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Lysine (K)-Specific Demethylase 2B Proteins (KDM2B)

KDM2B encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping Lysine (K)-Specific Demethylase 2B Antibodies (111) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM2B 84678 Q8NHM5
KDM2B 30841 Q6P1G2
Rat KDM2B KDM2B 304495  
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Top Lysine (K)-Specific Demethylase 2B Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus Human DYKDDDDK Tag FBXL10 / KDM2B activity assay. Recombinant FBXL10 / KDM2B activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant FBXL10 / KDM2B protein gel. FBXL10 / KDM2B protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days

KDM2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 2B (KDM2B) Interaction Partners

Human Lysine (K)-Specific Demethylase 2B (KDM2B) interaction partners

  1. KDM2B is an important mediator of hematopoietic cell development and has opposing roles in tumor progression that are dependent on cellular context.

  2. Jhdm1b is a positive regulator of glycolysis, glutaminolysis, and pyrimidine synthesis in HeLa cells.

  3. The protein lysine demethylases Kdm2a (show KDM2A Proteins) and Kdm2b regulate the turnover of non-phosphorylated beta-catenin (show CTNNB1 Proteins) specifically within the nucleus via direct interaction with the fourth and fifth armadillo (show PKP1 Proteins) repeats.

  4. the KDM2B/let-7b/EZH2 (show EZH2 Proteins) axis is involved in epigenetic regulation in MDS (show PAFAH1B1 Proteins), with direct effects on di- and tri (show VANGL2 Proteins)-methylation of H3K27.

  5. KDM2B specifically recognizes non-methylated DNA in CpG islands and recruits the polycomb repressive complex 1 (PRC1). This contributes to histone H2A lysine 119 ubiquitylation and gene repression.

  6. Low JHDM1B expression is associated with breast cancers.

  7. NDY1/KDM2B functions as a master regulator of polycomb (show CBX2 Proteins) complexes and controls self-renewal of breast cancer stem cells.

  8. KDM2B, an H3K36 histone demethylase implicated in bypass of cellular senescence and somatic cell reprogramming, is markedly overexpressed in PDAC, with levels increasing with disease grade and stage, and highest expression in metastases.

  9. It was found that JHDM1B mRNA is predominantly expressed in acute myeloid leukemia (show BCL11A Proteins)-derived aldehyde dehydrogenasehigh/CD34 (show CD34 Proteins)+ cells, and that aberrant expression of JHDM1B induces leukemia cell proliferation through modulation of cell cycle progression.

  10. a regulatory role of Fbxl10 in cell morphology, chemokine (show CCL1 Proteins) expression, and the metabolic control of fibroblasts.

Mouse (Murine) Lysine (K)-Specific Demethylase 2B (KDM2B) interaction partners

  1. Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation.

  2. FBXL10 protects Polycomb (show CBX2 Proteins)-occupied promoters against ectopic de novo methylation.

  3. Genetic ablation in embryonic stem cells reveal that deletion of PRC1 (show PRC1 Proteins) has genome-wide effects on PRC2 occupancy and H3K27me3; recognition of nonmethylated DNA by KDM2B, part of the PCGF1 (show PCGF1 Proteins)/PRC1 (show PRC1 Proteins) variant complex, is important for deposition of H2AK119ub1 and recruitment of PRC2 to a subset of CpG island targets and that this activity is essential for normal mouse development.

  4. Fbxl10 has a key role in regulating Ring1B (show RNF2 Proteins) recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.

  5. KDM2B silencing abrogated tumorigenicity of PDAC cell lines exhibiting loss of epithelial differentiation, whereas KDM2B overexpression cooperated with KrasG12D to promote PDAC formation in mouse models.

  6. a regulatory role of Fbxl10 in cell morphology, chemokine (show CCL1 Proteins) expression, and the metabolic control of fibroblasts.

  7. The KDM2B-let-7-EZH2 pathway contributes to the proliferation of immortal Ink4a/Arf null fibroblasts suggesting the histone-modifying enzyme functions more broadly in the regulation of cellular proliferation.

  8. Kdm2b/Jhdm1b functions as an oncogene (show RAB1A Proteins) and plays a critical role in leukemia development and maintenance.

  9. Results suggest that the Fbxl10 gene makes important contributions to embryonic neural development by regulating cell proliferation and cell death in mice.

  10. Data show that Ndy1 protects from hydrogen peroxide-induced apoptosis and G(2)/M arrest and inhibits ROS (show ROS1 Proteins)-mediated signaling and DNA damage, while knockdown of Ndy1 has the opposite effects.

Cow (Bovine) Lysine (K)-Specific Demethylase 2B (KDM2B) interaction partners

  1. genetic makeup of three inbred cattle strongly supports the causality of the KDM2B mutation

Lysine (K)-Specific Demethylase 2B (KDM2B) Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

Gene names and symbols associated with KDM2B

  • lysine (K)-specific demethylase 2Aa (kdm2aa)
  • lysine (K)-specific demethylase 2B (KDM2B)
  • F-box/LRR-repeat protein 10 (AT2G17020)
  • lysine (K)-specific demethylase 2B (Kdm2b)
  • lysine (K)-specific demethylase 2B (kdm2b)
  • lysine (K)-specific demethylase 2Ba (kdm2ba)
  • Cxxc2 protein
  • E430001G17 protein
  • F6P23.18 protein
  • F6P23_18 protein
  • fb76b11 protein
  • Fbl10 protein
  • fbxl10 protein
  • jhdm1b protein
  • KDM2B protein
  • mKIAA3014 protein
  • PCCX2 protein
  • wu:fb76b11 protein
  • wu:fd13a09 protein
  • wu:fj11c04 protein
  • zgc:85787 protein
  • zgc:158441 protein
  • zgc:158606 protein

Protein level used designations for KDM2B

JmjC domain-containing histone demethylation protein 1B , lysine (K)-specific demethylase 2B , CXXC-type zinc finger protein 2 , F-box and leucine-rich repeat protein 10 , F-box protein FBL10 , F-box/LRR-repeat protein 10 , JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein , [Histone-H3]-lysine-36 demethylase 1B , jmjC domain-containing histone demethylation protein 1B , jumonji C domain-containing histone demethylase 1B , jumonji domain-containing EMSY-interactor methyltransferase motif protein , lysine-specific demethylase 2B , protein-containing CXXC domain 2 , F-box protein containing leucine repeats 10

571851 Danio rerio
100579905 Nomascus leucogenys
816205 Arabidopsis thaliana
84678 Homo sapiens
30841 Mus musculus
486262 Canis lupus familiaris
304495 Rattus norvegicus
444267 Xenopus laevis
416844 Gallus gallus
614487 Bos taurus
406446 Danio rerio
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