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LOXL2 encodes a member of the lysyl oxidase gene family. Additionally we are shipping Lysyl Oxidase-Like 2 Antibodies (100) and Lysyl Oxidase-Like 2 Proteins (19) and many more products for this protein.
Showing 5 out of 20 products:
Human LOXL2 ELISA Kit for Sandwich ELISA - ABIN421170
Coral, Madhavan, Pukhraj, Angayarkanni: High glucose induced differential expression of lysyl oxidase and its isoform in ARPE-19 cells. in Current eye research 2013
Show all 3 references for ABIN421170
Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
ECM (show MMRN1 ELISA Kits) crosslinking by EC-derived exosomes is mediated by LOXL2.
Results show that miR (show MLXIP ELISA Kits)-26a and miR (show MLXIP ELISA Kits)-26b were significantly downregulated in renal cell carcinoma clinical specimens and appeared to function as tumor suppressors through regulation of collagen cross-linking enzymes, LOXL2 and PLOD2 (show PLOD2 ELISA Kits), both of which function as oncogenes in this disease.
Loss of tumor-suppressive miR29s enhanced cancer cell invasion in lung SCC (show CYP11A1 ELISA Kits) through direct regulation of oncogenic LOXL2.
LOXL2 promotes tumor progression.
We identified LOXL2 to be associated with the outcome of colon cancer patients. Furthermore, it can be used to stratify patients at stages II and III for further therapeutic decisions.
Data suggest that restoration of MIRN29 (microRNA 29) synthesis silences expression of LOXL2 (lysyl oxidase-like 2) and inhibits cell proliferation, migration, and invasiveness of renal cell carcinoma cells.
Lysine oxidation of the transcription factor TAF10 (show TAF10 ELISA Kits) by LOXL2 is a controlled protein modification and demonstrates a role for protein oxidation in regulating pluripotency genes.
Results show that LOXL2 is highly expressed and involved in clear cell renal cell carcinoma progression by regulating the levels of integrins a5 and b1.
identified novel alternative splicing isoform, LOXL2 Deltae13; data suggest it modulates effects of cancer cell migration and invasion through a different mechanism from full-length LOXL2 and may play an important role in tumor carcinogenesis and progression
The structure and functions of human lysyl oxidase-like 2 (LOXL2) are reviewed. [review]
LOX (show LOX ELISA Kits) and LOXL2 (show LOXL3 ELISA Kits) may play an important role in the pathogenesis of AMD (show AMD1 ELISA Kits). Targeting LOXL2 (show LOXL3 ELISA Kits) could have a broader efficacy than targeting LOX (show LOX ELISA Kits), by reducing angiogenesis and inflammation, as well as fibrosis.
Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (show LOXL3 ELISA Kits) and E47 (show TCF3 ELISA Kits) in tumor growth and their requirement for lung metastasis.
Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (show LOXL3 ELISA Kits), and further highlight the importance of generating LOXL2 (show LOXL3 ELISA Kits)-targeted therapies for the prevention of tumor progression and metastasis.
The Snail1 (show SNAI1 ELISA Kits) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (show LOXL3 ELISA Kits).
The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (show LOXL3 ELISA Kits)) is not required for LOXL2 (show LOXL3 ELISA Kits)-induced inhibition of keratinocyte differentiation.
This study provides the first evidence for the role of LOXL2 (show LOXL3 ELISA Kits) in regulating angiogenesis through collagen IV (show COL4 ELISA Kits) scaffolding.
LOXL2 (show LOXL3 ELISA Kits) promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation
The efficacy and safety of LOXL2 (show LOXL3 ELISA Kits)-specific monoclonal antibody represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases.
LoxL2 (show LOXL3 ELISA Kits) is not expressed in MC3T3-E1 cells.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
, lysyl oxidase-like 2
, Lysyl oxidase-like protein 2
, lysyl oxidase homolog 2
, lysyl oxidase homolog 2-like
, lysyl oxidase related 2
, lysyl oxidase-like protein 2
, lysyl oxidase-related protein 2
, lysyl oxidase-related protein WS9-14
, Lysyl oxidase homolog 2