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L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping GRM7 Antibodies (97) and GRM7 Proteins (7) and many more products for this protein.
Showing 5 out of 18 products:
results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population.
results reported here do not support a role for GRM7 in ADHD
Copy number variants at GRM7 may have a role in the etiology of bipolar disorder.
For neither PCLO (show PCLO ELISA Kits) nor GRM7 we found a more associated variant. For SLC6A4 (show SLC6A4 ELISA Kits), we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS
in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns.
These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population
Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults.
Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population.
Data sets demonstrated a region of association for major depressive disorder within GRM7. Thus, the significance of this finding remains uncertain.
we were unable to detect SUMOylation of full-length mGluR7 in either heterologous cells or neurons
muscle does not appear to require high levels of SMN (show STMN1 ELISA Kits) above what is produced by two copies of SMN2 (show SMN1 ELISA Kits)
SAM68 (show KHDRBS1 ELISA Kits) is a physiological regulator of SMN2 (show SMN1 ELISA Kits) splicing in a spinal muscular atrophy mouse model.
Hyperoxia treatment increased the inclusion of SMN2 (show SMN1 ELISA Kits) exon 7 in skeletal muscles and resulted in improved motor function.
Elfn1 recruits mGluR7 (show GRM2 ELISA Kits) to synaptic sites.A trans interaction of Elfn1 and mGluR7 (show GRM2 ELISA Kits) controls targeted interneuron synapse development.
GRM7 regulates the phosphorylation of CREB (show CREB1 ELISA Kits) protein and the expression of Yes-associated protein (YAP (show YAP1 ELISA Kits)) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development.
Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design
The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression
These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders.
Glutamate (show GRIN1 ELISA Kits) release mediated by GluR7 (show GRIK3 ELISA Kits) at nerve terminals is influenced by divalent calcium channel type Ca2 (show CA2 ELISA Kits)+ ionophore.
mGluR7 (show GRM2 ELISA Kits), by affecting the cofilin (show CFL1 ELISA Kits)/actin signaling, regulates NMDAR (show GRIN1 ELISA Kits) trafficking and function
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
metabotropic glutamate receptor 7
, G protein-coupled receptor GRM7
, G protein-coupled receptor, family C, group 1, member G
, mGlu7a receptor
, metabotropic glutamate receptor mGluR7
, metabotropic glutamate receptor subtype 7b