Forkhead Box E3 Proteins (FOXE3)

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. Additionally we are shipping FOXE3 Antibodies (59) and FOXE3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXE3 2301 Q13461
FOXE3 30923 Q9QY14
Rat FOXE3 FOXE3 171302  
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Top FOXE3 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days

FOXE3 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for Forkhead Box E3 (FOXE3) Interaction Partners

Zebrafish Forkhead Box E3 (FOXE3) interaction partners

  1. Data demonstrate that Foxe3 is necessary for lens development in zebrafish and that foxe3 lies genetically downstream of pitx3 (show PITX3 Proteins) in a zebrafish lens development pathway.

  2. foxe3 function is necessary for the execution of lens-specific gene expression and lens morphogenesis.

Human Forkhead Box E3 (FOXE3) interaction partners

  1. FOXE3 mutations lead to a reduced number of aortic smooth muscle cells (SMCs) during development and increased SMC (show DYM Proteins) apoptosis in the ascending aorta in response to increased biomechanical forces.

  2. This is the first functional evidence demonstrating that FOXE3 mutations identified in patients impair protein function with differential effects.

  3. Our results indicate that the FOXE3 p.Val201Met allele is associated with eye defects (OR = 3.5), suggesting its involvement as an ocular malformation risk factor.

  4. This study demonstrates that a cluster of patients with sclerocornea, aphakia (show PITX3 Proteins), and microphthalmia in a small Mexican village is due to a FOXE3 p.Y98H founder mutation.

  5. shRNA-mediated gene silencing of FOXE3 could significantly inhibit cell growth and induce the G1-phase arrest in human lens epithelial cell line-3 cells.

  6. The FOXE3 mutation detected in c.601 G > A, predicting p.Val201Met which were not yet been included in public databases, but has previously been reported in both A/M patients.

  7. Autosomal-dominant mutations within FOXE3 cause anterior segment dysgenesis and has important clinical utility, especially for the diagnosis of mildly affected patients.

  8. Using autoantibodies from systemic sclerosis (SSc (show CYP11A1 Proteins)) patients, two anti-CENP-A (show CENPA Proteins)-specific motifs were defined in its immunodominant epitope Ap17 (show AP2S1 Proteins)-30. One of these motifs matched residues 53-62 of FOXE3, a protein not previously implicated in SSc (show CYP11A1 Proteins).

  9. This is the fourth report detailing homozygous FOXE3 mutations causing anterior segment abnormalities in human patients.

  10. Mutations in several transcription factors associated with aniridia and congenital cataract, FOXE3, (PAX6 (show PAX6 Proteins)), PITX2 (show PITX2 Proteins), and PITX3 (show PITX3 Proteins) genes, were examined.

Mouse (Murine) Forkhead Box E3 (FOXE3) interaction partners

  1. The Hedgehog (show SHH Proteins) pathway with its member Smoothened is required during a discrete embryonic period (E9.5-E12.5) in lens development to regulate lens epithelial cell proliferation, survival and FoxE3 expression.

  2. Foxe3 as a transcriptional target of Pitx3 (show PITX3 Proteins) explains at least in part some of the phenotypic similarities of the ak and dyl mice (dysgenic lens, a Foxe3 allele).

  3. The observed changes in the expression of FoxE3 suggest that Msx2 is an important contributor in controlling transcription of target genes critical for early eye development.

  4. the ectopic activation of downstream effectors of the hedgehog (show SHH Proteins) signaling pathway in the mouse lens disrupts normal fiber cell differentiation by a mechanism consistent with a sustained epithelial cellular developmental program driven by FoxE3.

  5. cataracts in rct mice are caused by reduced Foxe3 expression in the lens and this decreased expression is a result of a deletion in a cis (show CISH Proteins)-acting regulatory element

  6. Foxe3 promoter was activated by Sip1

  7. targeted disruption of Foxe3 results in abnormal development of the eye. Cells of the anterior lens epithelium show a decreased rate of proliferation, resulting in a smaller than normal lens.

  8. early Foxe3 expression is sensitive to halved Pax6 (show PAX6 Proteins) gene dosage & there is phenotypic similarity between Pax6 (show PAX6 Proteins) & Foxe3 mutants; we propose that many ocular malformations associated with Pax6 (show PAX6 Proteins) haploinsufficiency are consequences of reduced Foxe3 expression

  9. Proper inactivation of FoxE3 expression at the lens equator is important for many aspects of fiber differentiation, and persistent expression leads to a partial epithelialization of fiber cells, with severe consequences for lens function.

  10. Data found no evidence that Pitx3 (show PITX3 Proteins) and Foxe3 genetically interact.

FOXE3 Protein Profile

Protein Summary

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia.

Gene names and symbols associated with Forkhead Box E3 Proteins (FOXE3)

  • forkhead box E3 (foxe3)
  • forkhead box E3 (FOXE3)
  • forkhead box E3 (LOC100301611)
  • forkhead box E3 (Foxe3)
  • dyl protein
  • FKHL12 protein
  • FOXE3 protein
  • foxe4 protein
  • FREAC-8 protein
  • FREAC8 protein
  • HFH7 protein
  • HNF3 protein
  • lens1 protein
  • lens1-A protein
  • rct protein

Protein level used designations for Forkhead Box E3 Proteins (FOXE3)

forkhead box protein E3 , forkhead box E3 , FREAC-8 , forkhead, drosophila, homolog-like 12 , forkhead-related protein FKHL12 , forkhead-related transcription factor 8 , Rinshoken cataract , dysgenetic lens , hepatocyte nuclear factor 3 forkhead homolog 7 , forkhead box protein E4 , forkhead protein lens1 , xlens1

570855 Danio rerio
772006 Gallus gallus
100301611 Oryzias latipes
2301 Homo sapiens
30923 Mus musculus
171302 Rattus norvegicus
373809 Xenopus laevis
610277 Canis lupus familiaris
787258 Bos taurus
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