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The protein encoded by HMMR is involved in cell motility. Additionally we are shipping HMMR Antibodies (106) and HMMR Kits (19) and many more products for this protein.
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RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules
Hyaluronon acid activation of RHAMM significantly impacts smooth muscle cell-ECM (show MMRN1 Proteins) adhesive interactions and contributes to constrictive artery wall remodeling in mice.
This study demonistrated that Rhamm expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.
Overexpressing RHAMM was located intracellular and activated ERK1/2.
Results suggest that the CD44 (show CD44 Proteins) and RHAMM receptors function on membrane lipid rafts during Cryptococcus neoformans invasion.
RHAMM isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis.
intracellular RHAMM(Delta163) functions as an adaptor protein to control microtubule polymerization during interphase and mitosis as a result of localizing ERK1/2-MEK1 (show MAP2K1 Proteins) complexes to their tubulin (show TUBB Proteins)-associated substrates
Gene deletion of Rhamm attenuates the formation of aggressive fibromatosis.
CD44 (show CD44 Proteins) and RHAMM are molecularly redundant and have roles in a model of arthritis and inflammation
Androgen receptor (show AR Proteins) regulates CD168 expression and signaling in prostate cancer
The present study suggests that RHAMM is a novel beta-catenin (show CTNNB1 Proteins) intracellular binding partner, protecting beta-catenin (show CTNNB1 Proteins) from degradation and supporting the nuclear translocation of this key cellular mediator
RHAMM expression identifies an aggressive subpopulation of tumor budding cells and is an independent adverse prognostic factor for colorectal cancer patients.
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Identify RHAMM as a critical regulator of TPX2 (show TPX2 Proteins) location/ Aurora kinase A (show AURKA Proteins) signaling and suggest that RHAMM ensures bipolar spindle assembly and mitotic progression through the integration of biochemical and structural pathways.
RHAMM might be a promising marker to identify early stage (nodal negative) patients at risk for dismal survival, who may benefit from specific adjuvant therapies.
analysis of the role of growth factors in Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis [review]
Case Report: identify patient with cervical cancer expressing three HMMR mRNA variants.
RHAMM may be implicated in severe ocular surface inflammation affecting the upper tarsal conjunctiva.
stimulation of the E2F1 (show E2F1 Proteins)-RHAMM axis in aggressive cancer cells is of high clinical significance
HMMR overexpression promotes GSC (show GSC Proteins) self-renewal.
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
hyaluronan mediated motility receptor
, intracellular hyaluronic acid-binding protein
, receptor for hyaluronan-mediated motility
, hyaluronan-mediated motility receptor