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Glucose 6-Phosphatase, Catalytic Proteins (G6PC)

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. Additionally we are shipping G6PC Antibodies (23) and G6PC Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
G6PC 14377 P35576
G6PC 2538 P35575
Rat G6PC G6PC 25634 P43428
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Top G6PC Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

G6PC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Glucose 6-Phosphatase, Catalytic (G6PC) Interaction Partners

Mouse (Murine) Glucose 6-Phosphatase, Catalytic (G6PC) interaction partners

  1. We conclude that G6PD (show G6PD Proteins) deficiency at the level of the animals in the present study may not be a risk factor for developing CSN-OT, but this remains to be verified for human subjects

  2. The results strongly suggested that the increase of glucagon (show GCG Proteins) levels could account for the induction of G6pc expression in the kidneys and intestine of L-G6pc-/- mice.

  3. PPARalpha (show PPARA Proteins) is responsible for glucose production through the up-regulation of hepatic G6Pase gene expression during fasting or type 2 diabetes animal models

  4. gene transcription in H4IIE cells mediated by hepatocyte nuclear factor-4 alpha's stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha

  5. Evidence for the expression of the catalytic domain of hepatic glucose-6-phosphatase in pancreatic islets.

  6. Loss of G6pt activity causes neutropenia, and local production of the chemokines KC and macrophage inflammatory protein-2 (show CXCL2 Proteins) are defective in G6pt-/- neutrophils.

  7. G6pc expression was functionally silenced by adenovirus-mediated delivery of short hairpin RNA.

  8. muscle expresses both Glc-6-Pase-beta and Glc-6-P transporter and that they can couple to form an active Glc-6-Pase complex

  9. Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production.

  10. Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 (show SLC2A2 Proteins) and glucose 6-phosphatase

Human Glucose 6-Phosphatase, Catalytic (G6PC) interaction partners

  1. ApoA-IV (show APOA4 Proteins) colocalizes with NR4A1 (show NR4A1 Proteins), which suppresses G6Pase and PEPCK (show PEPCK Proteins) gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose.

  2. By direct DNA sequencing, three novel G6PC variations were identified which expanded the G6PC mutation spectrum, and provided conclusive genetic evidences for the definitive diagnosis of the Chinese patients.

  3. This study is the first to demonstrate a functional relationship between the critical gluconeogenic and glycogenolytic enzyme G6PC with the metabolic adaptations during glioblastoma invasion.

  4. The spectrum of mutations in the G6PC gene.

  5. Lipopolysaccharide and monophosphoryl lipid A also up-regulated G6PC and PCK1 (show PCK1 Proteins) transcript abundance in a TLR4 (show TLR4 Proteins)-dependent manner.

  6. LSD1 (show KDM1A Proteins) regulates transcription activation of two gluconeogenic genes, FBP1 (show FBP1 Proteins) and G6Pase.

  7. Both GSD-1a and G6PT strongly colocalised in perinuclear membranes. showed that GSD1 mutations did neither alter the G6PC or G6PT chimera localisation, nor the interaction between G6PT termini.

  8. results reveal a novel link between glucose metabolism and the DNA damage signaling pathway and suggest a possible role for PEPCK and G6P in the DNA damage response

  9. data mitigate against G6PD (show G6PD Proteins) deficiency contributing to stroke risk in individuals with sickle cell anemia.

  10. description of G6PC mutations in Thailand patients with glycogen (show GYS1 Proteins) storage disease type Ia

G6PC Protein Profile

Protein Summary

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.

Gene names and symbols associated with G6PC

  • glucose-6-phosphatase, catalytic (G6pc)
  • glucose-6-phosphatase, catalytic subunit (G6PC)
  • glucose-6-phosphatase, catalytic subunit (G6pc)
  • AW107337 protein
  • G-6-Pase protein
  • G6Pase protein
  • G6PC1 protein
  • G6PT protein
  • Glc-6-Pase protein
  • GSD1 protein
  • GSD1a protein

Protein level used designations for G6PC

G-6-Pase , Glc-6-Pase-alpha , glucose-6-phosphatase , G6Pase , G6Pase-alpha , glucose-6-phosphatase alpha , glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) , glucose-6-phosphatase catalytic subunit

GENE ID SPECIES
14377 Mus musculus
2538 Homo sapiens
403492 Canis lupus familiaris
100134959 Sus scrofa
538710 Bos taurus
25634 Rattus norvegicus
723970 Felis catus
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