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Cytokine with a wide variety of biological functions.
the results of the present study strongly suggest that mimosine, a normoxic inducer of HIF, inhibits the PGF2ainduced osteoprotegerin (show TNFRSF11B Antibodies) synthesis without affecting the IL-6 synthesis in osteoblasts
IL-6 signaling in dendritic cells is essential for their uptake of allergens, maturation, and initiation of Th2/Th17-mediated airway inflammation and airway hyper-reactivity in asthma
IL-6/gp130 (show LRPPRC Antibodies) signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
IL6-controlled accumulation of decidual CD4(+) T cells and CD8(+) regulatory T cells, with an associated decline in decidual Th9 cells, is instrumental for progressing parturition in mice.
Skeletal muscle IL-6 regulates hepatic glucose metabolism during high fat diet combined with exercise training.
IL-33 (show IL33 Antibodies) promotes degranulation of bone marrow-derived mast cells and release of cytokines IL-1beta (show IL1B Antibodies), IL-6 and TNF-alpha (show TNF Antibodies).
These data suggest a new paradigm for the regulation of megakaryocytopoiesis and platelet production via a synergistic effect of LPS (show TLR4 Antibodies) and IL-6.
exercise increases IL-6 signaling in a depot-dependent manner, likely through an autocrine/paracrine mechanism
LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta (show IFNB1 Antibodies)) and interleukin-6 (IL-6).
CCR5 (show CCR5 Antibodies) blockade suppresses B16 melanoma growth by inhibiting of IL-6-Stat3 (show STAT3 Antibodies) signaling pathway via upregulation of SOCS3 (show SOCS3 Antibodies).
The GG genotype of the -634C/G polymorphism in IL-6 appears to play a role in reducing bone mineral density, which affects normal bone metabolism and leads to osteoporosis. (Meta-analysis)
Administration of E1 + P1 and E1 + P2 decreased the inhibitory effect of E1 on the IL-6 levels and AQP4 (show AQP4 Antibodies) protein expression
The present study therefore indicated that IL-6 promoted the process of EMT (show ITK Antibodies) in HIBECs as characterized by increased migration and invasion of HIBECs and the typical changes in mRNA and protein expression of the EMT (show ITK Antibodies) markers E-cadherin (show CDH1 Antibodies) and vimentin (show VIM Antibodies).
Our data suggested that IL-6 mediates the singnal pathway of JAK (show JAK3 Antibodies)-STAT3 (show STAT3 Antibodies)-VEGF-C (show VEGFC Antibodies) promoting the growth, invasion and lymphangiogenesis in gastric cancer
Combination of maternal characteristics and maternal serum IL-6 levels may provide effective first trimester screening for gestational diabetes mellitus.
Data suggest that overweight interacts with vitamin D deficiency to modulate inflammatory response, affecting plasma levels of adiponectin (show ADIPOQ Antibodies), sICAM1 (soluble intercellular adhesion molecule-1 (show ICAM1 Antibodies)), and cytokines (interleukin 6, tumor necrosis factor-alpha (show TNF Antibodies)).
IL6 increased significantly during short-term normobaric hypoxia.
Il-6 CC genotype was more strongly associated with ischemic stroke than other two polymorphisms TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies) in our population.
we found no trend of increasing risk for primary dysmenorrhea in association with the number of putative high-risk genotypes of IL6 gene -597 G>A and -572 G>C and ESR1 (show ESR1 Antibodies) gene XbaI polymorphisms.
Cerebrospinal fluid (CSF (show CSF2 Antibodies)) levels of IL-6, IL-8 (show IL8 Antibodies), IL-10 (show IL10 Antibodies), MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies) were significantly higher in patients with acute transverse myelitis; CSF (show CSF2 Antibodies) IL-6 and IL-8 (show IL8 Antibodies) were significantly associated with severity of the disease
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Testicular IL-1 alpha (show IL1A Antibodies) and IL-1 beta (show IL1B Antibodies) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Antibodies) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Antibodies), iNOS (show NOS2 Antibodies), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Antibodies) was unaffected.[IL-6, IL-12 (show IL12A Antibodies)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Antibodies) and IL-6/sIL (show STIL Antibodies)-6R in causing proteoglycan (show Vcan Antibodies) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Antibodies) and IL-6 in rabbit cornea cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Antibodies), IL-10 (show IL10 Antibodies), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Antibodies) (signal transducer/activator of transcription (show STAT1 Antibodies) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Antibodies) expression/phosphorylation).
LIF (show LIF Antibodies) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (show EDN1 Antibodies), and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL (show BCL2L1 Antibodies) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP (show BNC2 Antibodies), ICAM-1 (show ICAM1 Antibodies), TNF-alpha (show TNF Antibodies), VCAM-1 (show VCAM1 Antibodies) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.
role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Antibodies) signaling pathway transactivator beta-catenin (show CTNNB1 Antibodies), induced expression of inhibitors of the Wnt (show WNT2 Antibodies) pathway, and increased expression of GDF-5 (show GDF5 Antibodies).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Antibodies) activation and that this effect can be modulated by A2AAR (show ADORA2A Antibodies)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Antibodies) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Antibodies) and TNF-alpha (show TNF Antibodies), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Antibodies)), are potent inducers of IL-1beta (show IL1B Antibodies) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Antibodies).
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity).