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LGALS9 was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. Additionally we are shipping Lectin, Galactoside-Binding, Soluble, 9 Kits (52) and Lectin, Galactoside-Binding, Soluble, 9 Proteins (37) and many more products for this protein.
Showing 10 out of 188 products:
Mouse (Murine) Monoclonal LGALS9 Primary Antibody for FACS - ABIN2657895
Dunphy, Barcham, Bischof, Young, Nash, Meeusen: Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge. in The Journal of biological chemistry 2002
Show all 6 references for 2657895
Mouse (Murine) Monoclonal LGALS9 Primary Antibody for FACS - ABIN2658314
Tsuboi, Abe, Nakagawa, Oomizu, Watanabe, Nishi, Nakamura, Yamauchi, Hirashima: Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. in Clinical immunology (Orlando, Fla.) 2007
Show all 6 references for 2658314
Human Monoclonal LGALS9 Primary Antibody for ELISA (Capture), FACS - ABIN1449219
Yanai, Saito, Kakinuma, Kon, Hirota, Taniguchi-Yanai, Nishijo, Shigematsu, Horiguchi, Kasuya, Sugiyama, Yagami, Murakami, Fukamizu: Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. in The Journal of biological chemistry 2000
Show all 5 references for 1449219
Human Polyclonal LGALS9 Primary Antibody for EIA, WB - ABIN952439
Dardalhon, Anderson, Karman, Apetoh, Chandwaskar, Lee, Cornejo, Nishi, Yamauchi, Quintana, Sobel, Hirashima, Kuchroo: Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Monoclonal LGALS9 Primary Antibody for FACS - ABIN1449220
Lipkowitz, Leal-Pinto, Cohen, Abramson: Galectin 9 is the sugar-regulated urate transporter/channel UAT. in Glycoconjugate journal 2004
Show all 3 references for 1449220
Mouse (Murine) Polyclonal LGALS9 Primary Antibody for FACS, ICC - ABIN4899254
Iqbal, Sampaio, Maione, Greco, Niki, Hirashima, Perretti, Cooper: Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect. in The American journal of pathology 2011
Cow (Bovine) Polyclonal LGALS9 Primary Antibody for WB - ABIN2785903
Bi, Earl, Jacobs, Baum: Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways. in The Journal of biological chemistry 2008
Galectin 9 is a novel dectin 1 (show CLEC7A Antibodies) ligand in pancreatic ductal adenocarcinoma. Upon disruption of the dectin 1 (show CLEC7A Antibodies)-galectin 9 axis, CD4 (show CD4 Antibodies)(+) and CD8 (show CD8A Antibodies)(+) T cells, which are dispensable for PDA progression in hosts with an intact signaling axis, become reprogrammed into indispensable mediators of anti-tumor immunity.
The Gal-9/Tim-3 (show HAVCR2 Antibodies) signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
These results indicate the possibility that cooperative binding of oligosaccharide and neighboring polypeptide structures of monoclonal IgE to galectin-9 affects the overall affinity and specificity of the IgE-lectin interaction.
galectin-9 functions as a novel alarmin by augmenting the inflammatory response in sepsis development during pulmonary F. novicida infection.
Gal-9 has a role in the maintenance of hepatic homeostasis and preventing liver ischemia-reperfusion injury
Gal-9, a natural TIM-3 (show HAVCR2 Antibodies) ligand, was produced primarily by and released from ischemia-reperfusion-stressed hepatocytes, both in vivo and in vitro.
Galectin-9 functions as an astrocyte-microglia communication signal and promotes cytokine production from microglia in a Tim-3 (show HAVCR2 Antibodies) independent manner.
galectin-9, in addition to being an effector molecule for regulatory T cells cells, acts synergistically with TGF-beta (show TGFB1 Antibodies) to enforce iTreg cell differentiation and maintenance.
Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.
action of agonist anti-4-1BB (show TNFRSF9 Antibodies) in suppressing autoimmune and allergic inflammation was completely dependent on Galectin-9 (Gal-9). Gal-9 directly bound to 4-1BB (show TNFRSF9 Antibodies), in a site distinct from the binding site of antibodies and the natural ligand of 4-1BB (show TNFRSF9 Antibodies)
X-ray structure of a protease-resistant mutant form of human galectin-9 having two carbohydrate recognition domains with a metal-binding site has been presented.
These findings may indicate that an increase in the Gal-9 level, a novel immune checkpoint molecule, can reflect immune-related adverse effects of various biotherapies.
Our data suggest a role of galectin-9 in regulating HIV transcription and viral production in vivo during therapy
these data suggest that the high Tim-3 (show HAVCR2 Antibodies) expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4 (show CD4 Antibodies)(+) T cells
this study shows that in osteosarcoma patients, Tim3 (show HAVCR2 Antibodies) expression did not directly mediate immune suppression, but the interaction between Tim3 (show HAVCR2 Antibodies)+ T cells and monocytes, naive CD4 (show CD4 Antibodies)+ T cells, and Gal9-expressing CD4 (show CD4 Antibodies)+ CD25 (show IL2RA Antibodies)+ Tregs could resulting in progressive suppression of Th1 (show TH1L Antibodies) responses
The human recombinant galectin-9 has demonstrated anti-cancer activities, including inducing apoptosis in hematological, dermatological and gastrointestinal malignancies. In this review, the molecular characteristics, history and apoptosis-inducing potential of galectin-9 are described. [review]
Results showed that in acute febrile phase, galectin-9 and galectin-3BP were induced in dengue patients compared to healthy controls suggesting that both molecules might be important inflammatory mediators in acute dengue virus infection.
In this review, we summarize the latest knowledge on the structure, receptors, cellular targets, trafficking pathways and functional properties of galectin-9 and discuss how galectin-9-mediated signalling cascades can be exploited in cancers and immunotherapies
this study shows that the levels of expression of Gal-9 on CD4 (show CD4 Antibodies)+ T cells, CD8 (show CD8A Antibodies)+ T cells, CD56 (show NCAM1 Antibodies)+ T cells and in serum in patients with systemic lupus erythematosus are significantly higher than those of healthy controls
The Tim-3 (show HAVCR2 Antibodies)/Gal-9 pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
The relative abundance of PIBF (show PIBF1 Antibodies), LGALS1 (show LGALS1 Antibodies), LGALS3 (show LGALS2 Antibodies), LGALS3BP (show LGALS3BP Antibodies), and LGALS9 mRNA would display a differential expression pattern in the endometrium.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.
lectin, galactoside-binding, soluble, 9
, galactoside-binding soluble lectin 9
, galectin 9
, lectin, galactoside-binding, soluble, 9 (galectin 9)
, lectin, galactose binding, soluble 5
, tumor antigen HOM-HD-21
, urate transporter/channel protein
, 36 kDa beta-galactoside-binding lectin
, Lectin galactose binding soluble 9 (Galectin-9)
, Lectin, galactose binding, soluble 9 (Galectin-9)
, urate transporter/channel
, urate transporter
, urate transporter/channel protein, isoform (UATp,i)