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Granulysin Proteins (GNLY)

The product of GNLY is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Additionally we are shipping Granulysin Antibodies (78) and Granulysin Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNLY 10578 P22749
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Top Granulysin Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_NSO cells Human Un-conjugated 4 pack Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
Human Un-conjugated   2 μg Log in to see 6 Days

GNLY Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,

Top referenced Granulysin Proteins

  1. Human GNLY Protein expressed in NSO cells - ABIN2666969 : Kalb, Glaser, Stary, Koszik, Stingl: TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)
    Show all 3 references for ABIN2666969

More Proteins for Granulysin (GNLY) Interaction Partners

Human Granulysin (GNLY) interaction partners

  1. Carbamate pesticides significantly reduced the intracellular levels of perforin (show PRF1 Proteins), GrA (show NR3C1 Proteins), GrB, Gr3 (show PRLHR Proteins)/K, and GRN (show GRN Proteins) in NK-92CI cells.

  2. serum GNLY is closely associated with the clinical characteristics of nasopharyngeal carcinoma and may be a potential biomarker for nasopharyngeal carcinoma

  3. GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite.

  4. Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand (show TNFSF10 Proteins)) seem to be less secondary effects on normal tissues.

  5. High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome.

  6. A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance.

  7. GNLY-expressing lymphocytes, probably attracted by IL-15 (show IL15 Proteins), not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in patients with myocardial infarction.

  8. Serum granulysin levels were significantly elevated in both acute and chronic alopecia areata patients.

  9. Human, but not rodent, cytotoxic granules also contain granulysin, an antimicrobial peptide (show cAMP Proteins) in addition to granzymes; study shows that granulysin delivers granzymes into bacteria to kill diverse bacterial strains.

  10. It was concluded taht granulysin induces apoptosis on hematological tumor cells and on cells from B-cell lymphocytic leukemia patients, opening the door to research on its use as a new anti-tumoral treatment.

Cow (Bovine) Granulysin (GNLY) interaction partners

  1. Intercaruncular epithelium granulysin may play important roles in the establishment and maintenance of gestation during normal pregnancy.

Granulysin (GNLY) Protein Profile

Protein Summary

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Granulysin Proteins (GNLY)

  • granulysin (GNLY)
  • 519 protein
  • D2S69E protein
  • LAG-2 protein
  • LAG2 protein
  • NKG5 protein
  • TLA519 protein

Protein level used designations for Granulysin Proteins (GNLY)

granulysin , T-cell activation protein 519 , T-lymphocyte activation gene 519 , lymphocyte-activation gene 2 , lymphokine LAG-2

459370 Pan troglodytes
100125622 Ovis aries
10578 Homo sapiens
404173 Bos taurus
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