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Plays a central role in hair and nail formation. Additionally we are shipping Keratin 75 Antibodies (52) and Keratin 75 Kits (1) and many more products for this protein.
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Studies show that mutation in epithelial hair keratin KRT75 leads to a skin condition called pseudofollicularis barbae. Carriers of this mutation have an altered enamel structure and mechanical properties leading to much higher prevalence of caries. [review]
The expression of CK5 (show KRT5 Proteins)/6 and of P63 (show RPE65 Proteins) suggests a squamous differentiation including in the basaloid thyroid lymphoepithelial complexes
CK5 (show KRT5 Proteins)/6 have roles in biologically aggressive tumors likely to display resistance to trastuzumab ab initio in women diagnosed with HER2 (show ERBB2 Proteins)+ cancer
There were differences between CK5 (show KRT5 Proteins)/6, p63 (show RPE65 Proteins),CK34betaE12 and TTF-1 (show NKX2-1 Proteins) expression with tumor differentiation in squamous cell carcinoma or adenocarcinomas
Analysis of teeth from individuals carrying the KRT75(A161T) variant revealed an altered enamel structure and a marked reduction of enamel hardness, suggesting that a functional keratin network is required for the mechanical stability of tooth enamel.
we observed a possible association between CK5 (show KRT5 Proteins)/6 expression in the primary tumor and multiple versus solitary breast carcinoma brain metastasis
K75 expression is closely associated with the process of desquamation of the inner root sheath of hair follicles.
Cytokeratin 5 (show KRT5 Proteins)/6 can be a useful adjunct in cases with ductal hyperplasia but not in columnar cell lesions, on breast core biopsies
Positive staining for CK5 (show KRT5 Proteins)/6 or CK17 (show KRT17 Proteins) was associated with a worse prognosis, high tumor grade and positive axillary lymph nodes.
mK6a (show KRT6A Proteins) and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen.
Mice expressing mutant form of Krt75 developed hair and nail (show CD244 Proteins) defects resembling pachyonychia congenita
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
cytokeratin type II
, type II alpha-keratin IIB
, keratin 75
, keratin, type II cytoskeletal 75
, keratin-6 hair follicle
, type II keratin-18
, type II keratin-K6hf
, type-II keratin Kb18
, cytokeratin KRT2-6HF
, keratinocyte associated protein 1
, type II keratin Kb18