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Hexokinase 1 Proteins (HK1)

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Additionally we are shipping Hexokinase 1 Antibodies (225) and Hexokinase 1 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HK1 3098 P19367
HK1 15275  
HK1 25058 P05708
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Top Hexokinase 1 Proteins at

Showing 10 out of 49 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Human Twin-Strep tag   0.025 mg Log in to see 2 to 3 Days
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
Yeast Nicotiana tabacum His tag   1 mg Log in to see 56 to 66 Days

HK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)

Rat (Rattus)

Top referenced Hexokinase 1 Proteins

  1. Human Hexokinase 1 Protein expressed in Escherichia coli (E. coli) - ABIN668037 : Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997 (PubMed)
    Show all 2 references for ABIN668037

More Proteins for Hexokinase 1 (HK1) Interaction Partners

Human Hexokinase 1 (HK1) interaction partners

  1. Data suggest that overexpression of hexokinase 1 (HK1) may act as a significant biomarker of poor prognosis for patients with colorectal cancer (CRC (show CALR Proteins)).

  2. 4-hydroxytamoxifen resistance in breast cancer cells is suppressed by curcumin, which targets the SLUG (show SNAI2 Proteins)/Hexokinase 2 (show HK2 Proteins) pathway

  3. Our results suggest that overexpression of PKM2 and HK1 (show KCNA4 Proteins), especially the latter, significantly associates with lymphatic metastasis, advanced clinical staging and unfavorable prognosis in gastric cancer.

  4. HK1 (show KCNA4 Proteins) and HK2 (show HK2 Proteins) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 Proteins) expression level was significantly increased in 60% of samples.

  5. Data indicate a missense mutation in hexokinase 1 (HK1) c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members.

  6. HK1 expression is highly enriched in neurons compared to astrocytes in the cerebral cortex.

  7. HK-1 (show KCNA4 Proteins) plays a non-metabolic role in HIV-1 infected macrophages by binding to mitochondria thereby maintaining mitochondrial integrity.

  8. The present study was designed to evaluate the involvement of hexokinase and CPT-1 (show CPT1A Proteins) in the cell growth and proliferation of human prostate cancer cell lines, PC3 (show PCSK1 Proteins), and LNCaP-FGC-10.

  9. HK1 (show KCNA4 Proteins) is expressed in retina, with two abundant isoforms expressed at similar levels. The Glu847Lys mutation is located at a highly conserved position in the protein, outside the catalytic domains.

  10. Here, we identified HK1 (show KCNA4 Proteins) as a novel causative gene for adRP (show PLIN2 Proteins). This is the first report that associates the glucose metabolic pathway with human retinal degenerative disease, suggesting a potential new disease mechanism.

Mouse (Murine) Hexokinase 1 (HK1) interaction partners

  1. Hexokinase expression is highly enriched in neurons compared to astrocytes.

  2. The interaction of DREAM with hexokinase I may be important in the regulation of neuronal apoptosis.

  3. Standard chow affects body weight, heart weight and HK activity and HKI expression in the heart, without altering HKII (show HK2 Proteins) expression.

  4. HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 (show GSTM5 Proteins) in the fibrous sheath of sperm.

  5. HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 (show PRDM1 Proteins) and Xbp-1 (show XBP1 Proteins) in B cells.

  6. The comprehensive sequencing analysis and fine mapping approximately 26 kb of fully characterised sequence spanning the upstream exons of Hexokinase 1 (HK1), is reported.

  7. A new spontaneous mutation in the A/J inbred mouse strain, downeast anemia (dea), causes severe hemolytic anemia with extensive tissue iron deposition and marked reticulocytosis

  8. the Hexokinase-mitochondria interaction mediated by Akt (show AKT1 Proteins) has a role in inhibiting apoptosis but does not require Bax (show BAX Proteins) and Bak (show BAK1 Proteins)

  9. RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11 (show COX11 Proteins), and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.

  10. Between these two strategies to activate glycogen (show GYS1 Proteins) deposition in the absence of GK, embryonic livers choose to express massive levels of HKI and HKII (show HK2 Proteins).

Arabidopsis thaliana Hexokinase 1 (HK1) interaction partners

  1. role in cell death mediated by myo-inositol accumulation

  2. The structure of HXK1 was determined both in its inactive unliganded form and in its active glucose-bound form at resolutions of 1.8 and 2.0 A, respectively.

  3. The CO2 metabolism of the gin2-1 mutation in A. thaliana is reported.

  4. HXK1 mediated stimulation of NRT2.1 expression.

  5. Data suggest that regulation of NIA1 and NIA2 nitrate reductases (NR) activity by sugars does not involve HXK1 as a glucose sensor.

  6. Overexpression of AtHXK1 inhibits growth and accelerates leaf senescence under normal growth conditions.

  7. HKL1 (show ZNF354A Proteins) and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.

  8. HXK1-dependent glucose signaling uncoupled from other plant stress and defense hormone signaling has a central regulatory role in early seedling establishment.

Hexokinase 1 (HK1) Protein Profile

Protein Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus\; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Gene names and symbols associated with Hexokinase 1 Proteins (HK1)

  • hexokinase 1 (HK1)
  • hexokinase 1 (hk1)
  • Hexokinase 1 (Hex1)
  • hexokinase 1 (TA19800)
  • hexokinase 1 (Hk1)
  • hexokinase 1 (HXK1)
  • ATHXK1 protein
  • BB404130 protein
  • dea protein
  • F19B15.160 protein
  • F19B15_160 protein
  • GIN2 protein
  • HEX protein
  • HEX-1 protein
  • HEXOKIN protein
  • HEXOKINASE protein
  • hexokinase-1 protein
  • hexokinase 1 protein
  • HK protein
  • Hk-1 protein
  • HK1 protein
  • Hk1-s protein
  • HK1-ta protein
  • HK1-tb protein
  • HK1-tc protein
  • HKD protein
  • HKI protein
  • HMSNR protein
  • HXK1 protein
  • im:7148527 protein
  • mHk1-s protein
  • wu:fc09d08 protein
  • wu:fc16e02 protein
  • wu:fc21e02 protein
  • wu:fq14b11 protein
  • zgc:55790 protein
  • zgc:77618 protein

Protein level used designations for Hexokinase 1 Proteins (HK1)

HK I , hexokinase type I , hexokinase-1 , hexokinase 1 , hexokinase-1-like , brain form hexokinase , glycolytic enzyme , downeast anemia , hexokinase, tumor isozyme , DrHXK1 , hexokinase I

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100136279 Oncorhynchus mykiss
100127450 Sus scrofa
5657742 Drosophila melanogaster
450505 Pan troglodytes
281771 Bos taurus
3863904 Theileria annulata strain Ankara
100031311 Monodelphis domestica
100413117 Callithrix jacchus
3098 Homo sapiens
15275 Mus musculus
25058 Rattus norvegicus
406791 Danio rerio
280817 Bos taurus
100340945 Oryctolagus cuniculus
100730936 Cavia porcellus
479234 Canis lupus familiaris
100152344 Sus scrofa
373889 Gallus gallus
100036759 Ovis aries
829034 Arabidopsis thaliana
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