Flotillin 2 Proteins (FLOT2)

The enzyme encoded by FLOT2 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Flotillin 2 Antibodies (87) and Flotillin 2 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FLOT2 2319 Q14254
FLOT2 14252 Q60634
Rat FLOT2 FLOT2 83764 Q9Z2S9
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Top Flotillin 2 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,193.67
Details
Yeast REACT_Crucian Carp His tag   1 mg Log in to see 60 to 71 Days
$3,193.67
Details

FLOT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Flotillin 2 (FLOT2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Flotillin 2 (FLOT2) interaction partners

  1. Flotillin-2 and constitutively active Src42A are also sufficient, when overexpressed at high levels, to inhibit wound-induced transcription in epidermal cells.

Human Flotillin 2 (FLOT2) interaction partners

  1. Data suggest that paraoxonases (PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), PON3 (show PON3 Proteins)) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 (show PON1 Proteins) activities are associated with poor survival in patients with severe sepsis. [REVIEW]

  2. We demonstrated that LXR (show NR1H3 Proteins) stimulation decreases mRNA and protein expression of FLOT2 and DHHC5 in MCF-7 cells. LXR (show NR1H3 Proteins) stimulation also reduces Akt (show AKT1 Proteins) phosphorylation and its localization at the plasma membrane

  3. stratification by PON1 (show PON1 Proteins) Q192R phenotype improved the reliability characteristics of FF PON1 (show PON1 Proteins) enzymes as biomarkers for use in clinical investigations but diminished usefulness for epidemiologic studies.

  4. report that the recombinant PON1 (show PON1 Proteins)-hFc exerts hydrolytic activity against paraoxon and DFP (show PPCS Proteins).

  5. Results suggest that DNA methylation (show HELLS Proteins) may be an underlying mechanism explaining an adverse cardio-metabolic health profile in children carrying the PON1 (show PON1 Proteins) 192R-allele and prenatally exposed to pesticides.

  6. PON1 (show PON1 Proteins) L55M polymorphism might increase the risk of cancer [review; meta-analysis]

  7. This study shows an important interaction between PON1 (show PON1 Proteins) 192RR functional genotype and smoking. Smoking by PON1 (show PON1 Proteins) RR carriers was associated by significantly increased AIP (show AIP Proteins), triglyceride levels and a Framingham score risk and by significantly lower levels of HDL (show HSD11B1 Proteins) cholesterol. The findings provide an example of gene-environment interactions that increase cardiovascular risk.

  8. IgG anti-PON1 (show PON1 Proteins) antibodies are increased in rheumatoid arthritis patients compared with control.

  9. Data show that the mRNA levels of both paraoxonases PON2 (show PON2 Proteins) and PON3 (show PON3 Proteins) were significantly upregulated whereas PON1 (show PON1 Proteins)'s mRNA was absent in transgenic mouse hearts.

  10. The results of this study showed that in environmentally exposed Brazilian adults, low blood levels of lead, cadmium and mercury were not significantly associated with PON1 (show PON1 Proteins) activity and MDA concentrations. Considering the association with lead and cadmium levels, male sex, smoking and drinking habits influenced PON1 (show PON1 Proteins) activity, suggesting that these factors may confound the association with oxidative stress biomarkers.

Mouse (Murine) Flotillin 2 (FLOT2) interaction partners

  1. This study suggests that reggie-1 and reggie-2 (show FLOT1 Proteins) function at Rab11a (show RAB11A Proteins) recycling containers in the transport of PSD-95 (show DLG4 Proteins), N-cadherin (show CDH2 Proteins), GluA1 (show GRIA1 Proteins) and GluN1 (show GRIN1 Proteins), and promote (together with significant signaling molecules) spine-directed trafficking, spine synapse formation and the in vitro correlate of LTP (show SCP2 Proteins).

  2. These results indicated that miR (show MLXIP Proteins)-124 could potentially play a role in caveolin-independent vesicle trafficking and modulation of flotillin-2 expression in mouse acrosome biogenesis.

  3. The role of flotillin 1 (show FLOT1 Proteins) and flotillin 2 in regulating amyloid beta production in a mouse model of cerebral amyloidosis, remains unlear.

