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KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping KDM2A Antibodies (76) and many more products for this protein.
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Identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD (show PDC Proteins) domain and a newly identified Heterochromatin Protein 1 (HP1 (show DEFA1 Proteins)) interaction motif that mediates direct binding between KDM2A and HP1 (show DEFA1 Proteins). This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.
The miR (show MLXIP Proteins)-29b/KDM2A axis was involved in the RUNX3 (show RUNX3 Proteins)-mediated inhibition of gastric cancer cell proliferation and metastasis.
KDM2A-WWTR1 (show WWTR1 Proteins) fusion is associated with ossifying fibromyxoid tumors.
Silencing KDM2A, a histone demethylase (show MBD2 Proteins) and BCL6 co-repressor (show BCOR Proteins), de-repressed SFRP2 (show SFRP2 Proteins) transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 (show SFRP2 Proteins) promoter.
Findings suggest that amplification and overexpression of the KDM2A short isoform is critical in breast cancer progression.
In this study, KDM2A was identified as a novel substrate of ATM (show ATM Proteins). DSB enhanced the interaction between ATM (show ATM Proteins) and KDM2A, which induced ATM (show ATM Proteins)-mediated phosphorylation of KDM2A at T632.
The results suggest that under mild glucose starvation AMP (show APRT Proteins)-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.
FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.
The protein lysine demethylases Kdm2a and Kdm2b (show KDM2B Proteins) regulate the turnover of non-phosphorylated beta-catenin (show CTNNB1 Proteins) specifically within the nucleus via direct interaction with the fourth and fifth armadillo (show PKP1 Proteins) repeats.
Upregulation of KDM2A is very important in the progression of gastric cancer.
JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.
Kdm2a (show KDM3A Proteins) expression may be closely related to cell proliferation
Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.
we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK (show PEPCK Proteins) and G6Pase (show G6PC Proteins) expression both in vitro and in vivo
Data describe a NF-kappaB (show NFKB1 Proteins) regulatory pathway that is driven by reversible lysine methylation of p65 (show NFkBP65 Proteins), carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1) and F-box and leucine-rich repeat protein 11 (FBXL11).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
F-box and leucine-rich repeat protein 11
, CXXC-type zinc finger protein 8
, F-box/LRR-repeat protein 11
, [Histone-H3]-lysine-36 demethylase 1A
, jmjC domain-containing histone demethylation protein 1A
, jumonji C domain-containing histone demethylase 1A
, lysine-specific demethylase 2A
, lysine (K)-specific demethylase 2A
, F-box protein containing leucine repeats