Kruppel-Like Factor 1 (erythroid) Proteins (KLF1)

KLF1 encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. Additionally we are shipping KLF1 Antibodies (90) and KLF1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLF1 10661 Q13351
KLF1 16596  
Rat KLF1 KLF1 304666  
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Top KLF1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$205.80
Details

KLF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Kruppel-Like Factor 1 (erythroid) (KLF1) Interaction Partners

Human Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR

  2. Introduction of the British HPFH mutation into the fetal globin promoter in a human cell model causes elevated fetal globin expression. The British HPFH mutation creates a de novo binding site both in vitro and in vivo for the potent erythroid activator KLF1.

  3. A hypothesis on possible liaisons between mutations in the gene encoding EKLF and resistance to pathogens is presented.

  4. study reports a novel KLF1 mutation codon 211 A-->G (c.632 A>G) in a family with beta-hemoglobinopathy showing a considerable increase in the HbF level, thus supporting the role of KLF1 in hemoglobin switching

  5. seven new alleles in the KLF1 gene, which are presumed to act dominantly to silence LU expression, were identified

  6. The prevalence of the In(Lu) phenotype in the Japanese population was 0.02%, and we identified 13 known and 21 novel KLF1 alleles. The KLF1 mutations cause the reduced expression of the P1 antigen.

  7. Our study highlighted two novel promoter KLF1 and 3'-region C/EBPalpha motifs in the phenylalanine hydroxylase (PAH) gene which decrease transcription in vitro and, thus, could be considered as PAH expression modifiers.

  8. a broad range of hitherto unrelated human red cell disorders are caused by variants in KLF1, a master regulator of erythropoiesis, which were previously considered to be extremely rare causes of human genetic disease [review]

  9. results suggest that KLF1 directly regulates the beta-globin gene, but probably has less direct impact on expression of the gamma-globin gene in fetal erythroblasts

  10. A KLF1-targeted promoter-reporter assay showed that the two mutations reduce the expression of the HBB, BCL11A (show BCL11A Proteins), and CD44 (show CD44 Proteins) genes involved in erythropoiesis.

Mouse (Murine) Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. The semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter correct development in the early embryo.

  2. Point mutations in the erythroid transcription factor, Klf1: one mutation, D11 generates a stop codon in the zinc finger domain and a homozygous null phenotype; another mutation, D45, generates an amino acid transversion (H350R) within a linker between zinc fingers two and three.

  3. Data indicate that PIAS3 (protein inhibitor of activated STAT3 (show PIAS3 Proteins)) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner.

  4. Hemin-induced expression of PlGF (show PGF Proteins) is abolished in EKLF-deficient erythroid cells but rescued by conditional expression of EKLF.

  5. HIRA (show HIRA Proteins) is not only critical for beta-globin (show HBB Proteins) expression but is also required for activation of the erythropoietic regulators EKLF and GATA binding protein 1 (GATA1).

  6. KLF1 and KLF2 (show KLF2 Proteins) coordinately regulate embryonic erythroid precursor maturation through the regulation of multiple homeostasis-associated genes.

  7. EKLF mRNA has exon skipping only in primary tissues. The splice variant is at a low level in embryonic and adult erythroid cells, and in terminal differentiation. The truncated protein partially encodes a non-erythroid Kruppel-like factor AA sequence.

  8. Dok2 is able to control Klf1 expression by transcriptional regulation through directly binding to its promoter region.

  9. EKLF plays a coordinating role between two different cell types whose interaction provides the optimal environment to generate a mature red blood cell

  10. the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors

KLF1 Protein Profile

Protein Summary

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.

Gene names and symbols associated with KLF1

  • Kruppel-like factor 1 (erythroid) (KLF1)
  • Kruppel-like factor 1 (erythroid) (Klf1)
  • Eklf protein
  • HBFQTL6 protein
  • INLU protein
  • KLF1 protein
  • Nan protein

Protein level used designations for KLF1

Kruppel-like factor 1 (erythroid) , Krueppel-like factor 1 , erythroid Kruppel-like factor , erythroid krueppel-like transcription factor , erythroid-specific transcription factor EKLF , monoclonal antibody A3D8 , erythroid transcription factor , neonatal anemia

GENE ID SPECIES
424577 Gallus gallus
468741 Pan troglodytes
100599870 Nomascus leucogenys
10661 Homo sapiens
100174958 Sus scrofa
784295 Bos taurus
16596 Mus musculus
304666 Rattus norvegicus
484924 Canis lupus familiaris
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