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The protein encoded by IL37 is a member of the interleukin 1 cytokine family. Additionally we are shipping Interleukin 37 Proteins (18) and Interleukin 37 Kits (17) and many more products for this protein.
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These fi ndings suggest that elevation of HLA-G (show HLAG Antibodies) and IL-37 in hepatitis C virus may play an important role in response to combined therapy with interferon (show IFNA Antibodies)-apha and ribovirin.
These results demonstrated that IL-37 might manifest as a critical protein involving in immunosuppression of human CD4 (show CD4 Antibodies)(+)CD25 (show IL2RA Antibodies)(+)Tregs.
The expression of IL-37 was decreased in renal cell carcinoma (show MOK Antibodies) patients and was negatively correlated with tumor progression.
tubular epithelial cells express the IL-18 contra-regulatory protein IL-37 as an endogenous control mechanism to reduce inflammation
research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 (show MAPK1/3 Antibodies) and p38 MAPK (show MAPK14 Antibodies) pathways.
The results suggest serum IL-37 levels were increased in rheumatoid arthritis (RA) patients and were positively associated with disease activity, IL-17 (show IL17A Antibodies)/IL-23 (show IL23A Antibodies) and bone loss in RA, suggesting that IL-37 may play a critical role in the pathogenesis of RA.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
, IL-1 zeta
, IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
, IL-1X protein
, IL1F7 (canonical product IL-1F7b)
, interleukin 1 family member 7
, interleukin 1, zeta
, interleukin-1 homolog 4
, interleukin-1 superfamily z
, interleukin-1-related protein