Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Cytokine with a wide variety of biological functions.
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 trans-signaling.
Blocking IL-6 trans-signaling in the CNS abrogates the ability of IL-6 to suppress feeding. Furthermore, gp130 (show LRPPRC Antibodies) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (show LRPPRC Antibodies) in the PVH attenuates the beneficial central IL-6 effects on metabolism
We conclude that upon ligand binding, TLR4 (show TLR4 Antibodies) activates PI3K/Akt (show AKT1 Antibodies) signaling to induce F-spondin (show SPON1 Antibodies) expression, subsequently control CREB (show CREB1 Antibodies)-mediated IL-6 production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin (show SPON1 Antibodies) in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis.
The mechanosensitive up-regulation and release of cytokine IL-6 from the retina involves the P2X7 receptor (show P2RX7 Antibodies), with both astrocytes and neurons contributing to the response
his study shows that Mir (show MLXIP Antibodies)-26a attenuates the development of non-alcoholic fatty liver disease by inhibiting the expression of IL-17 (show IL17A Antibodies) and IL-6
These results strongly suggest that incretins upregulate the TNF-alpha-stimulated IL6 synthesis in osteoblasts, and that the amplifying effect of incretin is exerted via reducing the IkappaB/NFkappaB pathway through the adenylyl cyclase-cAMP system.
Genetic deletion of IL-6 attenuates left ventricle hypertrophy and dysfunction.
In this study we have demonstrated that IL-6 is one of the mediating factors that contributes to the development of cardiac infarct size during the early period (<1 (show PER1 Antibodies) day) of reperfusion, following an injurious period of cardiac ischemia in the absence of surgical stress
this study shows that downregulation of IL-6 in dendritic cells by paeoniflorin is mediated via upregulation of Socs3 (show SOCS3 Antibodies)
provided evidences that IL-6 over-secretion impaired osteogenesis of osteoporotic bone marrow stromal cells
NKX6.1 (show NKX6-1 Antibodies) is a factor for IL-6-regulated growth and tumor formation in basal-like breast cancer.
The combination of IL-6 and IL-1beta (show IL1B Antibodies) at concentrations associated with percutaneous coronary intervention cannot induce CRP (show CRP Antibodies) expression in human vascular smooth muscle cells, but they can augment mechanical strain-induced CRP (show CRP Antibodies) synthesis via the stretch activated channel-NF-kappaB (show NFKB1 Antibodies) pathway.
We found no evidence that the TNF-alpha (show TNF Antibodies) G308A and IL-6 G174C SNPs affected the probability of reaching an advanced age in Caucasians, and that they have little effect on delaying the onset and progression of age-related diseases, but this does not rule out the possibility of population-specific effects caused by different genes and/or environmental factors and their interactions.
MALAT1 suppressed LPS (show IRF6 Antibodies)-induced mRNA accumulation of TNFa (show TNF Antibodies) and IL-6 without suppressing IL-1beta (show IL1B Antibodies) mRNA production. abnormal expression of MALAT1 was found to be NF-kappaB (show NFKB1 Antibodies)-dependent
Taken together, these findings suggested that E2 inhibited the proliferation of AR HCC (show FAM126A Antibodies) cells through down-regulation of IL-6/STAT3 (show STAT3 Antibodies) signaling. Thus, E2 can be a potential therapeutic drug for treatment of metastatic or chemo-resistant HCC (show FAM126A Antibodies).
IL-6 (-174) G/C polymorphism and serum IL-6 levels may be associated with the severity of NTG (show OPA1 Antibodies)
High IL-6 expression is associated with obesity.
Our results showed that 3 single nucleotide polymorphisms of ACE rs4340, IL-6 rs1800795, and NOS3 rs1799983 were significantly associated with the risks of mycoplasma pneumoniae pneumonia (MPP), while no differences were observed in genotype frequencies of GSTM1 and CYP1A1. The combinations of ACE/NOS3/CYP1A1 and ACE /NOS3 contribute to the genetic susceptibility of MPP in Chinese children.
PCT (show UROD Antibodies) may be considered a good predictor of adverse renal outcome in cardiac surgery patients, whereas IL-6 seems to possess a good predictive value for mortality in this population of patients.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Testicular IL-1 alpha (show IL1A Antibodies) and IL-1 beta (show IL1B Antibodies) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Antibodies) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (show TNF Antibodies), iNOS (show NOS2 Antibodies), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Antibodies) was unaffected.[IL-6, IL-12 (show IL12A Antibodies)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Antibodies) (sIL (show STIL Antibodies)-6R), induces activation of JAK1 (show JAK1 Antibodies), JAK2 (show JAK2 Antibodies), and STAT1 (show STAT1 Antibodies)/STAT3 (show STAT3 Antibodies) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Antibodies) and IL-6/sIL (show STIL Antibodies)-6R in causing proteoglycan (show Vcan Antibodies) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Antibodies) and IL-6 in rabbit cornea cells.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (show HIF1A Antibodies)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Antibodies), IL-10 (show IL10 Antibodies), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Antibodies) (signal transducer/activator of transcription (show STAT1 Antibodies) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Antibodies) expression/phosphorylation).
LIF (show LIF Antibodies) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (show EDN1 Antibodies), and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL (show BCL2L1 Antibodies) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP (show BNC2 Antibodies), ICAM-1 (show ICAM1 Antibodies), TNF-alpha (show TNF Antibodies), VCAM-1 (show VCAM1 Antibodies) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (show TNF Antibodies) and IL-10 (show IL10 Antibodies), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Antibodies) signaling pathway transactivator beta-catenin (show CTNNB1 Antibodies), induced expression of inhibitors of the Wnt (show WNT2 Antibodies) pathway, and increased expression of GDF-5 (show GDF5 Antibodies).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Antibodies) activation and that this effect can be modulated by A2AAR (show ADORA2A Antibodies)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Antibodies) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Antibodies) and TNF-alpha (show TNF Antibodies), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Antibodies)), are potent inducers of IL-1beta (show IL1B Antibodies) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Antibodies).
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity).