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HLA Class II DR beta 4 Proteins (HLADRB4)

HLA-DRB4 belongs to the HLA class II beta chain paralogues. Additionally we are shipping HLA Class II DR beta 4 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLADRB4 3126 P13762
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Top HLA Class II DR beta 4 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

HLADRB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for HLA Class II DR beta 4 (HLADRB4) Interaction Partners

Human HLA Class II DR beta 4 (HLADRB4) interaction partners

  1. HLA-DRB4 affects type 1 diabetes risk and islet autoantibodies.

  2. The study identifies a region of focus for B and T cell responses to IA-2 (show PTPRN Proteins) in HLA-DR4 diabetic patients that may explain HLA associations of IA-2 (show PTPRN Proteins) autoantibodies.

  3. HLA-DR4 codes for susceptibility to RF+ polyarticular JIA with a six-fold risk.

  4. The HLA- DR4 gene was clearly associated with susceptibility to rheumatoid arthritis.

  5. There was a strong association of aspirin resistant thrombophilia with expression of HLA-DRB4 and HLA-DQA1 (show HLA-DQA2 Proteins).

  6. Heterozygosity of HLA-DRB3 (show HLA-DRB3 Proteins)*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.

  7. Data indicate that invariant NKT (iNKT) cell-mediated cytokine secretion in staphylococcal enterotoxin B (SEB)-challenged HLA-DR4-transgenic mice was CD1d-independent.

  8. There are no significant differences in the HLA-DRB3 (show HLA-DRB3 Proteins)/B4/B5 homozygosity and heterozygosity rates between Korean males and females in both newborns and adults.

  9. Elevated frequencies of HLA-DR4 and HLA-DR5 (show TNFRSF10B Proteins) alleles were found in patients with idiopathic dilated cardiomyopathy compared with controls.

  10. DRB4*01:08 is a novel HLA-DRB4 allele

HLA Class II DR beta 4 (HLADRB4) Protein Profile

Protein Summary

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Gene names and symbols associated with HLADRB4

  • major histocompatibility complex, class II, DR beta 4 (HLA-DRB4)
  • DR-4 protein
  • DR4 protein
  • DRB4 protein
  • HLA-DR4B protein

Protein level used designations for HLADRB4

DRB1 transplantation antigen , HLA class II histocompatibility antigen, DR beta 4 chain , MHC HLA DR-beta chain , MHC class II antigen DRB4 , MHC class II antigen HLA-DR-beta , MHC class2 antigen , human leucocyte antigen DRB4 , leukocyte antigen

3126 Homo sapiens
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