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anti-Histone Deacetylase 6 (HDAC6) Antibodies

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping Histone Deacetylase 6 Proteins (17) and Histone Deacetylase 6 Kits (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HDAC6 10013 Q9UBN7
HDAC6 15185 Q9Z2V5
HDAC6 84581  
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Top anti-Histone Deacetylase 6 Antibodies at

Showing 10 out of 250 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated ChIP, WB WB Suggested Anti-HDAC6 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 293T cell lysate Chromatin Immunoprecipitation (ChIP) Using HDAC6 Antibody - N-terminal region (ARP31451_P050) and HCT116 Cells 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of HDAC-6 expression with Jurkat cell lysate. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB The anti-HDAC6 Pab (ABIN387955) is used in Western blot to detect HDAC6 in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HDAC6 Antibody (C-term)(ABIN387955), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ChIP, WB HDAC6 pAb tested by Western blot. Detection of HDAC6 by Western blot. The analysis was performed using NIH/3T3 nuclear extract and HDAC6 pAb. A protein band of approximate molecular weight of 134 kDa was detected. 100 μg Log in to see 1 to 2 Days
Human Rabbit Un-conjugated ChIP, IP, SimWes, WB Simple Western: HDAC6 Antibody [ABIN43167603] - Simple Western lane view shows a specific band for HDAC6 in 0.5 mg/ml of NIH-3T3 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Western Blot: HDAC6 Antibody [ABIN43167603] - analysis of HDAC-6 in NIH 3T3 cell lysate with this antibody. 0.1 mg Log in to see 5 to 7 Days
Human Mouse Un-conjugated FACS, ICC, IF, IHC, IHC (p), WB Flow Cytometry: HDAC6 Antibody (1B3) [NBP2-03269] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-HDAC6 antibody, and then analyzed by flow cytometry. Immunocytochemistry/Immunofluorescence: HDAC6 Antibody (1B3) [NBP2-03269] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY HDAC6. 0.1 mL Log in to see 6 to 9 Days
Human Rabbit Un-conjugated ChIP, WB Chromatin Immunoprecipitation (ChIP) Using Hdac6 Antibody - C-terminal region (ARP38730_P050) and HCT116 Cells 100 μL Log in to see 2 to 3 Days

HDAC6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Histone Deacetylase 6 Antibodies

  1. Human Polyclonal HDAC6 Primary Antibody for IHC (p), WB - ABIN387955 : Hook, Orian, Cowley, Eisenman: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 6 references for ABIN387955

  2. Human Polyclonal HDAC6 Primary Antibody for EIA, IHC (p) - ABIN356649 : Wolffe: Transcriptional control. Sinful repression. in Nature 1997 (PubMed)
    Show all 4 references for ABIN356649

  3. Human Polyclonal HDAC6 Primary Antibody for ChIP, WB - ABIN2668292 : Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN2668292

  4. Human Polyclonal HDAC6 Primary Antibody for IHC, WB - ABIN223301 : Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 3 references for ABIN223301

  5. Cow (Bovine) Polyclonal HDAC6 Primary Antibody for ChIP, WB - ABIN2777306 : Voelter-Mahlknecht, Mahlknecht: Cloning and structural characterization of the human histone deacetylase 6 gene. in International journal of molecular medicine 2003 (PubMed)

More Antibodies against Histone Deacetylase 6 Interaction Partners

Fruit Fly (Drosophila melanogaster) Histone Deacetylase 6 (HDAC6) interaction partners

  1. HDAC6 is necessary and sufficient for BRP (show GDF5 Antibodies) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.

  2. Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (show TUBA4A Antibodies) proteostasis and disruption of the cardiomyocyte microtubule structure.

  3. From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.

  4. Overexpressing any of HDAC 3 (show HDAC3 Antibodies), 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 Antibodies) tremor ataxia (show USP14 Antibodies) syndrome.

  5. Data suggest that alpha-synuclein (show SNCA Antibodies) inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.

  6. findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy

  7. Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.

  8. Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (show EHMT2 Antibodies) to modify histone H3K9 and to determine cell fates.

  9. Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.

Human Histone Deacetylase 6 (HDAC6) interaction partners

  1. Data show that expressions of histone deacetylase 6 protein (HDAC6) and c-myc protein are increased in fibroblasts transformed with activated K-ras protein.

  2. Overexpression of HDAC6 confers non-small cell lung cancer resistance to sorafenib.

  3. these data indicate that HDAC6, and acetylated alpha-tubulin (show TUBA4A Antibodies), are important regulator of adipocyte differentiation.

  4. HDAC5 (show HDAC5 Antibodies) and HDAC6 were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.

  5. Study found that HDAC6 was significantly down-regulated in hepatocellular carcinoma cells (HCC (show FAM126A Antibodies)) and the low expression of HDAC6 was closely associated with high recurrence rate of HCC (show FAM126A Antibodies) patients with liver transplantation.

  6. results provide new mechanistic insights into the understanding that deacetylation of HSPA5 (show HSPA5 Antibodies) by HDAC6 facilitates GP78 (show AMFR Antibodies)-mediated HSPA5 (show HSPA5 Antibodies) ubiquitination

  7. TGF-beta (show TGFB1 Antibodies) increased activity of HDAC6 without affecting its expression levels.

  8. acetylation-mimicking mutants of alpha-tubulin (show TUBA4A Antibodies) and cortactin (show CTTN Antibodies) counteract HDAC6-induced ciliary disassembly.

