Histone Cluster 1, H1c Proteins (HIST1H1C)

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Additionally we are shipping HIST1H1C Antibodies (38) and HIST1H1C Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HIST1H1C 3006 P16403
HIST1H1C 50708 P15864
HIST1H1C 201097 P15865
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Top HIST1H1C Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

HIST1H1C Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Histone Cluster 1, H1c (HIST1H1C) Interaction Partners

Human Histone Cluster 1, H1c (HIST1H1C) interaction partners

  1. BRG1 (show SMARCA4 Proteins) participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.

  2. Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells.

  3. Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 (show KRT26 Proteins) modifications are essential for proper cell cycle progression.

  4. H1.2 interacts with Cul4A (show CUL4A Proteins) and PAF1 (show PEX2 Proteins) to activate developmental regulatory genes.

  5. H1.2 is less abundant than other histone H1 (show H1F0 Proteins) variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 (show H1F0 Proteins) variants and tend to be repressed.

  6. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.

  7. These data suggest that p53 (show TP53 Proteins) acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53 (show TP53 Proteins)-dependent DNA damage response pathways.

  8. confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (show CDK1 Proteins) (CDK (show CDK4 Proteins)) consensus motif

  9. The binding of histone H1 (show H1F0 Proteins) to a general amyloid-like motif indicates that histone H1 (show H1F0 Proteins) may play an important common role in diseases associated with amyloid-like fibrils.

  10. Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak (show BAK1 Proteins) in mitochondria.

Mouse (Murine) Histone Cluster 1, H1c (HIST1H1C) interaction partners

  1. Histone H1c gene expression is developmentally up-regulated to promote facultative heterochromatin in mature rod photoreceptors.

  2. These results integrate the localization of an understudied type of chromatin proteins, namely the H1 variants, into the epigenome map of mouse ESCs (show NR2E3 Proteins).

  3. The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 (show H1F0 Proteins) and H1c.

  4. The amount of the linker histone H1c is strongly reduced in nuclear extracts of SCA7 retinas and that the cellular distribution of H1c is particularly altered in the facultative heterochromatin compartment.

  5. The modular pattern of DNA methylation (show HELLS Proteins) in the Ig heavy chain locus and histone modifications appears to be determined by at least 2 factors: the B-cell-specific transcription factor Pax5 (show PAX5 Proteins) and linker histone H1 (show H1F0 Proteins).

  6. These observations reveal a mode of p53 (show TP53 Proteins) regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (show TP53 Proteins) function through recruitment of histone H1 (show H1F0 Proteins).

  7. H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms

HIST1H1C Protein Profile

Protein Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Gene names and symbols associated with HIST1H1C

  • histone cluster 1, H1c (HIST1H1C)
  • histone cluster 1, H1.11L (HIST1H111L)
  • histone cluster 1 H1 family member c (HIST1H1C)
  • histone cluster 1, H1c (Hist1h1c)
  • histone cluster 1, H1d (Hist1h1d)
  • 0610008C09Rik protein
  • H1.2 protein
  • H1c protein
  • H1d protein
  • H1f2 protein
  • H1f4 protein
  • H1s-1 protein
  • H1var1 protein
  • H14 protein
  • His1a protein
  • Hist1h1c protein
  • Hist1h1e protein

Protein level used designations for HIST1H1C

CTL-1 , histone H1.1 , histone H1.2 , histone H1d , histone 1, H1c , histone H1.11L , H1 histone family, member 2 , histone H1c , histone H1s-1 , H1 VAR.1 , histone H1 , H1 histone family, member 4 , Histone 1d , histone H1.4

513971 Bos taurus
427892 Gallus gallus
3006 Homo sapiens
50708 Mus musculus
201097 Rattus norvegicus
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