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Formin Binding Protein 1-Like Proteins (FNBP1L)

The protein encoded by FNBP1L binds to both CDC42 and N-WASP. Additionally we are shipping FNBP1L Antibodies (57) and FNBP1L Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FNBP1L 54874 Q5T0N5
FNBP1L 214459 Q8K012
FNBP1L 310839 Q2HWF0
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Top FNBP1L Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

FNBP1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Formin Binding Protein 1-Like (FNBP1L) Interaction Partners

Human Formin Binding Protein 1-Like (FNBP1L) interaction partners

  1. Loss of p53 tumor suppressor (show TP53 Proteins) function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease.

  2. GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence

  3. findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma

  4. Toca-1 knockdown cells also display a significant defect in EGF (show EGF Proteins)-induced motility and invasiveness.

  5. Cdc42 (show CDC42 Proteins) may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP (show WASL Proteins) complex.

  6. Toca-1 promotes actin nucleation by activating the N-WASP (show WASL Proteins)-WIP/CR16 complex, the predominant form of N-WASP (show WASL Proteins) in cells.

  7. a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP (show WASL Proteins)

  8. We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP (show WASL Proteins) from a closed inactive conformation to an open active one.

  9. the Toca-1-N-WASP (show WASL Proteins) complex can link filopodial formation to endocytosis

  10. Human FNBP1L binds the autophagy protein Atg3 (show ATG3 Proteins) and is required for autophagy of Salmonella Typhimurium in epithelial cells

Mouse (Murine) Formin Binding Protein 1-Like (FNBP1L) interaction partners

  1. Toca-1(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP (show WASL Proteins).

FNBP1L Protein Profile

Protein Summary

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with FNBP1L

  • formin binding protein 1-like (FNBP1L)
  • formin binding protein 1-like (fnbp1l)
  • formin binding protein 1-like (Fnbp1l)
  • formin-binding protein 1-like (LOC100909995)
  • 2610318I01Rik protein
  • AW548221 protein
  • C1orf39 protein
  • MGC132162 protein
  • RGD1305386 protein
  • toca-1 protein
  • TOCA1 protein
  • zgc:100923 protein

Protein level used designations for FNBP1L

formin binding protein 1-like , formin-binding protein 1-like , transducer of Cdc42-dependent actin assembly-1 , toca-1 , transducer of Cdc42-dependent actin assembly 1 , transducer of Cdc42-dependent actin assembly protein 1 , Cdc42 effector

424495 Gallus gallus
445240 Danio rerio
448740 Xenopus (Silurana) tropicalis
469385 Pan troglodytes
479942 Canis lupus familiaris
616665 Bos taurus
713578 Macaca mulatta
735241 Xenopus laevis
100032840 Monodelphis domestica
100059052 Equus caballus
100077332 Ornithorhynchus anatinus
100157977 Sus scrofa
100338578 Oryctolagus cuniculus
100405015 Callithrix jacchus
100448000 Pongo abelii
100476131 Ailuropoda melanoleuca
100559983 Anolis carolinensis
54874 Homo sapiens
214459 Mus musculus
310839 Rattus norvegicus
100909995 Rattus norvegicus
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