. PON-1 (show PON1 Proteins) 55 L/M and 192Q/R polymorphisms and allelic variants are not related with the risk for migraine in Turkish people.

  7. Data suggest that serum PON1 (show PON1 Proteins) activity is up-regulated in subjects treated with cholesterol-lowering agents (fibrates with/without statins) in prevention of cardiovascular disease (CVD) in patients at risk for CVD. [META-ANALYSIS, REVIEW]

  8. Leu-9, Tyr (show TYR Proteins)-185, and Tyr (show TYR Proteins)-293 of PON1 (show PON1 Proteins) are importance in binding to HDL (show HSD11B1 Proteins) and catalytic activity.

  9. PON1 (show PON1 Proteins) Q192R polymorphism is likely to be a risk factor for cataract development in Pakistani population while PON1 (show PON1 Proteins) L55M was not found to be associated with cataract.

  10. Flot-2 exerts a pro-neoplastic role in NPC (show NPC1 Proteins) and is involved in tumor progression and metastasis. Moreover, Flot-2 exerts its role through NF-kappaB (show NFKB1 Proteins) and PI3K (show PIK3CA Proteins)/Akt3 (show AKT3 Proteins) signaling.

Mouse (Murine) Flotillin 2 (FLOT2) interaction partners

  1. These results indicated that miR (show MLXIP Proteins)-124 could potentially play a role in caveolin-independent vesicle trafficking and modulation of flotillin-2 expression in mouse acrosome biogenesis.

  2. The role of flotillin 1 (show FLOT1 Proteins) and flotillin 2 in regulating amyloid beta production in a mouse model of cerebral amyloidosis, remains unlear.

  3. Curcumin mediates neurite outgrowth through activation of the reggie-1 pathway.

  4. The genetic ablation of flotillin-2 in a mouse model or its knockdown in cultured cells increases extracellular signal regulated kinase (ERK (show EPHB2 Proteins)) activation.

  5. upregulation of reggie-1 in mammalian neurons provides nerve cells with neuron-intrinsic properties required for axon growth and successful regeneration

  6. flotillins have a role in NPC1L1 (show NPC1L1 Proteins)-mediated cholesterol uptake and NPC1L1 (show NPC1L1 Proteins)-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption

  7. Data suggest that the association between flotillin 1 (show FLOT1 Proteins)/2 microdomains and cortical cytoskeleton has important functions during neutrophil migration, in uropod formation, and in the regulation of myosin IIa.

  8. Reggie-1/flotillin-2 microdomains form independent of actin

  9. Lipid rafts were affected by both the dose and ratio of the beta-glycosphingolipids and the acyl chain length, and these effects were followed by downstream effects on STAT (show STAT1 Proteins) proteins.

  10. copper modulates flotillin-2 association with cholesterol-rich lipid raft domains, and consequently Abeta (show APP Proteins) synthesis is attenuated via copper-mediated inhibition of APP (show APP Proteins) endocytosis

Flotillin 2 (FLOT2) Protein Profile

Protein Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Gene names and symbols associated with Flotillin 2 Proteins (FLOT2)

  • Flotillin-2 (Flo-2)
  • flotillin 2 (flot2)
  • flotillin 2 (FLOT2)
  • flotillin 2 (Flot2)
  • flotillin 2-like (LOC100344093)
  • flotillin-2-like (LOC100856195)
  • flotillin-2-like (LOC100518752)
  • paraoxonase 1 (PON1)
  • AI573412 protein
  • CG11547 protein
  • CG14409 protein
  • CG32593 protein
  • Dmel\\CG32593 protein
  • DmFlo2 protein
  • ECS-1 protein
  • ECS1 protein
  • Esa protein
  • ESA1 protein
  • flo2 protein
  • FLOT2 protein
  • flotillin-2 protein
  • FLO[Dm]-2 protein
  • M17S1 protein
  • MVCD5 protein
  • PON protein
  • reggie-1 protein
  • reggie-2 protein

Protein level used designations for Flotillin 2 Proteins (FLOT2)

CG32593-PA , CG32593-PB , CG32593-PC , CG32593-PD , CG32593-PE , CG32593-PF , CG32593-PG , CG32593-PH , CG32593-PI , CG32593-PJ , CG32593-PK , CG32593-PL , Flo-2-PA , Flo-2-PB , Flo-2-PC , Flo-2-PD , Flo-2-PE , Flo-2-PF , Flo-2-PG , Flo-2-PH , Flo-2-PI , Flo-2-PJ , Flo-2-PK , Flo-2-PL , flotillin , flotillin 2 , flotillin-2 , flotillin2 , flottilin 2 , reggie-1 , reggie1 , flotillin-2-like , Flotillin 2 (epidermal surface antigen 1) , epidermal surface antigen , membrane component chromosome 17 surface marker 1 , membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1) , membrane component chromosome 17 surface marker 1 homolog , REG-1 , reggie1-1 , A-esterase 1 , K-45 , PON 1 , aromatic esterase 1 , arylesterase B-type , esterase A , paraoxonase B-type , serum aryldiakylphosphatase , serum aryldialkylphosphatase 1 , serum paraoxonase/arylesterase 1

32425 Drosophila melanogaster
379990 Xenopus laevis
454537 Pan troglodytes
496443 Xenopus (Silurana) tropicalis
610963 Canis lupus familiaris
100072090 Equus caballus
100402699 Callithrix jacchus
100452158 Pongo abelii
100479641 Ailuropoda melanoleuca
100549413 Meleagris gallopavo
100580465 Nomascus leucogenys
2319 Homo sapiens
615679 Bos taurus
14252 Mus musculus
83764 Rattus norvegicus
417579 Gallus gallus
100721332 Cavia porcellus
100344093 Oryctolagus cuniculus
100856195 Canis lupus familiaris
100518752 Sus scrofa
5444 Homo sapiens
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