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IQGAP1 encodes a member of the IQGAP family. Additionally we are shipping IQGAP1 Antibodies (85) and and many more products for this protein.
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the present study is the first to provide evidence that miR (show MLXIP ELISA Kits)-506 acts as a tumor suppressor, at least partially, by directly downregulating IQGAP1 in breast cancer cells.
The clinical relevance of IQGAP1 as a tumor growth suppressor is supported by the finding that its expression is lower in bladder cancer compared with benign patient urothelium in multiple independent datasets.
the overexpression and interactions of IQGAP1 and beta-catenin (show CTNNB1 ELISA Kits) contribute to hepatocellular carcinoma progression by promoting cell proliferation and migration.
Down-regulation of caveolin-1 (show CAV1 ELISA Kits) or IQGAP1 in PC-3 (show PCSK1 ELISA Kits) cells reduced migration and invasion in vitro, and hypercholesterolemia-induced metastasis in vivo.
Our results identify OspB as a regulator of mTORC1 and mTORC1-dependent cell proliferation early during S. flexneri infection and establish a role for IQGAP1 in mTORC1 signaling
IQGAP1 critically mediates CXCR4 (show CXCR4 ELISA Kits) cell surface expression and signaling.
Depletion of IQGAP1 disrupts nuclear envelope localization and delays abscission timing.
IQGAP1 and its two isoforms regulate the actin-cytoskeleton alone and with their binding partners, Rac (show AKT1 ELISA Kits) and Cdc42 (show CDC42 ELISA Kits), thereby controlling diverse cellular processes, such as cell migration and adhesion. (Review)
IQGAP1 may directly interact with estrogen receptor alpha (show ESR1 ELISA Kits) and serve as a signal integrator, mediating estrogen receptor alpha (show ESR1 ELISA Kits) transcriptional activity, cell proliferation and cell invasion during the progression of thyroid cancer.
Increased IQGAP1 expression during the differentiation of cancer stem cell-like cells is involved in an aggressive cell behavior, which may contribute to metastasis of ovarian cancer.
IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.
IQGAP1 has the potential to modulate airway contraction severity in acute asthma.
we propose that IQGAP1 acts as a small GTPase (show RACGAP1 ELISA Kits) scaffolding platform within the small GTPase (show RACGAP1 ELISA Kits) network, and recruits and/or regulates small GTPases, small GTPase (show RACGAP1 ELISA Kits) regulators and effectors to orchestrate cell behavior
This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly.
IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 (show MAPK1/3 ELISA Kits) signaling protein
RSPO (show RSPO1 ELISA Kits)-LGR4 (show LGR4 ELISA Kits) not only induces the clearance of RNF43 (show RNF43 ELISA Kits)/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 ELISA Kits) signaling complex.
IQGAP1 is upregulated in pre-existed sparing neurons of the CA1 (show CA1 ELISA Kits) layer undergoing morphological changes after excitoxicity-induced hippocampal CA3 (show CA3 ELISA Kits) neuronal death.
activation of Cdc42 (show CDC42 ELISA Kits) in response to the insulin (show INS ELISA Kits) secretagogue glucose recruits endocytic machinery to IQGAP1 at the cell periphery and regulates endocytosis at this membrane site.
IQGAP1 has an essential role in RAS-driven tumorigenesis in mouse and human tissue
IQGAP1 localized to the endothelial cell-cell junction after sphingosine-1-phosphate (S1P (show S1PR1 ELISA Kits)) treatment.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
RasGAP-like with IQ motifs
, ras GTPase-activating-like protein IQGAP1
, Cdc42-Rac1 effector protein