  9. The inhibitory effect of nuclear HDAC6 on invasion of NSCLC was mediated by the deacetylation of the p65 (show GORASP1 Antibodies) subunit of nuclear factor-kappaB, which decreased its DNA-binding activity to the MMP2 (show MMP2 Antibodies) promoter, leading to the downregulation of MMP2 (show MMP2 Antibodies) expression.

  10. Evaluation of a collection of primary lymphoma samples for markers of the UPR revealed increased HDAC6.

Mouse (Murine) Histone Deacetylase 6 (HDAC6) interaction partners

  1. HDAC6-mediated autophagy negatively regulates primary cilia length during silibinin treatment and has the potential to serve as a therapeutic target for primary cilia-associated ciliopathies.

  2. HDAC6 is an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by cytotoxic T lymphocytes.

  3. It protects neurons from toxicity of prion (show PRNP Antibodies) peptide, and that this protection occurs at through the regulation of the PI3k-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) axis.

  4. mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6.

  5. We therefore tested that reducing HDAC6 levels by genetic manipulation would attenuate early cognitive and behavioral deficits in R6/1 mice

  6. HDAC6 plays an important role in the function of CMA pathway under the HI stress induced by SCI and it may be a potential therapeutic target in acute SCI model.

  7. functional loss or suppression of the tumor suppressor HDAC6 is caused by induction of miR (show MLXIP Antibodies)-221 through coordinated JNK/c-Jun- and NF-kappaB (show NFKB1 Antibodies)-signaling pathways during liver tumorigenesis

  8. Hyperacetylation of Hsp90 (show HSP90 Antibodies) is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 inhibitors increase Hsp90 (show HSP90 Antibodies) acetylation and modulate GR chaperone dynamics.

  9. Soluble beta-amyloid disrupts actin and microtubule dynamics via activation of RhoA (show RHOA Antibodies) and inhibition of histone deacetylase 6 in cultured hippocampal neurons.

  10. This study demonstrated that hdac6 increase in skeletal muscle in muscle atrophy.

Arabidopsis thaliana Histone Deacetylase 6 (HDAC6) interaction partners

  1. HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (show HELLS Antibodies) at CG dinucleotides.

  2. Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (show CD86 Antibodies)) in the root tip were affected in hda6 mutation.

  3. HDC1 is a ubiquitously expressed nuclear protein (show UBN1 Antibodies) that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.

  4. HDA6 and FLD (show LPIN1 Antibodies) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (show MBD2 Antibodies) through HDA6 and FLD (show LPIN1 Antibodies) interaction in flowering control.

  5. Taken together, these data indicate that HDA6 is a part of the AS1 repressor complex to regulate the KNOX expression in leaf development.

  6. HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.

  7. HDA6 and MET1 (show DNMT1 Antibodies) interact directly and act together to silence transposable elements by modulating DNA methylation (show HELLS Antibodies), histone acetylation, and histone methylation status.

  8. HDA6 and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.

  9. HDA6 is required for heterochromatic silencing, and the mutation results in loss of heterochromatic histone modification along with aberrant enrichment for euchromatic modification at HDA6 targets.

  10. HDA6 plays a critical role in regulating cold acclimation process that confers freezing resistance on Arabidopsis.

Histone Deacetylase 6 (HDAC6) Antigen Profile

Protein Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Gene names and symbols associated with HDAC6

  • CG6170 gene product from transcript CG6170-RA (HDAC6) antibody
  • histone deacetylase 6 (hdac6) antibody
  • DsimGD17207-PA (DsimHDAC6) antibody
  • histone deacetylase 6 (PTRG_03035) antibody
  • histone deacetylase 6 (HDAC6) antibody
  • histone deacetylase 6 (Hdac6) antibody
  • RPD3-like histone deacetylase (HDA6) antibody
  • ATHDA6 antibody
  • AXE1 antibody
  • CG6170 antibody
  • dHDAC2 antibody
  • dHDAC6 antibody
  • Dmel\\CG6170 antibody
  • dmHDA404 antibody
  • DmHDAC2 antibody
  • DsimGD17207 antibody
  • dsim_GLEANR_17355 antibody
  • GD17207 antibody
  • Hd6 antibody
  • HDAC antibody
  • HDAC2 antibody
  • Hdac5 antibody
  • HDAC6 antibody
  • histone deacetylase 6 antibody
  • MDC12.7 antibody
  • MDC12_7 antibody
  • MGC53140 antibody
  • mHDA2 antibody
  • RPD3B antibody
  • RTS1 antibody
  • Sfc6 antibody
  • SIL1 antibody
  • wu:fc31d02 antibody

Protein level used designations for HDAC6

CG6170-PA , CG6170-PB , CG6170-PC , CG6170-PD , CG6170-PE , CG6170-PF , CG6170-PG , HDAC6-PA , HDAC6-PB , HDAC6-PC , HDAC6-PD , HDAC6-PE , HDAC6-PF , HDAC6-PG , histone deacetylase 6 , histone deacetylase HDA2 , DsimGD17207-PA , DsimHDAC6-PA , GD17207-PA , HDAC6 , histone deacetylase 5 , histone deacetylase mHDA2 , scurfy candidate 6

32461 Drosophila melanogaster
380178 Xenopus laevis
565482 Danio rerio
6726010 Drosophila simulans
100379853 Xenopus (Silurana) tropicalis
6341259 Pyrenophora tritici-repentis Pt-1C-BFP
10013 Homo sapiens
15185 Mus musculus
84581 Rattus norvegicus
480907 Canis lupus familiaris
513602 Bos taurus
836431 Arabidopsis thaliana
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