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Glutaminase Proteins (GLS)

GLS encodes the K-type mitochondrial glutaminase. Additionally we are shipping Glutaminase Antibodies (80) and Glutaminase Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLS 14660 D3Z7P3
GLS 2744 O94925
GLS 24398 P13264
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Top Glutaminase Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 11 to 13 Days

GLS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , ,
, ,
Rat (Rattus)

More Proteins for Glutaminase (GLS) Interaction Partners

Mouse (Murine) Glutaminase (GLS) interaction partners

  1. findings suggest that glutaminase Heterozygote mice have a pro-cognitive profile in the trace fear conditioning paradigm, and this phenotype involves activation of both hippocampus and Anterior Cingulate Cortex.

  2. studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.

  3. The Phosphate-Activated Glutaminase (show GLS2 Proteins)(PAG (show PRDX1 Proteins)) is mainly active in mouse kidney, brain and liver, and shows different kinetics depending on which type of PAG (show PRDX1 Proteins) is expressed.

  4. The network identified in glutaminase deficient fetal mouse brain involves (a) cellular assembly and organization and (b) cell signaling and cell cycle, suggesting that Gls is crucial for neuronal maturation.

  5. kidney-type glutaminase (KGA) as a novel partner of Bmcc1s

  6. The up-regulation of neuronal glutaminase was demonstrated in situ in a murine model of HIV-1 encephalitis.

  7. identified a novel distant regulatory element located approximately 120kb downstream of the gls promoter, and examined its regulatory relevance to gls gene expression in C2C12 cells

  8. Study demonstrated expression of alternative transcripts of the mammalian Gls2 (show GLS2 Proteins) gene. Transcriptional mechanisms giving rise to GLS2 (show GLS2 Proteins) variants and isolation of novel GLS2 (show GLS2 Proteins) transcripts in human, rat and mouse are presented.

  9. In wild-type (WT) mice, GLS1 gene expression was highest in the hippocampus and cortex, where it was reduced by about 50% in Glutaminase-deficient mice.

  10. Phosphate-activated glutaminase (GLS2 (show GLS2 Proteins)) is a p53 (show TP53 Proteins)-inducible regulator of glutamine (show GFPT1 Proteins) metabolism and reactive oxygen species

Fruit Fly (Drosophila melanogaster) Glutaminase (GLS) interaction partners

  1. The memory deficits observed in nemy are because of reduced function of CytB561 (show CYB561 Proteins) in specific brain regions that are involved in learning and memory.

Human Glutaminase (GLS) interaction partners

  1. Glutaminase expression in tumor cells was significantly associated with a low level of tumor-infiltrating lymphocytesand poor disease-free survival in triple-negative breast cancers presenting with lymph node metastasis and high levels of tumor-infiltrating lymphocytes.

  2. Study reports that GLS1 is a direct target of miR (show MLXIP Proteins)-23a in retinal pigment epithelium cells (RPE (show RPE Proteins)) providing evidence for a role in maintaining RPE (show RPE Proteins) cell function.

  3. The relative expression of microRNA-153 and glutaminase in glioblastoma versus matched non-tumor tissues showed a reverse correlation, further indicating that microRNA-153 may negatively regulate glutaminase in vivo.

  4. High GLS1 expression is associated with epithelial-mesenchymal transition in cancer.

  5. Data suggest that glutaminase C (GAC) inhibition maybe a potential treatment strategy for acquired erlotinib-resistant non-small cell lung cancer (NSCLC).

  6. Findings indicate a role for transcription factor c-Jun (show JUN Proteins) as a driver of cancer cell metabolic reprogramming, and suggest that cancers overexpressing JUN (show JUN Proteins) may be especially sensitive to glutaminase (GLS)-targeted therapies.

  7. GLS1 was identified as a potential downstream target of the miR (show MLXIP Proteins)-192/-204-HOTTIP axis in hepatocellular carcinoma.

  8. In the present study it was determined whether three key enzymes for glycolysis, glutaminolysis and de novo synthesis of FAs (show FAS Proteins), hexokinase-2 (show HK2 Proteins), glutaminase and fatty acid synthase (show FASN Proteins)

  9. Our findings support the role of the GLS long microsatellite in the development of HE; this could be important for identifying susceptible patients and for the prevention of this condition.

  10. GABAergic neurons and astrocytes express Gls and Gls2 (show GLS2 Proteins) isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons

Glutaminase (GLS) Protein Profile

Protein Summary

This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Glutaminase Proteins (GLS)

  • glutaminase (GLS)
  • glutaminase (Gls)
  • glutaminase (gls)
  • glutaminase b (glsb)
  • CG42708 gene product from transcript CG42708-RA (CG42708)
  • hypothetical protein (glutaminase)
  • glutaminase (glsA-2)
  • glutaminase (Arnit_3113)
  • glutaminase (Celal_2913)
  • Glutaminase (Odosp_0379)
  • Glutaminase (Odosp_1505)
  • Glutaminase (Celly_0289)
  • glutaminase (Weevi_2101)
  • glutaminase (Mesop_4683)
  • glutaminase 2 (liver, mitochondrial) (Gls2)
  • 6330442B14 protein
  • A330074B06Rik protein
  • AAD20 protein
  • AI195532 protein
  • AI314027 protein
  • B230365M23Rik protein
  • BA3155 protein
  • CG8772 protein
  • CG8872 protein
  • Dmel\\CG42708 protein
  • Dmel_CG8772 protein
  • GA protein
  • GAC protein
  • GAM protein
  • GLS protein
  • GLS1 protein
  • Glut protein
  • KGA protein
  • Lga protein
  • PAG protein
  • RATGLUT protein
  • si:dz87i4.2 protein
  • wu:fa97e05 protein

Protein level used designations for Glutaminase Proteins (GLS)

glutaminase kidney isoform, mitochondrial , phosphate-activated glutaminase , glutaminase C , glutaminase , CG42708-PA , CG42708-PB , CG42708-PC , CG42708-PD , CG42708-PE , CG42708-PF , CG42708-PH , CG42708-PI , hypothetical protein , Glutaminase , K-glutaminase , L-glutamine amidohydrolase , glutaminase, phosphate-activated , L-glutaminase , glutaminase liver isoform, mitochondrial , liver mitochondrial glutaminase

525335 Bos taurus
488448 Canis lupus familiaris
399525 Sus scrofa
14660 Mus musculus
100069617 Equus caballus
470606 Pan troglodytes
5620641 Bacillus pumilus SAFR-032
564746 Danio rerio
424043 Gallus gallus
36396 Drosophila melanogaster
172547 Caenorhabditis elegans
174282 Caenorhabditis elegans
1086611 Bacillus anthracis str. Ames
2815154 Bacillus anthracis str. 'Ames Ancestor'
9173316 Arcobacter nitrofigilis DSM 7299
10145336 Cellulophaga algicola DSM 14237
10252085 Odoribacter splanchnicus DSM 220712
10253226 Odoribacter splanchnicus DSM 220712
10262273 Cellulophaga lytica DSM 7489
10283366 Weeksella virosa DSM 16922
10828538 Mesorhizobium opportunistum WSM2075
2744 Homo sapiens
24398 Rattus norvegicus
216456 Mus musculus
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