Histidine Triad Nucleotide Binding Protein 1 (HINT1) ELISA Kits

The protein encoded by HINT1 can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. Additionally we are shipping HINT1 Antibodies (62) and HINT1 Proteins (16) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HINT1 3094 P49773
HINT1 15254 P70349
HINT1 690660 P62959
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More ELISA Kits for HINT1 Interaction Partners

Human Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

  1. Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides). These results provide mechanistic insights underpinning histidine nucleophilic catalysis in general and human Hint1 catalysis, in particular, thus aiding the design of future proTides and the elucidation of the natural function of the Hint family of enzymes.

  2. We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies--{REVIEW}

  3. Underexpression of Hint1 is associated with invasion of hepatocellular carcinoma.

  4. first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide

  5. Absence of HINT1 mutations in a UK and Spanish cohort of patients with inherited neuropathies

  6. In hepatocellular carcinoma, HINT1 is a regulator of IkappaBalpha (show NFKBIA ELISA Kits) through SCF (show KITLG ELISA Kits)(beta-TrCP (show BTRC ELISA Kits)) E3 ligase.

  7. HINT1 mutations seem to be one of the most frequent causes of inherited neuropathy and are probably the most frequent cause of HMN in Czech patients. We suggest all HMN/CMT2 patients be tested for the presence of the prevalent mutation, the p.R37P

  8. The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB.

  9. Data suggest that histidine triad nucleotide binding protein 1 (HINT1) should be added to the list of genes to check for in distal hereditary motor neuropathies (dHMNs).

  10. Study gives suggestive evidence that HINT1 rs3852209 may be related to smoking status in Chinese men.

Mouse (Murine) Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

  1. The absence of Hint1 gene enhances supraspinal nociceptive sensitivity in mice, including thermal, mechanical and inflammatory hyperalgesia.

  2. It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 (show GRIN1 ELISA Kits) subunits in a calcium-independent manner, whereas sigma1R (show SIGMAR1 ELISA Kits) binding to these proteins increases in the presence of calcium.

  3. Results suggest that Hint1 deficiency leads to an increased protein level of PKC gamma (show PRKCG ELISA Kits) in the brain and a compromised activation response of PKC gamma (show PRKCG ELISA Kits) upon stimulation

  4. HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.

  5. These results further support a role for HINT1 in nicotine-mediated behaviors and suggest that alterations in the gene may have differential effects on phenotype in males and females.

  6. Activated mu-opioid receptors stimulate the production of nitric oxide (NO), and the redox zinc switch RGSZ2 (show RGS17 ELISA Kits) converts this signal into free zinc ions that are required to recruit the redox sensor PKCgamma (show PRKCG ELISA Kits) to HINT1 proteins.

  7. lipidomic phenotype of the Hint1(-/-) mouse

  8. these mice do not provide a disease model or a means for investigating the basis of HINT1-associated neuropathy and neuromyotonia

  9. Cannabinoids that act through CNR1 (show CNR1 ELISA Kits) maintain the negative control of HINT1 on NMDAR (show GRIN1 ELISA Kits) function and their protection against glutamate (show GRIN1 ELISA Kits) excitotoxic insult persists.

  10. our data support a role for the HINT1 gene in mediating behaviors associated with nicotine reward and physical nicotine withdrawal, and provide insight into the role of HINT1 in nicotine dependence-like behaviors.

Rabbit Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

  1. structure of the rabbit HINT1-adenosine complex is reported at 1.10 A resolution, which is one of the highest resolutions obtained for a HINT1 structure

HINT1 Antigen Profile

Antigen Summary

The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene.

Gene names and symbols associated with HINT1

  • histidine triad nucleotide binding protein 1 (HINT1) antibody
  • histidine triad nucleotide binding protein 1 (hint1) antibody
  • histidine triad nucleotide binding protein 1 (Hint1) antibody
  • Protein HINT-1 (hint-1) antibody
  • AA673479 antibody
  • CHPKCI antibody
  • Hint antibody
  • HINTZ antibody
  • Ipk1 antibody
  • NMAN antibody
  • Pkci antibody
  • PKCI-1 antibody
  • PKCIZ antibody
  • Prkci antibody
  • PRKCNH1 antibody
  • zgc:103764 antibody

Protein level used designations for HINT1

histidine triad nucleotide binding protein 1 , PKCI-Z-related protein , adenosine 5'-monophosphoramidase , histidine triad nucleotide-binding protein 1 , protein kinase C inhibitor 1 , protein kinase C-interacting protein 1 , PKC inhibitor/ interacting protein , 17 kDa inhibitor of protein kinase C , PKCI-1 , protein kinase C, iota , histidine triad missing Z , protein kinase C inhibitor , P13.7

462040 Pan troglodytes
548919 Xenopus (Silurana) tropicalis
751976 Taeniopygia guttata
3094 Homo sapiens
15254 Mus musculus
690660 Rattus norvegicus
449551 Danio rerio
447082 Xenopus laevis
395424 Gallus gallus
327693 Bos taurus
100009302 Oryctolagus cuniculus
474667 Canis lupus familiaris
100171549 Pongo abelii
184760 Caenorhabditis elegans
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