Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) ELISA Kits

HRK encodes a member of the BCL-2 protein family. Additionally we are shipping HRK Antibodies (45) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HRK 8739 O00198
HRK 12123 P62816
HRK 117271 P62817
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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
96 Tests Log in to see 15 to 18 Days
96 Tests Log in to see 15 to 18 Days
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More ELISA Kits for HRK Interaction Partners

Human Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) interaction partners

  1. miR (show MLXIP ELISA Kits)-23a-3p, miR (show MLXIP ELISA Kits)-23b-3p, and miR (show MLXIP ELISA Kits)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (show BCL2 ELISA Kits) proteins DP5 and PUMA (show BBC3 ELISA Kits) and consequent human beta-cell apoptosis.

  2. our findings suggest that induction of the BH3-only (show BBC3 ELISA Kits) protein Hrk is a critical step in 2-ME activation of the JNK (show MAPK8 ELISA Kits)-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak (show BAK1 ELISA Kits).

  3. SUZ12 (show SUZ12 ELISA Kits) promotes the proliferation of human EOC cells by inhibiting apoptosis and HRK is a novel SUZ12 (show SUZ12 ELISA Kits) target gene whose upregulation contributes to apoptosis induced by SUZ12 (show SUZ12 ELISA Kits) knockdown.

  4. Diva (show BCL2L10 ELISA Kits) binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 (show BCL2 ELISA Kits) proteins, including mouse Harakiri, Bid (show BID ELISA Kits), Bak (show BAK1 ELISA Kits) and Bmf (show BMF ELISA Kits).

  5. The BH3-only (show BBC3 ELISA Kits) protein harakiri (HRK) is transactivated by ATF4 (show ATF4 ELISA Kits) in severe hypoxia through direct binding of ATF4 (show ATF4 ELISA Kits) to the promoter region.

  6. Data suggest that DP5 and PUMA/BBC3 (p53 up-regulated modulator of apoptosis (show BBC3 ELISA Kits)/bcl-2-binding component 3 (show BBC3 ELISA Kits)) contribute to palmitate-induced apoptosis of pancreatic beta-cells via lipotoxic endoplasmic reticulum stress.

  7. These results are used to propose a tentative structural model of how Harakiri works.

  8. analysis of a novel interaction between Bcl-2 (show BCL2 ELISA Kits) members Diva (show BCL2L10 ELISA Kits) and Harakiri

  9. Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection.

  10. apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells

Mouse (Murine) Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) interaction partners

  1. Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (show BCL2L1 ELISA Kits) (-/-) embryonic nervous system, indicating that other BH3-only (show BBC3 ELISA Kits) molecules, alone or in combination, may regulate BAX (show BAX ELISA Kits) activation in immature neurons.

  2. DP5 plays an important role in neuronal cell death induced by axotomy and NGF (show NGFB ELISA Kits) deprivation through the regulation of mitochondrial function and caspase-3 (show CASP3 ELISA Kits) activation

  3. These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells.

  4. in response to PAHs, Ahr (show AHR ELISA Kits)-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death.

  5. The effect of antisense oligonucleoties specific to the harakiri mRNA on spontaneous and induced defects of mouse preimplantation embryo development

HRK Antigen Profile

Antigen Summary

This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with HRK

  • harakiri, BCL2 interacting protein (contains only BH3 domain) (HRK) antibody
  • harakiri, BCL2 interacting protein (contains only BH3 domain) (Hrk) antibody
  • AI838259 antibody
  • Bid3 antibody
  • Dp5 antibody
  • harakiri antibody

Protein level used designations for HRK

BCL2-interacting protein , BH3-interacting domain-containing protein 3 , activator of apoptosis Hrk , activator of apoptosis harakiri , death protein 5 , neuronal death protein DP5 , BH3 interacting (with BCL2 family) domain, apoptosis agonist , BH3 interacting domain 3

8739 Homo sapiens
12123 Mus musculus
117271 Rattus norvegicus
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