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FOXD3 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Additionally we are shipping FOXD3 Antibodies (84) and FOXD3 Kits (12) and many more products for this protein.
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Foxd3 rescues the prdm1a (show PRDM1 Proteins) loss-of-function neural crest phenotype.
These results reveal dynamic and differential regulation of FoxD3 in distinct neural crest subpopulations, suggesting that heterogeneity is encrypted at the regulatory level
analysis of how a FoxD3 gene trap line reveals neural crest precursor movement and a role for FoxD3 in their specification
tfap2a (show TFAP2A Proteins) and foxd3 are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a (show TFAP2A Proteins) is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and ectoderm
analysis of a Foxd3/mitfa (show MITF Proteins) transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate
foxd3 is an essential Nodal-dependent regulator of zebrafish mesoderm development.
Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.
zebrafish Foxd3 is necessary for the differentiation of a subset of neural crest cell fates, perhaps in precursors of particular neural crest lineages.
Foxd3, a well-known regulator in neural crest development, is also involved in myf5 (show MYF5 Proteins) regulation
Foxd3 selectively specifies premigratory neural crest cells for a neuronal, glial or cartilage fate by inducing the expression of lineage-associated transcription factors in these cells and regulating their subsequent migration.
FOXD3/miR (show MLXIP Proteins)-214/MED19 (show MED19 Proteins) axis is important for the regulation of growth, invasion and metastasis of colorectal cancer
total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction.Methylation of those aforementioned genes in white blood cells of our young patients may highlight their potential as early epimarkers
Results showed that silencing FoxD3 in lung cancer cell lines stimulated cell growth and inhibited cell apoptosis.
FOXD3 is sufficient but not necessary to drive PAX3 (show PAX3 Proteins) expression in melanoma cells.
The present study finds that the aspirin-FOXD3-OLA1P2-STAT3 (show STAT3 Proteins) axis exhibits exciting anticancer effects and provides new insights into the chemopreventive mechanisms underlying aspirin use
FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for high-grade gliomas, which warrant further investigation.
Down-regulation of FOXD3 is associated with metastasis in hepatocellular carcinoma.
Data show that transcription factors PAX3 (show PAX3 Proteins) and FOXD3-mediated melanoma cell migration is dependent on promoting the expression of chemokine receptor CXCR4 (show CXCR4 Proteins).
In addition to a possible association of rs78645479 in FoxD3 with vitiligo (show MITF Proteins), our data on the association of this FoxD3 variant with thyroid autoantibodies suggest a potential involvement of FoxD3 in thyroid immunoregulation.
FOXD3 overexpression significantly inhibits cell growth and results in G1 cell cycle arrest in NSCLC A549 and H1299 cells.
FOXD3-AS1 (show ARSB Proteins) serves as a sponge or as a competing endogenous noncoding RNA for miR (show MLXIP Proteins)-150, restricting its capability to promote cell growth and thereby exaggerating hyperoxia-induced lung epithelial cell death
suggest that CHD7 (show CHD3 Proteins), Oct3/4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), and Nanog (show NANOG Proteins) directly induce FoxD3 expression when stimulated by BMP2 (show BMP2 Proteins)/Wnt3a (show WNT3A Proteins) signaling, that FoxD3 promotes Sox10 (show SOX10 Proteins) expression, and that histone H3K4 methylation play important roles in this process of neural crest-derived stem cell formation
this study shows that Foxd3 suppresses the production of IL-10 (show IL10 Proteins)+ Breg cells by directly binding the IL-10 (show IL10 Proteins) promoter
Foxd3 poises enhancers in pluripotent stem cells by recruiting multiple epigenetic enzymes that together simultaneously initiate and repress enhancer activity.
analysis of a cycle of activation and deactivation of Foxd3 required for exit from naive pluripotency and subsequent primordial germ cell specification
Foxd3 suppresses NFAT (show NFATC1 Proteins)-mediated differentiation to maintain self-renewal of embryonic stem cells
In a xenograft tumor model, FOXD3 overexpression inhibits tumor growth and angiogenesis.
Data indicate that homeobox b5 (Hoxb5 (show HOXB5 Proteins)) regulated the neural crest (NC)development by directly inducing Forkhead box D3 gene (Foxd3).
Foxd3 induced mutant ESCs (show NR2E3 Proteins) precociously express genes required for mesoderm induction, but they are likely unable to differentiate into skeletal muscle.
Data indicate that growth factor receptor (show RYK Proteins) protein binding protein 2 (Grb2 (show GRB2 Proteins)) is upregulated and regulated by Forkhead Box D3 (Foxd3), and pregulated Grb2 (show GRB2 Proteins) interacts with huntingtin (Htt (show HTT Proteins)).
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.
fork head domain protein 6
, forkhead box protein D3
, mother superior
, forkhead box D3
, HNF3/FH transcription factor genesis
, HNF-3/forkhead homolog 2
, hepatocyte nuclear factor 3 forkhead homolog 2
, winged helix protein CWH-3
, winged-helix protein CWH-3