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Hairy and Enhancer of Split 4 Proteins

(Hairy and Enhancer of Split 4 (HES4))
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor- dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer\; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).
HES4 Protein (AA 1-221) (GST tag) HES4 Protein (AA 1-221) (GST tag) HES4 Protein (AA 1-221) (GST tag) (ABIN1306551)

HES4 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA

HES4 Protein (AA 1-221) (Strep Tag) HES4 Protein (AA 1-221) (Strep Tag) HES4 Protein (AA 1-221) (Strep Tag) (ABIN3081428)

Crystallography grade HES4 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

HES4 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) HES4 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) HES4 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2722664)

HES4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

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Hairy and Enhancer of Split 4 Proteins by Origin

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Hairy and Enhancer of Split 4 Proteins by Source

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Hairy and Enhancer of Split 4 Proteins by Application

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Popular Hairy and Enhancer of Split 4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306551
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3081428
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2722664
Quantity 20 μg
Datasheet Datasheet
Reactivity Xenopus laevis
Source Yeast
Validations
Cat. No. ABIN1639349
Quantity 1 mg
Datasheet Datasheet
Reactivity Xenopus laevis
Source Yeast
Validations
Cat. No. ABIN1640267
Quantity 1 mg
Datasheet Datasheet

Aliases for Hairy and Enhancer of Split 4 Proteins

hes family bHLH transcription factor 4 (HES4) Proteins
hes family bHLH transcription factor 4 (hes4) Proteins
hes family bHLH transcription factor 4 L homeolog (hes4.L) Proteins
hes family bHLH transcription factor 4 S homeolog (hes4.S) Proteins
bHLHb42 Proteins
hairy2 Proteins
hairy2a Proteins
hairy2b Proteins
hes1 Proteins
hes4a Proteins
hes4b Proteins
Xhairy2 Proteins
XHairy2a Proteins
Xhairy2a Proteins
Xhairy2b Proteins
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