Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Cytokine with a wide variety of biological functions.
IL-33 (show IL33 Antibodies) promotes degranulation of bone marrow-derived mast cells and release of cytokines IL-1beta (show IL1B Antibodies), IL-6 and TNF-alpha (show TNF Antibodies).
These data suggest a new paradigm for the regulation of megakaryocytopoiesis and platelet production via a synergistic effect of LPS (show TLR4 Antibodies) and IL-6.
exercise increases IL-6 signaling in a depot-dependent manner, likely through an autocrine/paracrine mechanism
LH gels incorporating cGAMP (LH/cGAMP gels) elicited excellent induction of the cytokines interferon-beta (IFN-beta (show IFNB1 Antibodies)) and interleukin-6 (IL-6).
CCR5 (show CCR5 Antibodies) blockade suppresses B16 melanoma growth by inhibiting of IL-6-Stat3 (show STAT3 Antibodies) signaling pathway via upregulation of SOCS3 (show SOCS3 Antibodies).
IL-6 inhibits the apoptosis of exocrine gland tissues and exerts a tissue-protective effect under inflammatory conditions including Sjogren's syndrome
findings suggest that high-level production of IL6 by B cells induced by integrated signaling from the IFN1 receptor, TLR7 (show TLR7 Antibodies) and BCR (show BCR Antibodies) promotes the differentiation of IL21 (show IL21 Antibodies)-secreting CD4 (show CD4 Antibodies)-positive follicular helper cells
findings identify a previously unrecognized role for NFkappaB1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells.
peripheral and central nervous interleukin-6 (IL-6) trans-signaling differentially influences brain activity. Peripheral IL-6 trans-signaling appears to more profoundly contribute to sleep regulation, mainly by supporting slow wave sleep.
genetic ablation of Rac1 in the myeloid lineage protected against LPS (show TLR4 Antibodies)-induced renal inflammation and injury, by suppressing macrophage-derived cytokines, IL-6 and TNFalpha (show TNF Antibodies), without blocking recruitment
Data indicate that better cognitive control specifically following an emotional stressor is uniquely associated with less pronounced salivary IL-6 increase in response to such stress.
pimozide reduced the basal expression of phosphorylation STAT3 (show STAT3 Antibodies) at tyrosine 705 and reversed the expression of phosphorylation of STAT3 (show STAT3 Antibodies) induced by IL-6 addition, suggesting that pimozide can suppress cellular STAT3 (show STAT3 Antibodies) activation
Our data suggest that chronic inflammation promotes the development of CRC (show CALR Antibodies) by stimulating aerobic glycolysis and IL-6 is functioning, at least partly, through regulating PFKFB3 (show PFKFB3 Antibodies) at early stage of colorectal cancer (CRC (show CALR Antibodies)).
Interleukin-6 measured by electrochemiluminescence method is a promising marker for early differentiation between aseptic and bacterial meningitis
Study reports that miR (show MLXIP Antibodies)-9 is down-regulated in cervical adenocarcinoma due to its frequent promoter-hypermethylation and exerts its tumor suppressor role through inhibiting several novel target genes, including interleukin-6 (IL-6).
Data indicate the role of tropomyosin-related kinase-B (TrkB (show NTRK2 Antibodies)) in activation of the interleukin-6/Janus kinase 2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) transcription factor and PI3 kinase (show PIK3CA Antibodies)/c-AKT (show AKT1 Antibodies) proto-oncogene (show RAB1A Antibodies) protein pathway in breast cancer.
Up-regulation of IL-6 is associated with triple-negative breast cancer.
The meta-analysis provides evidence of the association between the IL-6 polymorphism and the risk of SLE, hinting that the IL-6-174 G/C and IL-6-572 G/C polymorphisms may play a role in SLE susceptibility. [meta-analysis]
Data show that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of proinflammatory cytokines CXCL-8 (show IL8 Antibodies), IL-6 and MCP-1 (show CCL2 Antibodies).
the results of this meta-analysis suggested that the IL-6 -572G/C polymorphism was not associated with an elevated risk of cancer.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Testicular IL-1 alpha (show IL1A Antibodies) and IL-1 beta (show IL1B Antibodies) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Antibodies) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Antibodies), iNOS (show NOS2 Antibodies), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Antibodies) was unaffected.[IL-6, IL-12 (show IL12A Antibodies)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Antibodies) and IL-6/sIL (show STIL Antibodies)-6R in causing proteoglycan (show Vcan Antibodies) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Antibodies) and IL-6 in rabbit cornea cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Antibodies), IL-10 (show IL10 Antibodies), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Antibodies) (signal transducer/activator of transcription (show STAT1 Antibodies) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Antibodies) expression/phosphorylation).
LIF (show LIF Antibodies) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (show EDN1 Antibodies), and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL (show BCL2L1 Antibodies) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP (show BNC2 Antibodies), ICAM-1 (show ICAM1 Antibodies), TNF-alpha (show TNF Antibodies), VCAM-1 (show VCAM1 Antibodies) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.
role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Antibodies) signaling pathway transactivator beta-catenin (show CTNNB1 Antibodies), induced expression of inhibitors of the Wnt (show WNT2 Antibodies) pathway, and increased expression of GDF-5 (show GDF5 Antibodies).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Antibodies) activation and that this effect can be modulated by A2AAR (show ADORA2A Antibodies)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Antibodies) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Antibodies) and TNF-alpha (show TNF Antibodies), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Antibodies)), are potent inducers of IL-1beta (show IL1B Antibodies) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Antibodies).
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity).