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Lysine (K)-Specific Demethylase 5A Proteins (KDM5A)

The protein encoded by KDM5A is a ubiquitously expressed nuclear protein. Additionally we are shipping KDM5A Antibodies (72) and KDM5A Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat KDM5A KDM5A 312678  
KDM5A 5927 P29375
Mouse KDM5A KDM5A 214899 Q3UXZ9
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Top KDM5A Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus Human DYKDDDDK Tag JARID1A / KDM5A activity assay. Recombinant JARID1A / KDM5A activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JARID1A / KDM5A activity using AlphaLISA. JARID1A / KDM5A was used in an AlphaLISA assay to determine enzyme linearity. An IC50 dose response assessment of reference compound 2,4-PDCA is also shown. This data was generated and kindly provided courtesy of ChemPartner. 20 μg Log in to see 1 to 2 Days

KDM5A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

More Proteins for Lysine (K)-Specific Demethylase 5A (KDM5A) Interaction Partners

Human Lysine (K)-Specific Demethylase 5A (KDM5A) interaction partners

  1. Treatment-induced temozolimide resistance in glioblastoma cells involves KDM5A mediated epigenetic mechanisms.

  2. Characterization of a Linked Jumonji (show JARID2 Proteins) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Proteins) Lysine 4 Demethylases.

  3. KDM5A is regulated by its reader domain through a positive-feedback mechanism

  4. Data indicate that lysine (K)-specific demethylase 5A RBP2 (JARID1A; KDM5A) epigenetically downregulated micrRNA-21 (miR (show MLXIP Proteins)-21) in blast transformation of chronic myeloid leukemia (show BCL11A Proteins) (CML (show BCR Proteins)).

  5. LSD1 (show KDM1A Proteins) is a more sensitive molecular marker than RBP2 on thyroid cancer diagnosis.

  6. MiR (show MLXIP Proteins)-212 directly regulates the expression of RBP2 and inhibits cell growth in gastric cancer, which may provide new clues to treatment.

  7. RBP2 is critical for breast cancer metastasis to the lung in multiple in vivo models. Mechanistically, RBP2 promotes metastasis as a pleiotropic positive regulator of many metastasis genes, including TNC (show TNC Proteins).

  8. RBP2 is overexpressed in HCC (show FAM126A Proteins) and negatively regulated by hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-212. The hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-212-RBP2-CDKI (show CDKN1C Proteins) pathway may be important in the pathogenesis of HCC (show FAM126A Proteins).

  9. Overexpression of RBP2 and activation of VEGF might play important roles in human gastric cancer development and progression.

  10. RBP2 is overexpressed in gastric cancer, and its inhibition triggers senescence of malignant cells at least partially by derepressing its target genes cyclin-dependent kinase (show CDK1 Proteins) inhibitors.

Mouse (Murine) Lysine (K)-Specific Demethylase 5A (KDM5A) interaction partners

  1. Kdm5a associates with p50 (show LSP1 Proteins) and binds to the Socs1 (show SOCS1 Proteins) promoter region in resting natural killer cells.

  2. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C (show EHMT2 Proteins) and the H3K4 demethylase Jarid1a/KDM5A.

  3. In terminally differentiated cells, common KDM5A and E2F4 (show E2F4 Proteins) gene targets were bound by the pRB (show PGR Proteins)-related protein p130, a DREAM complex component.

  4. Study reports that RBP2 (show RBP2 Proteins) is a demethylase that specifically catalyzes demethylation on histone H3 (show HIST3H3 Proteins) lysine 4, whose methylation is normally associated with transcriptionally active genes.

  5. JARID1a formed a complex with CLOCK-BMAL1 (show ARNTL Proteins) which was recruited to Per2 (show PER2 Proteins) promoter;it increased histone acetylation by inhibiting histone deacetylase 1 (show HDAC1 Proteins) function and enhanced transcription by CLOCK-BMAL1 (show ARNTL Proteins); JARID1a depletion shortened period of circadian rhythms

  6. KDM5A interacts physically with RBP-J (show RBPJ Proteins)

  7. mutation can downregulate cardiac cell proliferation by repressing cyclin D1 (show CCND1 Proteins) expression in the same way as jumonji (show JARID2 Proteins)

  8. A functional interplay between the PRC2 complex and the H3K4me3 demethylase Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells.

KDM5A Protein Profile

Protein Summary

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein.

Gene names and symbols associated with KDM5A

  • lysine (K)-specific demethylase 5A (Kdm5a)
  • lysine (K)-specific demethylase 5A (KDM5A)
  • retinoblastoma binding protein 2 (LOC100351408)
  • AA409370 protein
  • C76986 protein
  • JARID1A protein
  • RBBP-2 protein
  • Rbbp2 protein
  • RBP2 protein

Protein level used designations for KDM5A

jumonji, AT rich interactive domain 1A (Rbp2 like) , lysine-specific demethylase 5A , jumonji, AT rich interactive domain 1A , lysine (K)-specific demethylase 5A , JARID1A variant protein-like , jumonji AT-rich interactive domain 1A , retinoblastoma binding protein 2 , Jumonji, AT rich interactive domain 1A (RBP2-like) , histone demethylase JARID1A , jumonji/ARID domain-containing protein 1A , RBBP-2 , retinoblastoma-binding protein 2

312678 Rattus norvegicus
451737 Pan troglodytes
477727 Canis lupus familiaris
507962 Bos taurus
100056935 Equus caballus
100294704 Sus scrofa
100351408 Oryctolagus cuniculus
5927 Homo sapiens
214899 Mus musculus
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