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Integrin Alpha2b (CD41) ELISA Kits

ITGA2B encodes integrin alpha chain 2b. Additionally we are shipping Integrin Alpha2b Antibodies (400) and Integrin Alpha2b Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CD41 16399 Q9QUM0
CD41 3674 P08514
CD41    
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Top Integrin Alpha2b ELISA Kits at antibodies-online.com

Showing 3 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.052 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$700.00
Details
Rat 0.039 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 9 to 11 Days
$910.56
Details
Mouse 0.039 ng/ml 0.156-10 ng/mL   96 Tests Log in to see 9 to 11 Days
$910.56
Details

More ELISA Kits for Integrin Alpha2b Interaction Partners

Mouse (Murine) Integrin Alpha2b (CD41) interaction partners

  1. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.

  2. Thrombopoietin (show THPO ELISA Kits)/MPL (show MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM ELISA Kits) leukemia.

  3. Direct binding of kindlin-3 (show FERMT3 ELISA Kits) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  4. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  5. reduction of talin-beta3 integrin (show ITGB3 ELISA Kits) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding

  6. deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.

  7. Platelets lacking ERp57 (show PDIA3 ELISA Kits) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (show PDIA3 ELISA Kits), implicating surface ERp57 (show PDIA3 ELISA Kits) in platelet aggregation.

  8. Data indicate that Pyk2 (show PTK2B ELISA Kits) is a common signaling effector downstream of both G12 (show TCF3 ELISA Kits)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

  9. These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.

  10. identified Hic-5 (show TGFB1I1 ELISA Kits) as a novel and specific regulatory factor for thrombin (show F2 ELISA Kits)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.

Human Integrin Alpha2b (CD41) interaction partners

  1. Data show that immune thrombocytopenia (ITP (show ITPA ELISA Kits)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.

  2. Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb subunit.

  3. Analysis showed a protective effect of TT genotype of ITGA2 (show ITGA2 ELISA Kits) 807 C/T on fibrosis progression rate in Chronic Hepatitis C patients.

  4. Report novel ITGA2B mutations causing Glanzmann thrombasthenia.

  5. Ibrutinib causes GPVI (show GP6 ELISA Kits) and integrin alphaIIbbeta3 platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding.

  6. Data indicate 114 novel missense variants in integrin alpha 2b (ITGA2B) and 68 novel missense variants in integrin beta 3 (ITGB3 (show ITGB3 ELISA Kits)).

  7. Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa (show ITGB3 ELISA Kits) complex transmembrane/C-terminal domains and talin-1 (show TLN1 ELISA Kits) in cell membrane environment during platelet activation.

  8. Anionic lipids in annular positions stabilize the alphaIIbbeta3 transmembrane complex by up to 0.50 +/- 0.02 kcal/mol (show DUOXA1 ELISA Kits) relative to zwitterionic lipids in a headgroup structure-dependent manner.

  9. ITGA2B rs5911 GG genotype is associated with decreased ex vivo antiplatelet activity of ticagrelor in healthy Chinese male subjects.

  10. The genetic polymorphism of GP lIb-Illa (GP Ila (show TNFRSF9 ELISA Kits) Leu33Pro) was not noted to affect platelet aggregation.

Integrin Alpha2b (CD41) Antigen Profile

Antigen Summary

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene names and symbols associated with Integrin Alpha2b (CD41) ELISA Kits

  • integrin alpha 2b (Itga2b) antibody
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) antibody
  • AI172977 antibody
  • alphaIIb antibody
  • BDPLT2 antibody
  • BDPLT16 antibody
  • CD41 antibody
  • CD41B antibody
  • GP2B antibody
  • GPIIb antibody
  • GT antibody
  • GTA antibody
  • HPA3 antibody

Protein level used designations for Integrin Alpha2b (CD41) ELISA Kits

GP IIb , GPalpha IIb , alpha IIb , integrin alpha-IIb , platelet glycoprotein IIb of IIb/II Ia complex , platelet membrane glycoprotein IIb , platelet fibrinogen receptor, alpha subunit , platelet-specific antigen BAK

GENE ID SPECIES
16399 Mus musculus
3674 Homo sapiens
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