Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) ELISA Kits

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Antibodies (205) and IDH1 Proteins (16) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top IDH1 ELISA Kits at antibodies-online.com

Showing 7 out of 20 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.33 ng/mL 0.78-50 ng/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Rat 0.116 ng/mL 0.312-20 ng/mL 96 Tests Log in to see 15 to 17 Days
$973.11
Details
Human 0.31 ng/mL 0.78-50 ng/mL   96 Tests Log in to see 2 to 3 Days
$658.90
Details
Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Pig
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details
Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details
Human
0.69-500 ng/mL   96 Tests Log in to see 11 to 18 Days
$1,079.38
Details

Top referenced IDH1 ELISA Kits

  1. Human IDH1 ELISA Kit for Sandwich ELISA - ABIN423443 : Tan, Jiang, Sun, Chen, Lv, Shao, Li, Qiu, Gao, Li, Tan, Zhou, Wang, Ding, Wang, Sun, Hang, Shi, Feng, He, He: Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis. in Molecular & cellular proteomics : MCP 2012 (PubMed)
    Show all 3 references for 423443

More ELISA Kits for IDH1 Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. The data of this study suggested that mutant IDH1 has potent antithrombotic activity within gliomas and throughout the peripheral circulation.

  2. This retrospective analysis suggested that the presence of an IDH1 (R132H) mutation, frontal tumor location, and WHO grade of the initial tumor are associated with OS after progression to secondary glioblastoma.

  3. Expression of mutant IDH1 suppresses the accumulation of T cells in glioma tumor sites.

  4. Study describes the development of a highly specific and first potent pan-inhibitor of all IDH1R132 mutations (BAY 1436032) with favorable pharmacological and pharmacokinetic properties.

  5. Results showed that TERT promoter mutational status combined with IDH-mutation allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.

  6. the mutant IDH1 protein is a stronger oncogene (show RAB1A ELISA Kits) than R-2HG alone when comparable intracellular R-2HG levels are achieved

  7. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM (show ATM ELISA Kits) by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (show FUT1 ELISA Kits) self-renewal, independent of TET2 (show TET2 ELISA Kits).

  8. Patients with Isocitrate dehydrogenase 1 (IDH1) wildtype show reduced neurocognitive function (NCF (show NCF4 ELISA Kits)) compared with those with IDH1-mutant malignant gliomas. Lesion volume is inversely associated with NCF (show NCF4 ELISA Kits) for patients with IDH1-WT, but not IDH1-M tumors.

  9. prevalence of IDH-mutant gliomas in older persons; from 578 total gliomas tested, 88 were IDH-mutant DA/AA/GBMs and 11 IDH-mutant tumors were in persons age 55 and older; of the 11 IDH-mutant examples in the older group, 9 were first clinical presentations of the tumor, 4 of which were in persons age 70 or older

  10. Studies confirm that mutant IDH1 is a driver of gliomagenesis and further show that mutant IDH1-driven gliomagenesis can occur more rapidly than previously appreciated.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  2. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM (show ATM ELISA Kits) by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (show FUT1 ELISA Kits) self-renewal, independent of TET2 (show TET2 ELISA Kits).

  3. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (show ACO1 ELISA Kits), enzymes involved in the TCA cycle, were elevated.

  4. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  5. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH (show FDXR ELISA Kits) ratio.

  6. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  7. MiR (show MLXIP ELISA Kits)-181a regulates lipid metabolism via IDH1

  8. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  9. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

  10. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B ELISA Kits)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B ELISA Kits)

  3. These results suggest that IDPm (show IDH2 ELISA Kits) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 ELISA Kits) activity.

IDH1 Antigen Profile

Antigen Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1) antibody
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) antibody
  • AI314845 antibody
  • AI788952 antibody
  • cb876 antibody
  • E030024J03Rik antibody
  • fm90e09 antibody
  • Id-1 antibody
  • IDCD antibody
  • IDH antibody
  • Idh-1 antibody
  • IDP antibody
  • Idpc antibody
  • im:7143416 antibody
  • NADP-CICDH antibody
  • PICD antibody
  • wu:fm90e09 antibody

Protein level used designations for IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPECIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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