Hairy and Enhancer of Split 4 (Drosophila) Proteins (HES4)

Transcriptional repressor. Additionally we are shipping HES4 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HES4 57801 Q9HCC6
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Top HES4 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

HES4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Hairy and Enhancer of Split 4 (Drosophila) (HES4) Interaction Partners

Human Hairy and Enhancer of Split 4 (Drosophila) (HES4) interaction partners

  1. Hes4 overexpression promotes a more aggressive tumor phenotype by preventing osteoblastic differentiation of osteosarcoma cells. Hes4 expression may allow for the stratification of patients into good or poor responders to chemotherapy at diagnosis.

  2. Overexpression and knockdown studies demonstrated that Hes4 promotes osteogenesis resulting in an increase in Runx2 (show RUNX2 Proteins), osteocalcin (show BGLAP Proteins), osteopontin (show SPP1 Proteins), and bone sialoprotein (show CRISP1 Proteins) expression in BMSC.

  3. Epigenetic dysregulation of HES4 could play a critical role in modifying Huntington's disease pathogenesis and severity.

HES4 Protein Profile

Protein Summary

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor- dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer\; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).

Gene names and symbols associated with HES4

  • hairy and enhancer of split 4 (hes4)
  • hairy and enhancer of split 4 (Drosophila) (HES4)
  • bHLHb42 protein
  • hairy2 protein
  • hairy2a protein
  • hairy2b protein
  • hes1 protein
  • hes4a protein
  • hes4b protein
  • Xhairy2 protein
  • XHairy2a protein
  • Xhairy2b protein

Protein level used designations for HES4

Protein hairy-2 , hairy and enhancer of split 1 , transcription factor HES-4 , bHLH factor Hes4 , class B basic helix-loop-helix protein 42 , hHES4

394465 Xenopus (Silurana) tropicalis
57801 Homo sapiens
507480 Bos taurus
489604 Canis lupus familiaris
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