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The protein encoded by FNBP1L binds to both CDC42 and N-WASP. Additionally we are shipping FNBP1L Antibodies (61) and FNBP1L Kits (3) and many more products for this protein.
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Loss of p53 tumor suppressor (show TP53 Proteins) function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease.
GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence
findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma
Toca-1 knockdown cells also display a significant defect in EGF (show EGF Proteins)-induced motility and invasiveness.
Cdc42 (show CDC42 Proteins) may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP (show WASL Proteins) complex.
Toca-1 promotes actin nucleation by activating the N-WASP (show WASL Proteins)-WIP/CR16 complex, the predominant form of N-WASP (show WASL Proteins) in cells.
a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP (show WASL Proteins)
We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP (show WASL Proteins) from a closed inactive conformation to an open active one.
the Toca-1-N-WASP (show WASL Proteins) complex can link filopodial formation to endocytosis
Human FNBP1L binds the autophagy protein Atg3 (show ATG3 Proteins) and is required for autophagy of Salmonella Typhimurium in epithelial cells
Toca-1(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP (show WASL Proteins).
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
formin binding protein 1-like
, formin-binding protein 1-like
, transducer of Cdc42-dependent actin assembly-1
, transducer of Cdc42-dependent actin assembly 1
, transducer of Cdc42-dependent actin assembly protein 1
, Cdc42 effector