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Hepatic Leukemia Factor Proteins (HLF)

HLF encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. Additionally we are shipping HLF Antibodies (41) and HLF Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLF 29452 Q9JHS1
HLF 13819 P97481
HLF 3131 Q16534
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Top HLF Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days

HLF Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human ,

Top referenced HLF Proteins

  1. Human HLF Protein expressed in Escherichia coli (E. coli) - ABIN667523 : Falvey, Fleury-Olela, Schibler: The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. in The EMBO journal 1995 (PubMed)
    Show all 2 references for ABIN667523

More Proteins for Hepatic Leukemia Factor (HLF) Interaction Partners

Mouse (Murine) Hepatic Leukemia Factor (HLF) interaction partners

  1. Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity

  2. Findings identify a reciprocal activation mechanism involving HIF-2alpha (show EPAS1 Proteins) and the zinc-ZIP8 (show SLC39A8 Proteins)-MTF1 (show MTF1 Proteins) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  3. This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha (show EPAS1 Proteins) and HIF-1alpha (show HIF1A Proteins).

  4. genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO (show EPO Proteins) production under conditions of epithelial HIF activation in the kidney.

  5. Chondrocytes co-cultured with HIF-2alpha (show EPAS1 Proteins)-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 (show MMP3 Proteins) and Mmp13 (show MMP13 Proteins), which is similar to the effects induced by interleukin (IL)-6 (show IL6 Proteins) treatment of chondrocytes.

  6. HIF-2alpha (show EPAS1 Proteins) inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha (show EPAS1 Proteins) promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

  7. Conditional expression of E2A (show TCF3 Proteins)-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.

  8. HIF-2alpha (show EPAS1 Proteins)-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Proteins)) and a dysfunctional thermogenic response to cold exposure.

  9. Loss of Hif-2alpha (show EPAS1 Proteins) Rescues the Hif-1alpha (show HIF1A Proteins) Deletion Phenotype of Neonatal Respiratory Distress In Mice

  10. although Hif-1alpha (show HIF1A Proteins) and Hif-2alpha (show EPAS1 Proteins) synergize to suppress the development of acute myeloid leukemia (show BCL11A Proteins), they are not required for leukemic stem cells maintenance.

Human Hepatic Leukemia Factor (HLF) interaction partners

  1. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3 (show TCF3 Proteins)-HLF (show EPAS1 Proteins) ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.

  2. ectopic expression of HLF (show EPAS1 Proteins), an established transcription factor that cycles with circadian rhythms, can recapitulate many features associated with circadian-dependent physiological variation.

  3. both Lmo2 (show LMO2 Proteins) and Bcl-2 (show BCL2 Proteins) are required for the action of E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) in leukemogenesis

  4. E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) promotes cell survival of t(17;19)- acute lymphoblastic leukemia cells by aberrantly up-regulating LMO2 (show LMO2 Proteins) expression

  5. Evidence pertaining to leukemogenesis by the well-characterized oncogenic fusion protein E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) is reviewed and its mechanistic implications are considered.

  6. E2A-HLF induces annexin II by substituting for cytokines that activate downstream pathways of Ras

  7. The E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins)-mediated over-expression of ABCB1 (show ABCB1 Proteins) may play a role in the clinical phenotype of ALLs with a t(17;19), suggesting pharmacologic modulation of ABCB1 (show ABCB1 Proteins) activity as a rational therapeutic strategy for this chemotherapy resistant subtype of ALL.

  8. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: E2A (show TCF3 Proteins)/PBX1 (show PBX1 Proteins) and E2A (show TCF3 Proteins)/HLF (show EPAS1 Proteins).

  9. In childhood acute lymphoblastic leukemia and hypercalcemia, translocation was observed in E2A (show TCF3 Proteins)-HLF (show EPAS1 Proteins) fusion protein.

  10. Activation of the thyroid hormone receptor beta (show THRB Proteins)/retinoid X receptor alpha (show RXRA Proteins) heterodimer by T(3) stimulated expression of the hepatic leukemia factor, which increases HIF-1alpha (show HIF1A Proteins) gene expression.

HLF Protein Profile

Protein Summary

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with Hepatic Leukemia Factor Proteins (HLF)

  • hepatic leukemia factor (HLF)
  • hepatic leukemia factor (Hlf)
  • hepatic leukemia factor a (hlfa)
  • Hepatic leukemia factor (Bm1_18395)
  • Hepatic leukemia factor (hlf)
  • endothelial PAS domain protein 1 (Epas1)
  • bHLHe73 protein
  • DKFZp469P0721 protein
  • E230015K02Rik protein
  • HIF-2alpha protein
  • HIF2A protein
  • Hlf protein
  • HLF1 protein
  • HRF protein
  • MOP2 protein
  • zgc:153035 protein

Protein level used designations for Hepatic Leukemia Factor Proteins (HLF)

hepatic leukemia factor , hepatic leukemia factor 1 , zhlf1 , Hepatic leukemia factor , EPAS-1 , HIF-2 alpha , HIF-2-alpha , HIF2 alpha , HIF2-alpha , endothelial PAS domain-containing protein 1 , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , HIF-1-alpha-like factor , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF

706623 Macaca mulatta
516069 Bos taurus
100192429 Ovis aries
100171535 Pongo abelii
593063 Strongylocentrotus purpuratus
417395 Gallus gallus
455140 Pan troglodytes
768192 Danio rerio
6098588 Brugia malayi
100380463 Salmo salar
29452 Rattus norvegicus
13819 Mus musculus
3131 Homo sapiens
217082 Mus musculus
363667 Rattus norvegicus
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