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Transcriptional repressor. Additionally we are shipping HES4 Antibodies (41) and many more products for this protein.
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Hes4 overexpression promotes a more aggressive tumor phenotype by preventing osteoblastic differentiation of osteosarcoma cells. Hes4 expression may allow for the stratification of patients into good or poor responders to chemotherapy at diagnosis.
Overexpression and knockdown studies demonstrated that Hes4 promotes osteogenesis resulting in an increase in Runx2 (show RUNX2 Proteins), osteocalcin (show BGLAP Proteins), osteopontin (show SPP1 Proteins), and bone sialoprotein (show CRISP1 Proteins) expression in BMSC.
Epigenetic dysregulation of HES4 could play a critical role in modifying Huntington's disease pathogenesis and severity.
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor- dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer\; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).
, hairy and enhancer of split 1
, transcription factor HES-4
, bHLH factor Hes4
, class B basic helix-loop-helix protein 42