Forkhead Box D3 Proteins (FOXD3)

FOXD3 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Additionally we are shipping FOXD3 Antibodies (84) and FOXD3 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXD3 27022 Q9UJU5
FOXD3 15221 Q61060
Rat FOXD3 FOXD3 29203  
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Top FOXD3 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days

FOXD3 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for Forkhead Box D3 (FOXD3) Interaction Partners

Zebrafish Forkhead Box D3 (FOXD3) interaction partners

  1. Foxd3 rescues the prdm1a (show PRDM1 Proteins) loss-of-function neural crest phenotype.

  2. These results reveal dynamic and differential regulation of FoxD3 in distinct neural crest subpopulations, suggesting that heterogeneity is encrypted at the regulatory level

  3. analysis of how a FoxD3 gene trap line reveals neural crest precursor movement and a role for FoxD3 in their specification

  4. tfap2a (show TFAP2A Proteins) and foxd3 are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a (show TFAP2A Proteins) is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and ectoderm

  5. analysis of a Foxd3/mitfa (show MITF Proteins) transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate

  6. foxd3 is an essential Nodal-dependent regulator of zebrafish mesoderm development.

  7. Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.

  8. zebrafish Foxd3 is necessary for the differentiation of a subset of neural crest cell fates, perhaps in precursors of particular neural crest lineages.

  9. Foxd3, a well-known regulator in neural crest development, is also involved in myf5 (show MYF5 Proteins) regulation

  10. Foxd3 selectively specifies premigratory neural crest cells for a neuronal, glial or cartilage fate by inducing the expression of lineage-associated transcription factors in these cells and regulating their subsequent migration.

Human Forkhead Box D3 (FOXD3) interaction partners

  1. FOXD3/miR (show MLXIP Proteins)-214/MED19 (show MED19 Proteins) axis is important for the regulation of growth, invasion and metastasis of colorectal cancer

  2. total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction.Methylation of those aforementioned genes in white blood cells of our young patients may highlight their potential as early epimarkers

  3. Results showed that silencing FoxD3 in lung cancer cell lines stimulated cell growth and inhibited cell apoptosis.

  4. FOXD3 is sufficient but not necessary to drive PAX3 (show PAX3 Proteins) expression in melanoma cells.

  5. The present study finds that the aspirin-FOXD3-OLA1P2-STAT3 (show STAT3 Proteins) axis exhibits exciting anticancer effects and provides new insights into the chemopreventive mechanisms underlying aspirin use

  6. FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for high-grade gliomas, which warrant further investigation.

  7. Down-regulation of FOXD3 is associated with metastasis in hepatocellular carcinoma.

  8. Data show that transcription factors PAX3 (show PAX3 Proteins) and FOXD3-mediated melanoma cell migration is dependent on promoting the expression of chemokine receptor CXCR4 (show CXCR4 Proteins).

  9. In addition to a possible association of rs78645479 in FoxD3 with vitiligo (show MITF Proteins), our data on the association of this FoxD3 variant with thyroid autoantibodies suggest a potential involvement of FoxD3 in thyroid immunoregulation.

  10. FOXD3 overexpression significantly inhibits cell growth and results in G1 cell cycle arrest in NSCLC A549 and H1299 cells.

Mouse (Murine) Forkhead Box D3 (FOXD3) interaction partners

  1. FOXD3-AS1 (show ARSB Proteins) serves as a sponge or as a competing endogenous noncoding RNA for miR (show MLXIP Proteins)-150, restricting its capability to promote cell growth and thereby exaggerating hyperoxia-induced lung epithelial cell death

  2. suggest that CHD7 (show CHD3 Proteins), Oct3/4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), and Nanog (show NANOG Proteins) directly induce FoxD3 expression when stimulated by BMP2 (show BMP2 Proteins)/Wnt3a (show WNT3A Proteins) signaling, that FoxD3 promotes Sox10 (show SOX10 Proteins) expression, and that histone H3K4 methylation play important roles in this process of neural crest-derived stem cell formation

  3. this study shows that Foxd3 suppresses the production of IL-10 (show IL10 Proteins)+ Breg cells by directly binding the IL-10 (show IL10 Proteins) promoter

  4. Foxd3 poises enhancers in pluripotent stem cells by recruiting multiple epigenetic enzymes that together simultaneously initiate and repress enhancer activity.

  5. analysis of a cycle of activation and deactivation of Foxd3 required for exit from naive pluripotency and subsequent primordial germ cell specification

  6. Foxd3 suppresses NFAT (show NFATC1 Proteins)-mediated differentiation to maintain self-renewal of embryonic stem cells

  7. In a xenograft tumor model, FOXD3 overexpression inhibits tumor growth and angiogenesis.

  8. Data indicate that homeobox b5 (Hoxb5 (show HOXB5 Proteins)) regulated the neural crest (NC)development by directly inducing Forkhead box D3 gene (Foxd3).

  9. Foxd3 induced mutant ESCs (show NR2E3 Proteins) precociously express genes required for mesoderm induction, but they are likely unable to differentiate into skeletal muscle.

  10. Data indicate that growth factor receptor (show RYK Proteins) protein binding protein 2 (Grb2 (show GRB2 Proteins)) is upregulated and regulated by Forkhead Box D3 (Foxd3), and pregulated Grb2 (show GRB2 Proteins) interacts with huntingtin (Htt (show HTT Proteins)).

FOXD3 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.

Gene names and symbols associated with Forkhead Box D3 Proteins (FOXD3)

  • forkhead box D3 (foxd3)
  • forkhead box D3 (FOXD3)
  • forkhead box D3 (LOC100301607)
  • forkhead box D3 (Foxd3)
  • AIS1 protein
  • CWH3 protein
  • fkd6 protein
  • fkh6 protein
  • forkhead-6 protein
  • FOXD3 protein
  • Genesis protein
  • Hfh2 protein
  • VAMAS2 protein
  • XFD-6 protein
  • xfoxd3 protein
  • zgc:111934 protein

Protein level used designations for Forkhead Box D3 Proteins (FOXD3)

fork head domain protein 6 , forkhead box protein D3 , mother superior , forkhead box D3 , HNF3/FH transcription factor genesis , HFH-2 , HNF-3/forkhead homolog 2 , hepatocyte nuclear factor 3 forkhead homolog 2 , winged helix protein CWH-3 , winged-helix protein CWH-3

30548 Danio rerio
456905 Pan troglodytes
496851 Xenopus (Silurana) tropicalis
696085 Macaca mulatta
100301607 Oryzias latipes
27022 Homo sapiens
489558 Canis lupus familiaris
532383 Bos taurus
15221 Mus musculus
29203 Rattus norvegicus
395794 Gallus gallus
101102030 Ovis aries
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