  4. Curcumin mediates neurite outgrowth through activation of the reggie-1 pathway.

  5. The genetic ablation of flotillin-2 in a mouse model or its knockdown in cultured cells increases extracellular signal regulated kinase (ERK (show EPHB2 Proteins)) activation.

  6. upregulation of reggie-1 in mammalian neurons provides nerve cells with neuron-intrinsic properties required for axon growth and successful regeneration

  7. flotillins have a role in NPC1L1 (show NPC1L1 Proteins)-mediated cholesterol uptake and NPC1L1 (show NPC1L1 Proteins)-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption

  8. Data suggest that the association between flotillin 1 (show FLOT1 Proteins)/2 microdomains and cortical cytoskeleton has important functions during neutrophil migration, in uropod formation, and in the regulation of myosin IIa.

  9. Reggie-1/flotillin-2 microdomains form independent of actin

  10. Lipid rafts were affected by both the dose and ratio of the beta-glycosphingolipids and the acyl chain length, and these effects were followed by downstream effects on STAT (show STAT1 Proteins) proteins.

Flotillin 2 (FLOT2) Protein Profile

Protein Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Gene names and symbols associated with Flotillin 2 Proteins (FLOT2)

  • Flotillin-2 (Flo-2)
  • flotillin 2 (flot2)
  • flotillin 2 (FLOT2)
  • flotillin 2 (Flot2)
  • flotillin 2-like (LOC100344093)
  • flotillin-2-like (LOC100856195)
  • flotillin-2-like (LOC100518752)
  • paraoxonase 1 (PON1)
  • AI573412 protein
  • CG11547 protein
  • CG14409 protein
  • CG32593 protein
  • Dmel\\CG32593 protein
  • DmFlo2 protein
  • ECS-1 protein
  • ECS1 protein
  • Esa protein
  • ESA1 protein
  • flo2 protein
  • FLOT2 protein
  • flotillin-2 protein
  • FLO[Dm]-2 protein
  • M17S1 protein
  • MVCD5 protein
  • PON protein
  • reggie-1 protein
  • reggie-2 protein

Protein level used designations for Flotillin 2 Proteins (FLOT2)

CG32593-PA , CG32593-PB , CG32593-PC , CG32593-PD , CG32593-PE , CG32593-PF , CG32593-PG , CG32593-PH , CG32593-PI , CG32593-PJ , CG32593-PK , CG32593-PL , Flo-2-PA , Flo-2-PB , Flo-2-PC , Flo-2-PD , Flo-2-PE , Flo-2-PF , Flo-2-PG , Flo-2-PH , Flo-2-PI , Flo-2-PJ , Flo-2-PK , Flo-2-PL , flotillin , flotillin 2 , flotillin-2 , flotillin2 , flottilin 2 , reggie-1 , reggie1 , flotillin-2-like , Flotillin 2 (epidermal surface antigen 1) , epidermal surface antigen , membrane component chromosome 17 surface marker 1 , membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1) , membrane component chromosome 17 surface marker 1 homolog , REG-1 , reggie1-1 , A-esterase 1 , K-45 , PON 1 , aromatic esterase 1 , arylesterase B-type , esterase A , paraoxonase B-type , serum aryldiakylphosphatase , serum aryldialkylphosphatase 1 , serum paraoxonase/arylesterase 1

GENE ID SPECIES
32425 Drosophila melanogaster
379990 Xenopus laevis
454537 Pan troglodytes
496443 Xenopus (Silurana) tropicalis
610963 Canis lupus familiaris
100072090 Equus caballus
100402699 Callithrix jacchus
100452158 Pongo abelii
100479641 Ailuropoda melanoleuca
100549413 Meleagris gallopavo
100580465 Nomascus leucogenys
2319 Homo sapiens
615679 Bos taurus
14252 Mus musculus
83764 Rattus norvegicus
417579 Gallus gallus
100721332 Cavia porcellus
100344093 Oryctolagus cuniculus
100856195 Canis lupus familiaris
100518752 Sus scrofa
5444 Homo sapiens
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