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HLA Class I alpha F Proteins (HLAF)

HLAF belongs to the HLA class I heavy chain paralogues. Additionally we are shipping HLA Class I alpha F Antibodies (32) and HLA Class I alpha F Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLAF 3134 P30511
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Top HLA Class I alpha F Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days

HLAF Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for HLA Class I alpha F (HLAF) Interaction Partners

Human HLA Class I alpha F (HLAF) interaction partners

  1. Overexpression of a single MHCI molecule, HLA-F, protects human MNs (show FLNA Proteins) from ALS (show IGFALS Proteins) astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2 (show KIR3DL2 Proteins), on human astrocytes results in enhanced motor neurons death

  2. We identified that the HLA-E and HLA-F in gastric cancer independently affected clinical factors, including postoperative outcome

  3. Review of the impact of human leukocyte antigen (show HLADRB4 Proteins) molecules E, F, and G on the outcome of transplantation.

  4. This is the first study regarding HLA-F polymorphisms in a Euro-Brazilian population contributing to the Southern Brazilian genetic characterization.

  5. The effect of Japanese encephalitis virus and TNF-alpha exposure on NFkappaB-mediated induction of HLA-F is reported.

  6. A previously unrecognized model of Ag cross-presentation mediated by HLA-F & MHC-I open conformers on activated lymphocytes & monocytes may significantly contribute to the regulation of immune system functions & the immune defense.

  7. HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

  8. Upregulated HLA-F expression (p = 0.026) and downregulated HLA I expression (p = 0.013) could be an independent unfavorable prognostic factor.

  9. Mifepristone can inhibit the effects of progesterone by down-regulating the expressions of HLA-G, HLA-E and HLA-F mRNA in trophoblasts during the first trimester.

  10. These data suggest that HLA-F is expressed independently of peptide and that a physical interaction specific to MHC-I HC plays a role in the function of MHC-I HC expression in activated lymphocytes.

HLA Class I alpha F (HLAF) Protein Profile

Protein Summary

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

Gene names and symbols associated with HLA Class I alpha F Proteins (HLAF)

  • major histocompatibility complex, class I, F (HLA-F)
  • CDA12 protein
  • HLA-5.4 protein
  • HLA-CDA12 protein
  • HLAF protein

Protein level used designations for HLA Class I alpha F Proteins (HLAF)

HLA F antigen , HLA class I histocompatibility antigen, alpha chain F , HLA class I molecule , MHC class I antigen F , MHC class Ib antigen , leukocyte antigen F

3134 Homo sapiens
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