Glutamate Receptor, Metabotropic 6 Proteins (GRM6)

has adenylate cyclase inhibiting metabotropic glutamate receptor activity\; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina [RGD, Feb 2006].. Additionally we are shipping Metabotropic Glutamate Receptor 6 Antibodies (102) and Metabotropic Glutamate Receptor 6 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRM6 2916 O15303
GRM6 108072 Q5NCH9
Rat GRM6 GRM6 24419 P35349
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Top Metabotropic Glutamate Receptor 6 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

GRM6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Glutamate Receptor, Metabotropic 6 (GRM6) Interaction Partners

Human Glutamate Receptor, Metabotropic 6 (GRM6) interaction partners

  1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated.

  2. Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness.

  3. These data suggest differences in coupling of TRPM1 (show TRPM1 Proteins) function to mGluR6 signaling explain different cellular responses to glutamate (show GRIN1 Proteins) in the retina and the skin.

  4. We found 5 different mutations in GRM6, in congenital stationary night blindness.

  5. The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina.

  6. The results expand the mutation spectrum of NYX (show NYX Proteins), CACNA1F (show CACNA1F Proteins) and GRM6. They also suggest that NYX (show NYX Proteins) mutations are a common cause of congenital stationary night blindness (CSNB (show CSN2 Proteins)).

  7. The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction.

  8. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6.

  9. Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6.

  10. The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate (show GRIN1 Proteins) receptors to the cell surface.

Mouse (Murine) Glutamate Receptor, Metabotropic 6 (GRM6) interaction partners

  1. These results indicate that Grm6 nob7 is a new model of the complete form of congenital stationary night blindness.

  2. The mGluR6-KO phenotype showed negative effects on ribbon synapse formation.

  3. Diagnosis of concurrent Stargardt disease and CSNB (show CSN2 Proteins) was made on the ophthalmic history; genetic testing revealed two previously reported mutations in the ABCA4 (show ABCA4 Proteins) gene and two novel deletions in the GRM6 gene.

  4. the localization and stability of Cacna1s (show CACNA1S Proteins) depend on the expression of mGluR6 and its cascade components, and they suggest that Cacna1s (show CACNA1S Proteins) is part of the mGluR6 complex.

  5. The results suggested that the TRPM1 (show TRPM1 Proteins) channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized.

  6. These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs.

  7. The mGluR6 mRNA levels are altered in the young and adult rat retina of Royal College of Surgeons rat and suggest that the genetically induced degeneration of photoreceptors affects the expression of this receptor by the INL retinal neurons.

  8. In mGluR6-null mice, long-latency ON responses are observed in the visual cortex, indicating that they can be conducted reliably to higher visual areas.

  9. mGluR6 expression was limited to the outer plexiform layer

  10. Visual responses of Grm6(no b-wave3 (show WASF3 Proteins)) retinal ganglion cells to light onset were abnormal.

Metabotropic Glutamate Receptor 6 (GRM6) Protein Profile

Protein Summary

has adenylate cyclase inhibiting metabotropic glutamate receptor activity\; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina

Gene names and symbols associated with GRM6

  • glutamate receptor, metabotropic 6 (GRM6)
  • metabotropic glutamate receptor 6 (MGLUR6)
  • glutamate receptor, metabotropic 6 (Grm6)
  • glutamate receptor, metabotropic 6a (grm6a)
  • BC021919 protein
  • CSNB1B protein
  • Gm3 protein
  • Gprc1f protein
  • GRM6 protein
  • mGlu6 protein
  • mGluR6 protein
  • nerg1 protein
  • nob2 protein
  • nob3 protein
  • nob4 protein
  • si:dkey-52h10.3 protein

Protein level used designations for GRM6

metabotropic glutamate receptor 6 , G protein-coupled receptor GRM6 , G protein-coupled receptor, family C, group 1, member F , grm6 , mglur6a

462323 Pan troglodytes
443292 Ovis aries
2916 Homo sapiens
108072 Mus musculus
24419 Rattus norvegicus
481452 Canis lupus familiaris
568484 Danio rerio
100009501 Oryctolagus cuniculus
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