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Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. Additionally we are shipping Insulinoma-Associated 1 Antibodies (16) and Insulinoma-Associated 1 Kits (3) and many more products for this protein.
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results reveal that IA1 constitutes a novel player downstream of Xash1 (show ASCL1 Proteins) in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons
Data supports our hypothesis that a positive-feedback loop of sonic hedgehog (show SHH Proteins) signaling induced INSM1 through N-myc (show MYCN Proteins) and INSM1 enhanced N-myc (show MYCN Proteins) stability contributing to the transformation of human neuroblastoma (show ARHGEF16 Proteins).
Small cell lung cancer tissues were strongly positive for INSM1. INSM1 signal was not detected on normal adjacent tissues from lung cancer patients or normal lung tissues
the INSM1-promoter specific conditional replicating adenovirus represents a sensitive diagnostic tool to aid clinicians in the detection of NE tumors.
Insulinoma-Associated Protein 1 is a crucial regulator of neuroendocrine differentiation in lung cancer.
INSM1 autoantibodies were associated with risk of developing type 1 diabetes.
INSM1 expression was significantly increased in Neuroendocrine neoplastic vs nonneoplastic tissue.
Both the AR42J cell line and the primary cultured mouse acinar cells support role for INSM1 in pancreatic acinar cell trans-differentiation model.
The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.
The INSM1 promoter can direct herpes simplex virus thymidine kinase (show TK1 Proteins) gene expression in a nude mouse model of neuroendocrine cancer and effectively repress tumor growth in response to ganciclovir treatment.
Data show that the consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest.
INSM1 ectopic expression impairs normal lung development especially in postnatal alveologenesis.
Insm1 is the earliest known gene expressed in outer versus inner hair cells, demonstrating that nascent outer hair cells initiate a unique differentiation program in the embryo, much earlier than previously believed.
Insm1-dependent Hes1 repression is required for neuroendocrine development.
INSM1 interacts with RACK1 (show GNB2L1 Proteins) protein and facilitates insulin receptor (show INSR Proteins) -mediated signaling.
Insm1 works to promote endocrine cell differentiation in a pathway that involves Neurog3 (show NEUROG3 Proteins) and Ripply3 (show DSCR6 Proteins)
Data suggest that IA-2 (show PTPRN Proteins) and IA-2beta (show PTPRN2 Proteins) play important roles in regulation of circadian rhythm, likely through neurochemical communication among neurons of suprachiasmatic nucleus. [Insm2 (show INSM2 Proteins)-beta; IA-2beta (show PTPRN2 Proteins); insulinoma-associated protein 2 (show INSM2 Proteins)-beta]
Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo.
This study suggested that Insm1 in promoting the transition of progenitors from apical and proliferative to basal, terminal and neuronogenic.
isolation, characterization, and identification of an interacting protein, Cbl (show CBL Proteins)-associated protein (CAP)
IA-1 gene is developmentally expressed in the nervous system and the NeuroD1 (show NEUROD1 Proteins)/E47 (show TCF3 Proteins) transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter
characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.
, insuloma-associated 1
, insulinoma-associated protein 1
, zinc finger protein IA-1
, insulinoma-associated protein (IA-1)
, insulinoma-associated 1-like protein b