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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping Histone Deacetylase 5 Antibodies (157) and Histone Deacetylase 5 Proteins (6) and many more products for this protein.
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Formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT (show ITK ELISA Kits) through inhibition of HDAC5.
These results suggest a strong regulatory function of HDAC5 in the pro-inflammatory response of macrophages.
In erythroid cells, pull down experiments identified the presence of a novel complex formed by HDAC5, GATA1, EKLF and pERK which was instead undetectable in cells of the megakaryocytic lineage.
Data reveal a novel role of HDAC5 in modulating the KLF2 (show KLF2 ELISA Kits) transcriptional activation and eNOS (show NOS3 ELISA Kits) expression.
Studied phosphorylation sites within functional HDAC5 domains, including the deacetylation domain (DAC (show AADAC ELISA Kits), Ser755), nuclear export signal (NES (show NES ELISA Kits), Ser1108), and an acidic domain (AD, Ser611).
mRNA and protein levels of HDAC5 were up-regulated in human hepatocellular carcinoma.
HDAC5 promoted the Six1 (show SIX1 ELISA Kits) expression.
In C2C12 myoblasts, recombinant human HDAC5 phosphorylation by PKD (show PRKD1 ELISA Kits) regulated the expression of diverse metabolic genes and glucose metabolism.
findings show N-Myc (show MYCN ELISA Kits) upregulated HDAC5 expression in neuroblastoma (show ARHGEF16 ELISA Kits) cells; HDAC5 repressed NEDD4 (show NEDD4 ELISA Kits) gene expression,increased Aurora A (show AURKA ELISA Kits) gene expression and consequently upregulated N-Myc protein (show MYCN ELISA Kits) expression;data identify HDAC5 as a novel co-factor in N-Myc (show MYCN ELISA Kits) oncogenesis
we show that Stat3 binds to the promoter region of PTPN13 and promotes its activity through recruiting HDAC5. Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development
Results suggest a role for Hdac5 and Sirt2 (show SIRT2 ELISA Kits) in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression
loss of HDAC5 weakens Treg suppressive function and iTreg formation, as well as IFN-gamma (show IFNG ELISA Kits) production in CD8 (show CD8A ELISA Kits)+ T cells. Mice lacking HDAC5 do not develop spontaneous illness and do not have enhanced anti-tumor immunity.
functional loss or suppression of the tumor suppressor HDAC6 (show HDAC6 ELISA Kits) is caused by induction of miR (show MLXIP ELISA Kits)-221 through coordinated JNK/c-Jun- and NF-kappaB (show NFKB1 ELISA Kits)-signaling pathways during liver tumorigenesis
Hyperacetylation of Hsp90 (show HSP90 ELISA Kits) is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 (show HDAC6 ELISA Kits) inhibitors increase Hsp90 (show HSP90 ELISA Kits) acetylation and modulate GR chaperone dynamics.
Soluble beta-amyloid disrupts actin and microtubule dynamics via activation of RhoA (show RHOA ELISA Kits) and inhibition of histone deacetylase 6 (show HDAC6 ELISA Kits) in cultured hippocampal neurons.
This study demonstrated that hdac6 (show HDAC6 ELISA Kits) increase in skeletal muscle in muscle atrophy.
Results indicate that Histone deacetylase 6 (show HDAC6 ELISA Kits) has neuroprotective effects in an animal model of amyotrophic lateral sclerosis.
Our results indicate that HDAC6 (show HDAC6 ELISA Kits) is a critical regulator of MFN2 (show MFN2 ELISA Kits) degradation by MARCH5 (show MARCH5 ELISA Kits), thus protecting mitochondrial connectivity from hypoxic stress.
An important role for HDAC6 (show HDAC6 ELISA Kits) in regulating the mammalian Hh pathway.
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
histone deacetylase 5
, antigen NY-CO-9
, histone deacetylase 4
, histone deacetylase mHDA1
, histone deacetylase mHDA2
, scurfy candidate 6