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LASP1 encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Additionally we are shipping LASP1 Antibodies (109) and LASP1 Proteins (13) and many more products for this protein.
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LASP-1 may essentially involve in the metastasis and growth of CCA (show FBN2 ELISA Kits) and clinical significance of LASP-1 may reside in function as a biomarker to predict prognosis and as a promising therapeutic strategy for CCA (show FBN2 ELISA Kits) patients by the inhibition of LASP-1 expression
It is a target gene of miR-1.
LASP-1 associated with UHRF1 (show UHRF1 ELISA Kits), G9a (show EHMT2 ELISA Kits), Snail1 (show SNAI1 ELISA Kits) and di- and tri (show VANGL2 ELISA Kits)-methylated histoneH3 in a CXCL12 (show CXCL12 ELISA Kits)-dependent manner based on immunoprecipitation and proximity ligation assays
LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P (show S100P ELISA Kits) via the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) pathway.
LASP-1, mediated by miR (show MLXIP ELISA Kits)-203, has crucial functions in the proliferation, migration and invasion of human non-small cell lung cancer
Detecting an affection of migratory processes after LASP-1 silencing, we propose that LASP-1 could impact on metastasis of CC [choriocarcinoma]cells.
Results identified LASP1 as a hitherto unknown protein in melanocytes and as novel partner of dynamin (show DNM1 ELISA Kits) in the physiological process of membrane constriction and melanosome vesicle release.
Our results suggest that LASP-1 mRNA overexpression may be mainly implicated in female hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) and cirrhotic HCCs (show HCCS ELISA Kits); and that LASP1 may play its role with vimentin (show VIM ELISA Kits) in HCC (show FAM126A ELISA Kits) cells.
LASP-1 overexpression was associated with aggressive phenotype in clear cell renal cell cancer.
LASP1 plays key roles in cell structure, physiological processes, and cell signaling; overexpression contributes to cancer aggressiveness [review]
Results defined LASP1 as a direct target gene for HIF1alpha (show HIF1A ELISA Kits) upregulation that is critical for metastatic progression of PDAC.
Data show that MEFs derived from Lasp1(-/-) mice migrated more rapidly in vitro.
LIM-nebulette (show NEBL ELISA Kits), Lasp-1, and zyxin (show ZYX ELISA Kits) may play an important role in the organization of focal adhesions
Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM (show MMRN1 ELISA Kits) proteins.
Data suggest that there are no functional differences between human and mouse LASP-1.
The role of Lasp1 in the regulation of hydrochloride secretion in vivo was studied in a murine model with a targeted disruption of the Lasp-1 gene.
role of Lasp1 in chondrocyte differentiation during cartilage to bone transition
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
LIM and SH3 domain protein 1
, LIM and SH3 protein 1
, lasp1 protein
, metastatic lymph node gene 50 protein
, MLN 50
, 40 kDa phosphoprotein
, phosphoprotein Lasp-1