Helicase-Like Transcription Factor Proteins (HLTF)

HLTF encodes a member of the SWI/SNF family. Additionally we are shipping HLTF Antibodies (79) and HLTF Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLTF 6596 Q14527
HLTF 20585 Q6PCN7
Rat HLTF HLTF 295568  
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Top HLTF Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days

HLTF Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,

More Proteins for Helicase-Like Transcription Factor (HLTF) Interaction Partners

Human Helicase-Like Transcription Factor (HLTF) interaction partners

  1. the present study does not provide any strong evidence that PAI-1 (show SERPINE1 Proteins) gene variants are implicated in the risk of DR or the development of DR during T2DM course.

  2. A large number of SNF2 (show SMARCA2 Proteins) family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1 (show SMARCAL1 Proteins), ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review]

  3. depletion of SMARCAL1 (show SMARCAL1 Proteins), a SNF2 (show SMARCA2 Proteins)-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1 (show SMARCAL1 Proteins), other SNF2 (show SMARCA2 Proteins)-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability

  4. HIV-1 vpr reprograms CRL4(DCAF1) E3 to direct HLTF for proteasome-dependent degradation independent from previously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2 (show UNG Proteins)) and crossover junction endonuclease MUS81 (show MUS81 Proteins), which Vpr also directs for degradation via CRL4(DCAF1) E3.

  5. Fasudil reduced LPS (show IRF6 Proteins)-mediated TF and PAI-1 (show SERPINE1 Proteins) expression and activity in PBMCs. These effects may partially be relevant to the clinical benefits of fasudil in the treatment of CAPD patients.

  6. HLTF is degraded in lymphocytic cells and macrophages infected with Vpr-expressing HIV-1. Our results reveal a previously unidentified strategy for HIV-1 to antagonize DNA repair in host cells.

  7. HLTF expression is altered in various cancers via two mechanisms: gene silencing through promoter hypermethylation or alternative mRNA splicing, which leads to the expression of truncated proteins that lack DNA repair domains. [review]

  8. HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain.

  9. Findings indicate a mechanism of helicase-like transcription factor HLTF-mediated fork reversal and suggest the requirement for distinct fork remodeling activities in the cell.

  10. Study demonstrates a correlation between HLTF expression level and thyroid neoplastic progression where three truncated forms are detected in thyroid carcinoma.

Rabbit Helicase-Like Transcription Factor (HLTF) interaction partners

  1. Prolactin (show PRL Proteins) dependent Jak2 (show JAK2 Proteins) phosphorylation of RUSH.

  2. Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B (show ATP11B Proteins) are conserved in human and rabbit, the RFBP isoform is specific to rabbit.

Mouse (Murine) Helicase-Like Transcription Factor (HLTF) interaction partners

  1. silencing Hltf during heart organogenesis compromised DNA double-strand break repair, and caused aberrant collagen biogenesis altering the structural network that transmits cardiomyocyte force into muscle contraction

  2. Data show a role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain

  3. p11 (show S100A10 Proteins) and AnxA2 (show ANXA2 Proteins) cooperate to create a unique binding pocket, but the optimal binding condition is not achieved without conformational changes associated with target binding. Upon interaction with the SMARCA3 peptide, both Asp60 in p11 (show S100A10 Proteins) and Ser12 in AnxA2 (show ANXA2 Proteins) flip inward toward the peptide-binding groove, forming additional intermolecular hydrogen bonds.

  4. Results demonstrate that loss of HLTF function promotes the malignant transformation of intestinal or colonic adenomas to carcinomas by inducing genomic instability.

HLTF Protein Profile

Protein Summary

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.

Gene names and symbols associated with HLTF

  • helicase like transcription factor (HLTF)
  • helicase-like transcription factor (hltf)
  • helicase-like transcription factor L homeolog (hltf.L)
  • helicase like transcription factor (hltf)
  • helicase-like transcription factor (Hltf)
  • helicase like transcription factor (Hltf)
  • AF010600 protein
  • BC057116 protein
  • HIP116 protein
  • HIP116A protein
  • HLTF protein
  • HLTF1 protein
  • MGC131155 protein
  • P113 protein
  • RNF80 protein
  • RUSH protein
  • Smarca3 protein
  • Snf2l3 protein
  • wu:fc33f07 protein
  • ZBU1 protein

Protein level used designations for HLTF

helicase-like transcription factor , SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3 , DNA-binding protein/plasminogen activator inhibitor 1 regulator , DNA-binding protein/plasminogen activator inhibitor-1 regulator , RING finger protein 80 , SNF2-like 3 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 , sucrose nonfermenting protein 2-like 3 , sucrose nonfermenting-like 3 , RUSH 1 , RUSH-1 , TNF-response element-binding protein , helicase-like transcription factor-like protein

100058775 Equus caballus
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460766 Pan troglodytes
735224 Xenopus laevis
100404714 Callithrix jacchus
100431605 Pongo abelii
100471960 Ailuropoda melanoleuca
100555259 Anolis carolinensis
100580659 Nomascus leucogenys
100617443 Monodelphis domestica
6596 Homo sapiens
100009232 Oryctolagus cuniculus
20585 Mus musculus
295568 Rattus norvegicus
477106 Canis lupus familiaris
539633 Bos taurus
100520979 Sus scrofa
100716292 Cavia porcellus
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